HAMAP rule MF_00997
General rule information
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Accession | MF_00997 |
Dates | 3-MAR-2014 (Created) 19-NOV-2022 (Last updated, Version 7) |
Name | Protease_BepA |
Scope | Bacteria; Gammaproteobacteria |
Template | P66948 (BEPA_ECOLI) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
|
case <OC:Enterobacterales>
Protein name |
|
Gene name |
|
else
Protein name |
|
end case
Comments
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Function | Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state. |
case <FTGroup:1>
Cofactor | Zn(2+) Note: Binds 1 zinc ion per subunit. |
end case
Subcellular location | Periplasm. |
Similarity | Belongs to the peptidase M48 family. BepA subfamily. |
Keywords
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case <FTGroup:1>
end case
Gene Ontology
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GO:0008233; Molecular function: peptidase activity.
case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case
GO:0042597; Cellular component: periplasmic space.
Cross-references
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PROSITE | PS50005; TPR; 1; |
PS50293; TPR_REGION; 1; | |
Pfam | PF01435; Peptidase_M48; 1; |
PF07720; TPR_3; 1; | |
PF07719; TPR_2; 1; |
Computed features
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General | Signal; -; 1; trigger=yes; |
REP | Repeat_TPR; TPR; 0-6; trigger=yes; |
Features
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From: BEPA_ECOLI (P66948) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 137 | 137 | E | |||||||||
ACT_SITE | 205 | 205 | Proton donor | D | ||||||||
BINDING | 136 | 136 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic | H | 1 | |||||||
BINDING | 140 | 140 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic | H | 1 | |||||||
BINDING | 201 | 201 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic | E | 1 |
Additional information
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Size range | 435-600 amino acids |
Related rules | None |
Fusion | None |