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HAMAP rule MF_00997

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General rule information [?]

Accession MF_00997
Dates 3-MAR-2014 (Created)
19-NOV-2022 (Last updated, Version 7)
Name Protease_BepA
Scope(s) Bacteria
Template(s) P66948 (BEPA_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00997 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier BEPA
case <OC:Enterobacterales>
Protein name RecName: Full=Beta-barrel assembly-enhancing protease;
Gene name Name=bepA;
Protein name RecName: Full=Putative beta-barrel assembly-enhancing protease;
end case

Comments [?]

FUNCTIONFunctions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state.
case <FTGroup:1>
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
end case
SIMILARITYBelongs to the peptidase M48 family. BepA subfamily.

Keywords [?]

Gene Ontology [?]

GO:0008233; Molecular function:peptidase activity
case <FTGroup:1>
GO:0008270; Molecular function:zinc ion binding
end case
GO:0042597; Cellular component:periplasmic space

Cross-references [?]

PROSITE PS50005; TPR; 1;
Pfam PF01435; Peptidase_M48; 1;
Pfam PF07720; TPR_3; 1;
Pfam PF07719; TPR_2; 1;
General Signal; -; 1;
REP Repeat_TPR; TPR; 0-6;

Features [?]

From: BEPA_ECOLI (P66948)
Key From To Description Tag Condition FTGroup
ACT_SITE 137 137 E
ACT_SITE 205 205 /note="Proton donor" D
BINDING 136 136 /ligand="Zn(2+)"
H 1
BINDING 140 140 /ligand="Zn(2+)"
H 1
BINDING 201 201 /ligand="Zn(2+)"
E 1

Additional information [?]

Size range 435-600 amino acids
Related rules None
Fusion Nter: None Cter: None

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