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HAMAP rule MF_01091

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General rule information [?]

Accession MF_01091
Dates 27-NOV-2003 (Created)
1-JUN-2023 (Last updated, Version 28)
Name F420_mer
Scope(s) Archaea
Template(s) Q8TXY4 (MER_METKA); O27784 (MER_METTH); Q50744 (MER_METTM); [ Recover all ]
Triggered by HAMAP; MF_01091 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MER
Protein name RecName: Full=5,10-methylenetetrahydromethanopterin reductase;
AltName: Full=Coenzyme F420-dependent N(5),N(10)-methylenetetrahydromethanopterin reductase;
AltName: Full=Methylene-H(4)MPT reductase;
Gene name Name=mer;

Comments [?]

case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
FUNCTIONCatalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
FUNCTIONCatalyzes the oxidation of methyl-H(4)MPT to methylene- H(4)MPT.
end case
CATALYTIC ACTIVITY Reaction=5-methyl-5,6,7,8-tetrahydromethanopterin + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = 5,10- methylenetetrahydromethanopterin + reduced coenzyme F420-(gamma-L- Glu)(n); Xref=Rhea:RHEA:21144, Rhea:RHEA-COMP:12939, Rhea:RHEA- COMP:14378, ChEBI:CHEBI:15378, ChEBI:CHEBI:57818, ChEBI:CHEBI:58116, ChEBI:CHEBI:133980, ChEBI:CHEBI:139511; EC=;
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
PATHWAYOne-carbon metabolism; methanogenesis from CO(2); methyl- coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step 1/2.
end case
case <OC:Archaeoglobales>
PATHWAYMetabolic intermediate metabolism; lactate oxidation.
end case
SIMILARITYBelongs to the mer family.

Keywords [?]

case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
end case
One-carbon metabolism

Gene Ontology [?]

GO:0018537; Molecular function:coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity
GO:0006730; Biological process:one-carbon metabolic process
case <OCellular component:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
GO:0015948; Biological process:methanogenesis
end case
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00296; Bac_luciferase; 1;
NCBIfam TIGR03555; F420_mer; 1;

Features [?]

Additional information [?]

Size range 321-349 amino acids
Related rules None
Fusion Nter: None Cter: None

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