HAMAP rule MF_01038
General rule information
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Accession | MF_01038 |
Dates | 19-DEC-2002 (Created) 1-JUN-2023 (Last updated, Version 42) |
Name | GpmI |
Scope | Bacteria
Archaea
Plastid |
Templates | Q9X519 (GPMI_GEOSE); P39773 (GPMI_BACSU); P37689 (GPMI_ECOLI): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
|
Protein name |
|
Gene name |
|
Comments
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case <OC:Bacillaceae>
Function | Essential for rapid growth and for sporulation. Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. |
else
Function | Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. |
end case
Catalytic activity | RHEA:15901: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate
EC 5.4.2.12 |
case <FTGroup:1>
Cofactor | Mn(2+) Note: Binds 2 manganese ions per subunit. |
end case
Pathway | Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. |
case <OC:Bacteria>
Subunit | Monomer. |
end case
case <OG:Chloroplast>
Subcellular location | Plastid, chloroplast. |
end case
Similarity | Belongs to the BPG-independent phosphoglycerate mutase family. |
Keywords
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case <FTGroup:1>
end case
case <OC:Bacillaceae> and <FT:15>
end case
case <OC:Bacillaceae>
end case
Gene Ontology
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GO:0046537; Molecular function: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity.
case <FTGroup:1>
GO:0030145; Molecular function: manganese ion binding.
end case
GO:0006096; Biological process: glycolytic process.
case <OG:Chloroplast>
GO:0009507; Cellular component: chloroplast.
end case
Cross-references
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Features
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From: GPMI_GEOSE (Q9X519) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 153 | 154 | /ligand="substrate | R-D | ||||||||
BINDING | 261 | 264 | /ligand="substrate | R-x-x-R | ||||||||
ACT_SITE | 62 | 62 | Phosphoserine intermediate | S | ||||||||
BINDING | 12 | 12 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2 | D | 1 | |||||||
BINDING | 62 | 62 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2 | S | 1 | |||||||
BINDING | 403 | 403 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1 | D | 1 | |||||||
BINDING | 407 | 407 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1 | H | 1 | |||||||
BINDING | 444 | 444 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2 | D | 1 | |||||||
BINDING | 445 | 445 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2 | H | 1 | |||||||
BINDING | 462 | 462 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1 | H | 1 | |||||||
BINDING | 123 | 123 | /ligand="substrate | H | ||||||||
BINDING | 185 | 185 | /ligand="substrate | R | ||||||||
BINDING | 191 | 191 | /ligand="substrate | [RK] | ||||||||
BINDING | 336 | 336 | /ligand="substrate | K |
case <OC:Bacillaceae>
From: GPMI_BACSU (P39773) | ||||||||||||
MOD_RES | 36 | 36 | Phosphotyrosine | Y |
end case
Additional information
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Size range | 490-552 amino acids |
Related rules | MF_01402 (APGM) |
Fusion | None |
Comments | Possible wrong start in METMA and in the second copy of gpmI in METAC. LEPIC and LEPIN seem to be more closely related to protozoan and plant gpmI than to bacterial orthologs; not shown in alignment. |