HAMAP rule MF_01022
General rule information
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Accession | MF_01022 |
Dates | 14-JUN-2002 (Created) 1-JUN-2023 (Last updated, Version 32) |
Name | Bifunc_HisB |
Scope | Bacteria |
Templates | Q9S5G5 (HIS7_ECO57); P06987 (HIS7_ECOLI): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Catalytic activity | RHEA:11040: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O
EC 4.2.1.19 |
RHEA:14465: H2O + L-histidinol phosphate = L-histidinol + phosphate
EC 3.1.3.15 |
|
Cofactor | Mg(2+) |
case <FTGroup:1>
Cofactor | Zn(2+) |
end case
Pathway | Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9. |
Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9. | |
Subcellular location | Cytoplasm. |
Similarity | In the N-terminal section; belongs to the histidinol-phosphatase family. |
In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. |
Keywords
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Amino-acid biosynthesis
Cytoplasm
Histidine biosynthesis
Hydrolase
Lyase
Magnesium
Metal-binding
Multifunctional enzyme
Cytoplasm
Histidine biosynthesis
Hydrolase
Lyase
Magnesium
Metal-binding
Multifunctional enzyme
case <FTGroup:1>
end case
Gene Ontology
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GO:0004401; Molecular function: histidinol-phosphatase activity.
GO:0004424; Molecular function: imidazoleglycerol-phosphate dehydratase activity.
GO:0000105; Biological process: histidine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
GO:0004424; Molecular function: imidazoleglycerol-phosphate dehydratase activity.
GO:0000105; Biological process: histidine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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Pfam | PF00475; IGPD; 1; |
PF08645; PNK3P; 1; | |
NCBIfam | TIGR01662; HAD-SF-IIIA; 1; |
TIGR01261; HisB_Nterm; 1; | |
TIGR01656; Histidinol-ppas; 1; | |
PROSITE | PS00954; IGP_DEHYDRATASE_1; 1; |
PS00955; IGP_DEHYDRATASE_2; 1; |
Features
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From: HIS7_ECO57 (Q9S5G5) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
REGION | Nter | 166 | Histidinol-phosphatase | |||||||||
REGION | 167 | Cter | Imidazoleglycerol-phosphate dehydratase | |||||||||
ACT_SITE | 9 | 9 | Nucleophile | D | ||||||||
ACT_SITE | 11 | 11 | Proton donor | D | ||||||||
BINDING | 9 | 9 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | D | ||||||||
BINDING | 11 | 11 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | D | ||||||||
BINDING (Optional) | 93 | 93 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | C | 1 | |||||||
BINDING (Optional) | 95 | 95 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | H | 1 | |||||||
BINDING (Optional) | 101 | 101 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | C | 1 | |||||||
BINDING (Optional) | 103 | 103 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | C | 1 | |||||||
BINDING | 130 | 130 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | D |
Additional information
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Size range | 350-390 amino acids |
Related rules | MF_00076 (HIS7) |
Fusion | None |