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HAMAP rule MF_00989

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General rule information [?]

Accession MF_00989
Dates 29-JAN-2014 (Created)
1-JUN-2023 (Last updated, Version 10)
Name AraD_entero
Scope(s) Bacteria
Template(s) P08203 (ARAD_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00989 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ARAD
case <FTGroup:1>
Protein name RecName: Full=L-ribulose-5-phosphate 4-epimerase;
AltName: Full=Phosphoribulose isomerase;
end case
case not <FTGroup:1>
Protein name RecName: Full=Putative L-ribulose-5-phosphate 4-epimerase;
end case
Gene name Name=araD;

Comments [?]

FUNCTIONInvolved in the degradation of L-arabinose. Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D-xylulose 5- phosphate (D-Xu5P) via a retroaldol/aldol mechanism (carbon-carbon bond cleavage analogous to a class II aldolase reaction).
CATALYTIC ACTIVITY Reaction=L-ribulose 5-phosphate = D-xylulose 5-phosphate; Xref=Rhea:RHEA:22368, ChEBI:CHEBI:57737, ChEBI:CHEBI:58226; EC=;
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
PATHWAYCarbohydrate degradation; L-arabinose degradation via L- ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 3/3.
SIMILARITYBelongs to the aldolase class II family. AraD/FucA subfamily.

Keywords [?]

Gene Ontology [?]

GO:0008742; Molecular function:L-ribulose-phosphate 4-epimerase activity
GO:0008270; Molecular function:zinc ion binding
GO:0019569; Biological process:L-arabinose catabolic process to xylulose 5-phosphate

Cross-references [?]

Pfam PF00596; Aldolase_II; 1;
NCBIfam TIGR00760; araD; 1;

Features [?]

From: ARAD_ECOLI (P08203)
Key From To Description Tag Condition FTGroup
BINDING 27 28 /ligand="substrate" G-N
BINDING 44 45 /ligand="substrate" [TS]-G
BINDING 74 75 /ligand="substrate" S-S
ACT_SITE 120 120 /note="Proton donor/acceptor" D
ACT_SITE 229 229 /note="Proton donor/acceptor" Y
BINDING 76 76 /ligand="Zn(2+)"
D 1
BINDING 95 95 /ligand="Zn(2+)"
H 1
BINDING 97 97 /ligand="Zn(2+)"
H 1
BINDING 171 171 /ligand="Zn(2+)"
H 1

Additional information [?]

Size range 225-270 amino acids
Related rules None
Fusion Nter: None Cter: None

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