HAMAP rule MF_00997
General rule information
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| Accession | MF_00997 |
| Dates | 3-MAR-2014 (Created)
19-NOV-2022 (Last updated, Version 7) |
| Name | Protease_BepA |
| Scope(s) |
Bacteria Gammaproteobacteria |
| Template(s) | P66948 (BEPA_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00997 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | BEPA |
| case <OC:Enterobacterales> | |
| Protein name | RecName: Full=Beta-barrel assembly-enhancing protease; EC=3.4.-.-; |
| Gene name | Name=bepA; |
| else | |
| Protein name | RecName: Full=Putative beta-barrel assembly-enhancing protease; EC=3.4.-.-; |
| end case | |
Comments
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| FUNCTION | Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state. |
| case <FTGroup:1> | |
| COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.; |
| end case | |
| SUBCELLULAR LOCATION | Periplasm. |
| SIMILARITY | Belongs to the peptidase M48 family. BepA subfamily. |
Keywords
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| Hydrolase | |
| Metalloprotease | |
| Periplasm | |
| Protease | |
| Signal | |
| case <FTGroup:1> | |
| Metal-binding | |
| Zinc | |
| end case | |
Gene Ontology
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| GO:0008233; Molecular function:peptidase activity | |
| case <FTGroup:1> | |
| GO:0008270; Molecular function:zinc ion binding | |
| end case | |
| GO:0042597; Cellular component:periplasmic space | |
Cross-references
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| PROSITE | PS50005; TPR; 1; |
| PROSITE | PS50293; TPR_REGION; 1; |
| Pfam | PF01435; Peptidase_M48; 1; |
| Pfam | PF07720; TPR_3; 1; |
| Pfam | PF07719; TPR_2; 1; |
| General | Signal; -; 1; |
| REP | Repeat_TPR; TPR; 0-6; |
Features
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| From: BEPA_ECOLI (P66948) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 137 | 137 | E | |||||||||
| ACT_SITE | 205 | 205 | /note="Proton donor" | D | ||||||||
| BINDING | 136 | 136 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
H | 1 | |||||||
| BINDING | 140 | 140 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
H | 1 | |||||||
| BINDING | 201 | 201 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
E | 1 | |||||||
Additional information
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| Size range | 435-600 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |