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Annotation rule MF_01038
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General rule information [?]

Accession MF_01038
Dates 19-DEC-2002 (Created)
19-NOV-2019 (Last updated, Version 38)
Name GpmI
Scope
Bacteria
Archaea
Plastid
Templates Q9X519 (GPMI_GEOSE); P39773 (GPMI_BACSU); P37689 (GPMI_ECOLI): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GPMI
Protein name
RecName: Full=2,3-bisphosphoglycerate-independent phosphoglycerate mutase;
Short=BPG-independent PGAM;
Short=Phosphoglyceromutase;
Short=iPGM;
EC 5.4.2.12;
Gene name
gpmI

Comments [?]

case <OC:Bacillaceae>
Function Essential for rapid growth and for sporulation. Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
else
Function Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
end case
Catalytic activity RHEA:15901: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate
EC 5.4.2.12
case <FTGroup:1>
Cofactor Mn(2+)
Note: Binds 2 manganese ions per subunit.
end case
Pathway Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.
case <OC:Bacteria>
Subunit Monomer.
end case
case <OG:Chloroplast>
Subcellular location Plastid, chloroplast.
end case
Similarity Belongs to the BPG-independent phosphoglycerate mutase family.

Keywords [?]

Isomerase
Glycolysis
case <FTGroup:1>
Metal-binding
Manganese
end case
case <OC:Bacillaceae> and <FT:15>
Phosphoprotein
end case
case <OC:Bacillaceae>
Sporulation
end case

Gene Ontology [?]

GO:0046537; Molecular function: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity.
case <FTGroup:1>
GO:0030145; Molecular function: manganese ion binding.
end case
GO:0006096; Biological process: glycolytic process.
case <OG:Chloroplast>
GO:0009507; Cellular component: chloroplast.
end case

Cross-references [?]

Pfam PF06415; iPGM_N; 1;
PF01676; Metalloenzyme; 1;
TIGRFAMs TIGR01307; Pgm_bpd_ind; 1;

Features [?]

From: GPMI_GEOSE (Q9X519)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     153     154       Substrate binding     R-D  
REGION     261     264       Substrate binding     R-x-x-R  
ACT_SITE     62     62       Phosphoserine intermediate     S  
METAL     12     12       Manganese 2     D   1
METAL     62     62       Manganese 2     S   1
METAL     403     403       Manganese 1     D   1
METAL     407     407       Manganese 1     H   1
METAL     444     444       Manganese 2     D   1
METAL     445     445       Manganese 2     H   1
METAL     462     462       Manganese 1     H   1
BINDING     123     123       Substrate     H  
BINDING     185     185       Substrate     R  
BINDING     191     191       Substrate     [RK]  
BINDING     336     336       Substrate     K  
case <OC:Bacillaceae>
From: GPMI_BACSU (P39773)
MOD_RES     36     36       Phosphotyrosine     Y  
end case

Additional information [?]

Size range 490-552 amino acids
Related rules MF_01402 (APGM)
Fusion None
Comments Possible wrong start in METMA and in the second copy of gpmI in METAC. LEPIC and LEPIN seem to be more closely related to protozoan and plant gpmI than to bacterial orthologs; not shown in alignment.


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