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Annotation rule MF_01091
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General rule information [?]

Accession MF_01091
Dates 27-NOV-2003 (Created)
19-NOV-2019 (Last updated, Version 26)
Name F420_mer
Templates Q8TXY4 (MER_METKA); O27784 (MER_METTH); Q50744 (MER_METTM): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=5,10-methylenetetrahydromethanopterin reductase;
AltName: Full=Coenzyme F420-dependent N(5),N(10)-methylenetetrahydromethanopterin reductase;
AltName: Full=Methylene-H(4)MPT reductase;
Gene name

Comments [?]

case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
Function Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
Function Catalyzes the oxidation of methyl-H(4)MPT to methylene-H(4)MPT.
end case
Catalytic activity RHEA:21144: 5-methyl-5,6,7,8-tetrahydromethanopterin + H(+) + oxidized coenzyme F420-(gamma-Glu)(n) = 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420-(gamma-Glu)(n)
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
Pathway One-carbon metabolism; methanogenesis from CO(2); methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step 1/2.
end case
case <OC:Archaeoglobales>
Pathway Metabolic intermediate metabolism; lactate oxidation.
end case
Subcellular location Cytoplasm.
Similarity Belongs to the mer family.

Keywords [?]

case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
end case

Gene Ontology [?]

GO:0018537; Molecular function: coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity.
GO:0006730; Biological process: one-carbon metabolic process.
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
GO:0015948; Biological process: methanogenesis.
end case
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00296; Bac_luciferase; 1;
TIGRFAMs TIGR03555; F420_mer; 1;

Additional information [?]

Size range 321-349 amino acids
Related rules None
Fusion None