HAMAP rule MF_00989

General rule information [?]

Accession	MF_00989
Dates	29-JAN-2014 (Created) 19-NOV-2022 (Last updated, Version 9)

Name	AraD_entero

Scope

Bacteria; Enterobacteriaceae

Template

P08203 (ARAD_ECOLI)

Triggered by

HAMAP; MF_00989 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

ARAD

case <FTGroup:1>

Protein name

RecName:		Full=L-ribulose-5-phosphate 4-epimerase;
		EC 5.1.3.4;
AltName:		Full=Phosphoribulose isomerase;

end case

case not <FTGroup:1>

Protein name

RecName:

Full=Putative L-ribulose-5-phosphate 4-epimerase;

end case

Gene name

araD

Comments [?]

Function	Involved in the degradation of L-arabinose. Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D-xylulose 5-phosphate (D-Xu5P) via a retroaldol/aldol mechanism (carbon-carbon bond cleavage analogous to a class II aldolase reaction).
Catalytic activity	RHEA:22368: L-ribulose 5-phosphate = D-xylulose 5-phosphate EC 5.1.3.4
Cofactor	Zn(2+) Note: Binds 1 zinc ion per subunit.
Pathway	Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 3/3.
Subunit	Homotetramer.
Similarity	Belongs to the aldolase class II family. AraD/FucA subfamily.

Keywords [?]

Arabinose catabolism
Carbohydrate metabolism
Isomerase
Metal-binding
Zinc

Gene Ontology [?]

GO:0008742; Molecular function: L-ribulose-phosphate 4-epimerase activity.
GO:0008270; Molecular function: zinc ion binding.
GO:0019569; Biological process: L-arabinose catabolic process to xylulose 5-phosphate.

Cross-references [?]

Pfam	PF00596; Aldolase_II; 1;
TIGRFAMs	TIGR00760; araD; 1;

Features [?]

From: ARAD_ECOLI (P08203)

Key From To Description Tag Condition FTGroup

BINDING 27 28 /ligand="substrate G-N

BINDING 44 45 /ligand="substrate [TS]-G

BINDING 74 75 /ligand="substrate S-S

ACT_SITE 120 120 Proton donor/acceptor D

ACT_SITE 229 229 Proton donor/acceptor Y

BINDING 76 76 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 D 1

BINDING 95 95 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 H 1

BINDING 97 97 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 H 1

BINDING 171 171 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 H 1

Additional information [?]

Size range	225-270 amino acids
Related rules	None
Fusion	None

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