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HAMAP rule MF_01093

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General rule information [?]

Accession MF_01093
Dates 27-NOV-2003 (Created)
12-MAR-2024 (Last updated, Version 31)
Name MtrA
Scope(s) Archaea
Template(s) P80184 (MTRA1_METTM); [ Recover all ]
Triggered by HAMAP; MF_01093 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MTRA
Protein name RecName: Full=Tetrahydromethanopterin S-methyltransferase subunit A;
                 EC=2.1.1.86;
AltName: Full=N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit A;
Gene name Name=mtrA;

Comments [?]

FUNCTIONPart of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
CATALYTIC ACTIVITY Reaction=5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out); Xref=Rhea:RHEA:53492, ChEBI:CHEBI:29101, ChEBI:CHEBI:58103, ChEBI:CHEBI:58116, ChEBI:CHEBI:58286, ChEBI:CHEBI:58319; EC=2.1.1.86;
COFACTOR Name=5-hydroxybenzimidazolylcob(I)amide; Xref=ChEBI:CHEBI:60494; Note=Binds 1 5-hydroxybenzimidazolylcobamide group.;
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
PATHWAYOne-carbon metabolism; methanogenesis from CO(2); methyl- coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step 2/2.
end case
SUBUNITThe complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.
SUBCELLULAR LOCATIONCell membrane; Single-pass membrane protein.
SIMILARITYBelongs to the MtrA family.

Keywords [?]

case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
Methanogenesis
end case
One-carbon metabolism
Transferase
Methyltransferase
Cobalt
Cell membrane
Membrane
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0030269; Molecular function:tetrahydromethanopterin S-methyltransferase activity
GO:0006730; Biological process:one-carbon metabolic process
case <OCellular component:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
GO:0019386; Biological process:methanogenesis, from carbon dioxide
end case
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF04208; MtrA; 1;
NCBIfam TIGR01111; MtrA; 1;
General Transmembrane; -; 1;
ADD_TOPO_DOMAIN Cytoplasmic; -; 1;
ADD_TOPO_DOMAIN Extracellular; -; 1;

Features [?]

From: MTRA1_METTM (P80184)
Key From To Description Tag Condition FTGroup
BINDING 84 84 /ligand="5-hydroxybenzimidazolylcob(I)amide"
/ligand_id="ChEBI:CHEBI:60494"
/ligand_note="cofactor"
H

Additional information [?]

Size range 183-262 amino acids
Related rules None
Fusion Nter: None Cter: None



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