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Annotation rule MF_01022
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General rule information [?]

Accession MF_01022
Dates 14-JUN-2002 (Created)
19-NOV-2019 (Last updated, Version 29)
Name Bifunc_HisB
Scope
Bacteria
Templates Q9S5G5 (HIS7_ECO57); P06987 (HIS7_ECOLI): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
HIS7
Protein name
RecName: Full=Histidine biosynthesis bifunctional protein HisB;
Includes:
RecName: Full=Histidinol-phosphatase;
EC 3.1.3.15;
Includes:
RecName: Full=Imidazoleglycerol-phosphate dehydratase;
Short=IGPD;
EC 4.2.1.19;
Gene name
hisB

Comments [?]

Catalytic activity RHEA:11040: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O
EC 4.2.1.19
RHEA:14465: H2O + L-histidinol phosphate = L-histidinol + phosphate
EC 3.1.3.15
Cofactor Mg(2+)
case <FTGroup:1>
Cofactor Zn(2+)
end case
Pathway Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.
Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.
Subcellular location Cytoplasm.
Similarity In the N-terminal section; belongs to the histidinol-phosphatase family.
In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.

Keywords [?]

Amino-acid biosynthesis
Cytoplasm
Histidine biosynthesis
Hydrolase
Lyase
Magnesium
Metal-binding
Multifunctional enzyme
case <FTGroup:1>
Zinc
end case

Gene Ontology [?]

GO:0004401; Molecular function: histidinol-phosphatase activity.
GO:0004424; Molecular function: imidazoleglycerol-phosphate dehydratase activity.
GO:0000105; Biological process: histidine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00475; IGPD; 1;
PF08645; PNK3P; 1;
TIGRFAMs TIGR01662; HAD-SF-IIIA; 1;
TIGR01261; HisB_Nterm; 1;
TIGR01656; Histidinol-ppas; 1;
PROSITE PS00954; IGP_DEHYDRATASE_1; 1;
PS00955; IGP_DEHYDRATASE_2; 1;

Features [?]

From: HIS7_ECO57 (Q9S5G5)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     Nter     166       Histidinol-phosphatase        
REGION     167     Cter       Imidazoleglycerol-phosphate dehydratase        
ACT_SITE     9     9       Nucleophile     D  
ACT_SITE     11     11       Proton donor     D  
METAL     9     9       Magnesium     D  
METAL     11     11       Magnesium; via carbonyl oxygen     D  
METAL (Optional)     93     93       Zinc     C   1
METAL (Optional)     95     95       Zinc; via pros nitrogen     H   1
METAL (Optional)     101     101       Zinc     C   1
METAL (Optional)     103     103       Zinc     C   1
METAL     130     130       Magnesium     D  

Additional information [?]

Size range 350-390 amino acids
Related rules MF_00076 (HIS7)
Fusion None


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