HAMAP rule MF_00989
General rule information
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Accession | MF_00989 |
Dates | 29-JAN-2014 (Created) 1-JUN-2023 (Last updated, Version 10) |
Name | AraD_entero |
Scope | Bacteria; Enterobacteriaceae |
Template | P08203 (ARAD_ECOLI) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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case <FTGroup:1>
Protein name |
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end case
case not <FTGroup:1>
Protein name |
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end case
Gene name |
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Comments
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Function | Involved in the degradation of L-arabinose. Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D-xylulose 5-phosphate (D-Xu5P) via a retroaldol/aldol mechanism (carbon-carbon bond cleavage analogous to a class II aldolase reaction). |
Catalytic activity | RHEA:22368: L-ribulose 5-phosphate = D-xylulose 5-phosphate
EC 5.1.3.4 |
Cofactor | Zn(2+) Note: Binds 1 zinc ion per subunit. |
Pathway | Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 3/3. |
Subunit | Homotetramer. |
Similarity | Belongs to the aldolase class II family. AraD/FucA subfamily. |
Keywords
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Gene Ontology
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GO:0008742; Molecular function: L-ribulose-phosphate 4-epimerase activity.
GO:0008270; Molecular function: zinc ion binding.
GO:0019569; Biological process: L-arabinose catabolic process to xylulose 5-phosphate.
GO:0008270; Molecular function: zinc ion binding.
GO:0019569; Biological process: L-arabinose catabolic process to xylulose 5-phosphate.
Cross-references
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Features
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From: ARAD_ECOLI (P08203) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 27 | 28 | /ligand="substrate | G-N | ||||||||
BINDING | 44 | 45 | /ligand="substrate | [TS]-G | ||||||||
BINDING | 74 | 75 | /ligand="substrate | S-S | ||||||||
ACT_SITE | 120 | 120 | Proton donor/acceptor | D | ||||||||
ACT_SITE | 229 | 229 | Proton donor/acceptor | Y | ||||||||
BINDING | 76 | 76 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | D | 1 | |||||||
BINDING | 95 | 95 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | H | 1 | |||||||
BINDING | 97 | 97 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | H | 1 | |||||||
BINDING | 171 | 171 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | H | 1 |
Additional information
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Size range | 225-270 amino acids |
Related rules | None |
Fusion | None |