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HAMAP rule MF_01090

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General rule information [?]

Accession MF_01090
Dates 27-NOV-2003 (Created)
12-MAR-2024 (Last updated, Version 20)
Name HMD
Scope(s) Archaea
Template(s) Q02394 (HMD_METKA); P32440 (HMD_METTM); Q50759 (HMD_METTL); [ Recover all ]
Triggered by HAMAP; MF_01090 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier HMD
Protein name RecName: Full=5,10-methenyltetrahydromethanopterin hydrogenase;
                 EC=1.12.98.2;
AltName: Full=H(2)-dependent methylene-H(4)MPT dehydrogenase;
AltName: Full=H(2)-forming N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase;
AltName: Full=N(5),N(10)-methenyltetrahydromethanopterin hydrogenase;
Gene name Name=hmd;

Comments [?]

case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
FUNCTIONCatalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.
end case
CATALYTIC ACTIVITY Reaction=5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2 = 5,10- methylenetetrahydromethanopterin + H(+); Xref=Rhea:RHEA:20017, ChEBI:CHEBI:15378, ChEBI:CHEBI:18276, ChEBI:CHEBI:57818, ChEBI:CHEBI:58337; EC=1.12.98.2;
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
PATHWAYOne-carbon metabolism; methanogenesis from CO(2); 5,10- methylene-5,6,7,8-tetrahydromethanopterin from 5,10-methenyl-5,6,7,8- tetrahydromethanopterin (hydrogen route): step 1/1.
end case
SIMILARITYBelongs to the HMD family.

Keywords [?]

case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
Methanogenesis
end case
One-carbon metabolism
Oxidoreductase

Gene Ontology [?]

GO:0047068; Molecular function:N5,N10-methenyltetrahydromethanopterin hydrogenase activity
GO:0006730; Biological process:one-carbon metabolic process
case <OCellular component:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
GO:0019386; Biological process:methanogenesis, from carbon dioxide
end case

Cross-references [?]

Pfam PF03201; HMD; 1;
NCBIfam TIGR01723; hmd_TIGR; 1;

Features [?]


Additional information [?]

Size range 343-358 amino acids
Related rules None
Fusion Nter: None Cter: None



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