HAMAP rule MF_01022

General rule information [?]

Accession	MF_01022
Dates	14-JUN-2002 (Created) 1-JUN-2023 (Last updated, Version 32)

Name	Bifunc_HisB

Scope

Bacteria

Templates

Q9S5G5 (HIS7_ECO57); P06987 (HIS7_ECOLI): [Recover all]

Triggered by

HAMAP; MF_01022 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

HIS7

Protein name

RecName:		Full=Histidine biosynthesis bifunctional protein HisB;
Includes:
	RecName:		Full=Histidinol-phosphatase;
			EC 3.1.3.15;
Includes:
	RecName:		Full=Imidazoleglycerol-phosphate dehydratase;
			Short=IGPD;
			EC 4.2.1.19;

Gene name

hisB

Comments [?]

Catalytic activity	RHEA:11040: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O EC 4.2.1.19
	RHEA:14465: H2O + L-histidinol phosphate = L-histidinol + phosphate EC 3.1.3.15
Cofactor	Mg(2+)

case <FTGroup:1>

Cofactor

Zn(2+)

end case

Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.
	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.
Subcellular location	Cytoplasm.
Similarity	In the N-terminal section; belongs to the histidinol-phosphatase family.
	In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.

Keywords [?]

Amino-acid biosynthesis
Cytoplasm
Histidine biosynthesis
Hydrolase
Lyase
Magnesium
Metal-binding
Multifunctional enzyme

case <FTGroup:1>

Zinc

end case

Gene Ontology [?]

GO:0004401; Molecular function: histidinol-phosphatase activity.
GO:0004424; Molecular function: imidazoleglycerol-phosphate dehydratase activity.
GO:0000105; Biological process: histidine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF00475; IGPD; 1;
	PF08645; PNK3P; 1;
NCBIfam	TIGR01662; HAD-SF-IIIA; 1;
	TIGR01261; HisB_Nterm; 1;
	TIGR01656; Histidinol-ppas; 1;
PROSITE	PS00954; IGP_DEHYDRATASE_1; 1;
	PS00955; IGP_DEHYDRATASE_2; 1;

Features [?]

From: HIS7_ECO57 (Q9S5G5)

Key From To Description Tag Condition FTGroup

REGION Nter 166 Histidinol-phosphatase

REGION 167 Cter Imidazoleglycerol-phosphate dehydratase

ACT_SITE 9 9 Nucleophile D

ACT_SITE 11 11 Proton donor D

BINDING 9 9 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 D

BINDING 11 11 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 D

BINDING (Optional) 93 93 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 C 1

BINDING (Optional) 95 95 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 H 1

BINDING (Optional) 101 101 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 C 1

BINDING (Optional) 103 103 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 C 1

BINDING 130 130 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 D

Additional information [?]

Size range	350-390 amino acids
Related rules	MF_00076 (HIS7)
Fusion	None

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