HAMAP rule MF_01022
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_01022 |
| Accession | MF_01022 |
| Dates | 28-FEB-2005 (Created)
03-SEP-2024 (Last updated, Version 25) |
| Name | Bifunc_HisB |
| Scope(s) |
Bacteria |
| Template(s) | Q9S5G5; P06987; [ Recover all ] |
| Triggered by |
HAMAP; MF_01022 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | HIS7 |
| Protein name | RecName: Full=Histidine biosynthesis bifunctional protein HisB; Includes: RecName: Full=Histidinol-phosphatase; EC=3.1.3.15; Includes: RecName: Full=Imidazoleglycerol-phosphate dehydratase; Short=IGPD; EC=4.2.1.19; |
| Gene name | Name=hisB; |
Comments
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| CATALYTIC ACTIVITY | Reaction=D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol- 4-yl)-2-oxopropyl phosphate + H2O; Xref=Rhea:RHEA:11040, ChEBI:CHEBI:15377, ChEBI:CHEBI:57766, ChEBI:CHEBI:58278; EC=4.2.1.19; |
| CATALYTIC ACTIVITY | Reaction=L-histidinol phosphate + H2O = L-histidinol + phosphate; Xref=Rhea:RHEA:14465, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57699, ChEBI:CHEBI:57980; EC=3.1.3.15; |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| case <FTGroup:1> | |
| COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; |
| end case | |
| PATHWAY | Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9. |
| PATHWAY | Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | In the N-terminal section; belongs to the histidinol- phosphatase family. |
| SIMILARITY | In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. |
Keywords
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| Amino-acid biosynthesis | |
| Cytoplasm | |
| Histidine biosynthesis | |
| Hydrolase | |
| Lyase | |
| Magnesium | |
| Metal-binding | |
| Multifunctional enzyme | |
| case <FTGroup:1> | |
| Zinc | |
| end case | |
Gene Ontology
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| GO:0004401; Molecular function:histidinol-phosphatase activity |
| GO:0004424; Molecular function:imidazoleglycerol-phosphate dehydratase activity |
| GO:0000105; Biological process:L-histidine biosynthetic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF00475; IGPD; 1; |
| Pfam | PF08645; PNK3P; 1; |
| NCBIfam | TIGR01662; HAD-SF-IIIA; 1; |
| NCBIfam | TIGR01261; HisB_Nterm; 1; |
| NCBIfam | TIGR01656; Histidinol-ppas; 1; |
| PROSITE | PS00954; IGP_DEHYDRATASE_1; 1; |
| PROSITE | PS00955; IGP_DEHYDRATASE_2; 1; |
Features
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| From: HIS7_ECO57 (Q9S5G5) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REGION | Nter | 166 | /note="Histidinol-phosphatase" | |||||||||
| REGION | 167 | Cter | /note="Imidazoleglycerol-phosphate dehydratase" | |||||||||
| ACT_SITE | 9 | 9 | /note="Nucleophile" | D | ||||||||
| ACT_SITE | 11 | 11 | /note="Proton donor" | D | ||||||||
| BINDING | 9 | 9 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | ||||||||
| BINDING | 11 | 11 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | ||||||||
| BINDING | 93 | 93 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 95 | 95 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H | 1 | |||||||
| BINDING | 101 | 101 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 103 | 103 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 130 | 130 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | ||||||||
Additional information
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| Size range | 350-390 amino acids |
| Related rules |
MF_00076 |
| Fusion | Nter: None Cter: None |