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Annotation rule MF_00989
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General rule information [?]

Accession MF_00989
Dates 29-JAN-2014 (Created)
19-NOV-2019 (Last updated, Version 6)
Name AraD_entero
Scope
Bacteria; Enterobacteriaceae
Template P08203 (ARAD_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
ARAD
case <FTGroup:1>
Protein name
RecName: Full=L-ribulose-5-phosphate 4-epimerase;
EC 5.1.3.4;
AltName: Full=Phosphoribulose isomerase;
end case
case not <FTGroup:1>
Protein name
RecName: Full=Putative L-ribulose-5-phosphate 4-epimerase;
end case
Gene name
araD

Comments [?]

Function Involved in the degradation of L-arabinose. Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D-xylulose 5-phosphate (D-Xu5P) via a retroaldol/aldol mechanism (carbon-carbon bond cleavage analogous to a class II aldolase reaction).
Catalytic activity RHEA:22368: L-ribulose 5-phosphate = D-xylulose 5-phosphate
EC 5.1.3.4
Cofactor Zn(2+)
Note: Binds 1 zinc ion per subunit.
Pathway Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 3/3.
Subunit Homotetramer.
Similarity Belongs to the aldolase class II family. AraD/FucA subfamily.

Keywords [?]

Arabinose catabolism
Carbohydrate metabolism
Isomerase
Metal-binding
Zinc

Gene Ontology [?]

GO:0008742; Molecular function: L-ribulose-phosphate 4-epimerase activity.
GO:0008270; Molecular function: zinc ion binding.
GO:0019569; Biological process: L-arabinose catabolic process to xylulose 5-phosphate.

Cross-references [?]

Pfam PF00596; Aldolase_II; 1;
TIGRFAMs TIGR00760; araD; 1;

Features [?]

From: ARAD_ECOLI (P08203)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     27     28       Substrate binding     G-N  
REGION     44     45       Substrate binding     [TS]-G  
REGION     74     75       Substrate binding     S-S  
ACT_SITE     120     120       Proton donor/acceptor     D  
ACT_SITE     229     229       Proton donor/acceptor     Y  
METAL     76     76       Zinc     D   1
METAL     95     95       Zinc; via tele nitrogen     H   1
METAL     97     97       Zinc; via tele nitrogen     H   1
METAL     171     171       Zinc; via tele nitrogen     H   1

Additional information [?]

Size range 225-270 amino acids
Related rules None
Fusion None


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