HAMAP rule MF_00993
General rule information
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Accession | MF_00993 |
Dates | 14-FEB-2014 (Created) 19-NOV-2022 (Last updated, Version 12) |
Name | MqnE |
Scope | Bacteria |
Template | Q5SK48 (MQNE_THET8) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. |
Catalytic activity | RHEA:33075: 3-[(1-carboxyvinyl)-oxy]benzoate + H2O + S-adenosyl-L-methionine = 6-amino-6-deoxyfutalosine + H(+) + hydrogencarbonate + L-methionine
EC 2.5.1.120 |
case <FTGroup:1>
Cofactor | [4Fe-4S] cluster Note: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. |
end case
Pathway | Quinol/quinone metabolism; menaquinone biosynthesis. |
Similarity | Belongs to the radical SAM superfamily. MqnE family. |
Keywords
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case <FTGroup:1>
end case
Gene Ontology
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case <FTGroup:1>
GO:0005506; Molecular function: iron ion binding.
end case
GO:0016765; Molecular function: transferase activity, transferring alkyl or aryl (other than methyl) groups.
GO:0009234; Biological process: menaquinone biosynthetic process.
GO:0009234; Biological process: menaquinone biosynthetic process.
Cross-references
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Pfam | PF04055; Radical_SAM; 1; |
TIGRFAMs | TIGR03700; mena_SCO4494; 1; |
TIGR00423; TIGR00423; 1; | |
PIRSF | PIRSF004762; CHP00423; 1; |
PROSITE | PS51918; RADICAL_SAM; 1; trigger=PRU01266; |
Features
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From: MQNE_THET8 (Q5SK48) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 69 | 69 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="4Fe-4S-S-AdoMet | C | 1 | |||||||
BINDING | 73 | 73 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="4Fe-4S-S-AdoMet | C | 1 | |||||||
BINDING | 76 | 76 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="4Fe-4S-S-AdoMet | C | 1 |
Additional information
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Size range | 335-420 amino acids |
Related rules | None |
Fusion | None |