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HAMAP rule MF_01022

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General rule information [?]

Accession MF_01022
Dates 14-JUN-2002 (Created)
1-JUN-2023 (Last updated, Version 32)
Name Bifunc_HisB
Scope(s) Bacteria
Template(s) Q9S5G5 (HIS7_ECO57); P06987 (HIS7_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01022 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier HIS7
Protein name RecName: Full=Histidine biosynthesis bifunctional protein HisB;
RecName: Full=Histidinol-phosphatase;
RecName: Full=Imidazoleglycerol-phosphate dehydratase;
Gene name Name=hisB;

Comments [?]

CATALYTIC ACTIVITY Reaction=D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol- 4-yl)-2-oxopropyl phosphate + H2O; Xref=Rhea:RHEA:11040, ChEBI:CHEBI:15377, ChEBI:CHEBI:57766, ChEBI:CHEBI:58278; EC=;
CATALYTIC ACTIVITY Reaction=H2O + L-histidinol phosphate = L-histidinol + phosphate; Xref=Rhea:RHEA:14465, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57699, ChEBI:CHEBI:57980; EC=;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
case <FTGroup:1>
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
end case
PATHWAYAmino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.
PATHWAYAmino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.
SIMILARITYIn the N-terminal section; belongs to the histidinol- phosphatase family.
SIMILARITYIn the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.

Keywords [?]

Gene Ontology [?]

GO:0004401; Molecular function:histidinol-phosphatase activity
GO:0004424; Molecular function:imidazoleglycerol-phosphate dehydratase activity
GO:0000105; Biological process:histidine biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00475; IGPD; 1;
Pfam PF08645; PNK3P; 1;
NCBIfam TIGR01662; HAD-SF-IIIA; 1;
NCBIfam TIGR01261; HisB_Nterm; 1;
NCBIfam TIGR01656; Histidinol-ppas; 1;

Features [?]

From: HIS7_ECO57 (Q9S5G5)
Key From To Description Tag Condition FTGroup
REGION Nter 166 /note="Histidinol-phosphatase"
REGION 167 Cter /note="Imidazoleglycerol-phosphate dehydratase"
ACT_SITE 9 9 /note="Nucleophile" D
ACT_SITE 11 11 /note="Proton donor" D
BINDING 9 9 /ligand="Mg(2+)"
BINDING 11 11 /ligand="Mg(2+)"
BINDING 93 93 /ligand="Zn(2+)"
C 1
BINDING 95 95 /ligand="Zn(2+)"
H 1
BINDING 101 101 /ligand="Zn(2+)"
C 1
BINDING 103 103 /ligand="Zn(2+)"
C 1
BINDING 130 130 /ligand="Mg(2+)"

Additional information [?]

Size range 350-390 amino acids
Related rules MF_00076
Fusion Nter: None Cter: None

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