HAMAP rule MF_00997

General rule information [?]

Accession	MF_00997
Dates	3-MAR-2014 (Created) 19-NOV-2022 (Last updated, Version 7)

Name	Protease_BepA

Scope

Bacteria; Gammaproteobacteria

Template

P66948 (BEPA_ECOLI)

Triggered by

HAMAP; MF_00997 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

BEPA

case <OC:Enterobacterales>

Protein name

RecName:		Full=Beta-barrel assembly-enhancing protease;
		EC 3.4.-.-;

Gene name

bepA

else

Protein name

RecName:		Full=Putative beta-barrel assembly-enhancing protease;
		EC 3.4.-.-;

end case

Comments [?]

Function

Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state.

case <FTGroup:1>

Cofactor

Zn(2+)
Note: Binds 1 zinc ion per subunit.

end case

Subcellular location	Periplasm.
Similarity	Belongs to the peptidase M48 family. BepA subfamily.

Keywords [?]

Hydrolase
Metalloprotease
Periplasm
Protease
Signal

case <FTGroup:1>

Metal-binding
Zinc

end case

Gene Ontology [?]

GO:0008233; Molecular function: peptidase activity.

case <FTGroup:1>

GO:0008270; Molecular function: zinc ion binding.

end case

GO:0042597; Cellular component: periplasmic space.

Cross-references [?]

PROSITE	PS50005; TPR; 1;
	PS50293; TPR_REGION; 1;
Pfam	PF01435; Peptidase_M48; 1;
	PF07720; TPR_3; 1;
	PF07719; TPR_2; 1;

Computed features [?]

General	Signal; -; 1; trigger=yes;
REP	Repeat_TPR; TPR; 0-6; trigger=yes;

Features [?]

From: BEPA_ECOLI (P66948)

Key From To Description Tag Condition FTGroup

ACT_SITE 137 137 E

ACT_SITE 205 205 Proton donor D

BINDING 136 136 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic H 1

BINDING 140 140 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic H 1

BINDING 201 201 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic E 1

Additional information [?]

Size range	435-600 amino acids
Related rules	None
Fusion	None

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