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Annotation rule MF_00997
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General rule information [?]

Accession MF_00997
Dates 3-MAR-2014 (Created)
19-NOV-2019 (Last updated, Version 5)
Name Protease_BepA
Scope
Bacteria; Gammaproteobacteria
Template P66948 (BEPA_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
BEPA
case <OC:Enterobacterales>
Protein name
RecName: Full=Beta-barrel assembly-enhancing protease;
EC 3.4.-.-;
Gene name
bepA
else
Protein name
RecName: Full=Putative beta-barrel assembly-enhancing protease;
EC 3.4.-.-;
end case

Comments [?]

Function Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state.
case <FTGroup:1>
Cofactor Zn(2+)
Note: Binds 1 zinc ion per subunit.
end case
Subcellular location Periplasm.
Similarity Belongs to the peptidase M48 family. BepA subfamily.

Keywords [?]

Hydrolase
Metalloprotease
Periplasm
Protease
Signal
case <FTGroup:1>
Metal-binding
Zinc
end case

Gene Ontology [?]

GO:0008233; Molecular function: peptidase activity.
case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case
GO:0042597; Cellular component: periplasmic space.

Cross-references [?]

PROSITE PS50005; TPR; 1;
PS50293; TPR_REGION; 1;
Pfam PF01435; Peptidase_M48; 1;
PF07720; TPR_3; 1;
PF07719; TPR_2; 1;

Computed features [?]

General Signal; -; 1; trigger=yes;
REP Repeat_TPR; TPR; 0-6; trigger=yes;

Features [?]

From: BEPA_ECOLI (P66948)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     137     137             E  
ACT_SITE     205     205       Proton donor     D  
METAL     136     136       Zinc; catalytic     H   1
METAL     140     140       Zinc; catalytic     H   1
METAL     201     201       Zinc; catalytic     E   1

Additional information [?]

Size range 435-600 amino acids
Related rules None
Fusion None


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