HAMAP rule MF_01091
General rule information
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| Accession | MF_01091 |
| Dates | 27-NOV-2003 (Created)
4-SEP-2024 (Last updated, Version 32) |
| Name | F420_mer |
| Scope(s) |
Archaea |
| Template(s) | Q8TXY4 (MER_METKA); O27784 (MER_METTH); Q50744 (MER_METTM); [ Recover all ] |
| Triggered by |
HAMAP; MF_01091 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MER |
| Protein name | RecName: Full=5,10-methylenetetrahydromethanopterin reductase; EC=1.5.98.2; AltName: Full=Coenzyme F420-dependent N(5),N(10)-methylenetetrahydromethanopterin reductase; AltName: Full=Methylene-H(4)MPT reductase; |
| Gene name | Name=mer; |
Comments
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| case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> | |
| FUNCTION | Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT. |
| else | |
| FUNCTION | Catalyzes the oxidation of methyl-H(4)MPT to methylene- H(4)MPT. |
| end case | |
| CATALYTIC ACTIVITY | Reaction=5-methyl-5,6,7,8-tetrahydromethanopterin + oxidized coenzyme F420-(gamma-L-Glu)(n) + H(+) = 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n); Xref=Rhea:RHEA:21144, Rhea:RHEA-COMP:12939, Rhea:RHEA- COMP:14378, ChEBI:CHEBI:15378, ChEBI:CHEBI:57818, ChEBI:CHEBI:58116, ChEBI:CHEBI:133980, ChEBI:CHEBI:139511; EC=1.5.98.2; |
| case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> | |
| PATHWAY | One-carbon metabolism; methanogenesis from CO(2); methyl- coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step 1/2. |
| end case | |
| case <OC:Archaeoglobales> | |
| PATHWAY | Metabolic intermediate metabolism; lactate oxidation. |
| end case | |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the mer family. |
Keywords
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| case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> | |
| Methanogenesis | |
| end case | |
| Cytoplasm | |
| One-carbon metabolism | |
| Oxidoreductase | |
Gene Ontology
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| GO:0018537; Molecular function:coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity | |
| GO:0006730; Biological process:one-carbon metabolic process | |
| case <OCellular component:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> | |
| GO:0019386; Biological process:methanogenesis, from carbon dioxide | |
| end case | |
| case <OCellular component:Archaeoglobales> | |
| GO:0006089; Biological process:lactate metabolic process | |
| end case | |
| GO:0005737; Cellular component:cytoplasm | |
Cross-references
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Features
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Additional information
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| Size range | 321-349 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |