HAMAP rule MF_00996

General rule information [?]

Accession	MF_00996
Dates	17-FEB-2014 (Created) 2-MAY-2024 (Last updated, Version 7)
Name	MqnD
Scope(s)	Bacteria Archaea
Template(s)	Q5SI12 (MQND_THET8); Q9KXN1 (MQND_STRCO); [ Recover all ]
Triggered by	HAMAP; MF_00996 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	MQND
Protein name	RecName: Full=1,4-dihydroxy-6-naphtoate synthase; EC=4.1.99.29; AltName: Full=Menaquinone biosynthetic enzyme MqnD;
Gene name	Name=mqnD;

Comments [?]

FUNCTION	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).
CATALYTIC ACTIVITY	Reaction=cyclic dehypoxanthinylfutalosinate = 1,4-dihydroxy-6- naphthoate + dihydroxyacetone; Xref=Rhea:RHEA:33087, ChEBI:CHEBI:16016, ChEBI:CHEBI:64254, ChEBI:CHEBI:64270; EC=4.1.99.29;
PATHWAY	Quinol/quinone metabolism; menaquinone biosynthesis.
SIMILARITY	Belongs to the MqnA/MqnD family. MqnD subfamily.

Keywords [?]

Gene Ontology [?]

GO:0016830; Molecular function:carbon-carbon lyase activity

GO:0009234; Biological process:menaquinone biosynthetic process

Cross-references [?]

Pfam	PF02621; VitK2_biosynth; 1;

Features [?]

From: MQND_THET8 (Q5SI12)

Key

From

Description

Tag

Condition

FTGroup

BINDING

/ligand="substrate"

K-[LIV]-S

BINDING

107

108

/ligand="substrate"

[TS]-A

ACT_SITE

145

/note="Proton acceptor"

Additional information [?]