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HAMAP rule MF_01038

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General rule information [?]

PURL https://purl.expasy.org/hamap/rule/MF_01038
Accession MF_01038
Dates 19-DEC-2002 (Created)
14-JAN-2025 (Last updated, Version 43)
Name GpmI
Scope(s) Bacteria
Archaea
Plastid
Template(s) Q9X519 (GPMI_GEOSE); P39773 (GPMI_BACSU); P37689 (GPMI_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01038 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier GPMI
Protein name RecName: Full=2,3-bisphosphoglycerate-independent phosphoglycerate mutase;
                 Short=BPG-independent PGAM;
                 Short=Phosphoglyceromutase;
                 Short=iPGM;
                 EC=5.4.2.12;
Gene name Name=gpmI;

Comments [?]

case <OC:Bacillaceae>
FUNCTIONEssential for rapid growth and for sporulation. Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
else
FUNCTIONCatalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate.
end case
CATALYTIC ACTIVITY Reaction=(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate; Xref=Rhea:RHEA:15901, ChEBI:CHEBI:58272, ChEBI:CHEBI:58289; EC=5.4.2.12;
case <FTGroup:1>
COFACTOR Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 manganese ions per subunit.;
end case
PATHWAYCarbohydrate degradation; glycolysis; pyruvate from D- glyceraldehyde 3-phosphate: step 3/5.
case <OC:Bacteria>
SUBUNITMonomer.
end case
case <OG:Chloroplast>
SUBCELLULAR LOCATIONPlastid, chloroplast.
end case
SIMILARITYBelongs to the BPG-independent phosphoglycerate mutase family.

Keywords [?]

Isomerase
Glycolysis
case <FTGroup:1>
Metal-binding
Manganese
end case
case <OC:Bacillaceae> and <FT:15>
Phosphoprotein
end case
case <OC:Bacillaceae>
Sporulation
end case

Gene Ontology [?]

GO:0004619; Molecular function:phosphoglycerate mutase activity
case <FTGroup:1>
GO:0030145; Molecular function:manganese ion binding
end case
GO:0006096; Biological process:glycolytic process
case <OG:Chloroplast>
GO:0009507; Cellular component:chloroplast
end case

Cross-references [?]

Pfam PF06415; iPGM_N; 1;
Pfam PF01676; Metalloenzyme; 1;
NCBIfam TIGR01307; Pgm_bpd_ind; 1;

Features [?]

From: GPMI_GEOSE (Q9X519)
Key From To Description Tag Condition FTGroup
BINDING 153 154 /ligand="substrate" R-D
BINDING 261 264 /ligand="substrate" R-x-x-R
ACT_SITE 62 62 /note="Phosphoserine intermediate" S
BINDING 12 12 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="2"		 D 1
BINDING 62 62 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="2"		 S 1
BINDING 403 403 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="1"		 D 1
BINDING 407 407 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="1"		 H 1
BINDING 444 444 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="2"		 D 1
BINDING 445 445 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="2"		 H 1
BINDING 462 462 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="1"		 H 1
BINDING 123 123 /ligand="substrate" H
BINDING 185 185 /ligand="substrate" R
BINDING 191 191 /ligand="substrate" [RK]
BINDING 336 336 /ligand="substrate" K
From: GPMI_BACSU (P39773)
Key From To Description Tag Condition FTGroup
case <OC:Bacillaceae>
MOD_RES 36 36 /note="Phosphotyrosine" Y
end case

Additional information [?]

Size range 490-552 amino acids
Related rules MF_01402
Fusion Nter: None Cter: None
Comments Possible wrong start in METMA and in the second copy of gpmI in METAC. LEPIC and LEPIN seem to be more closely related to protozoan and plant gpmI than to bacterial orthologs; not shown in alignment.



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