HAMAP logo

HAMAP rule MF_01093

Send feedback

General rule information [?]

Accession MF_01093
Dates 27-NOV-2003 (Created)
1-JUN-2023 (Last updated, Version 30)
Name MtrA
Template P80184 (MTRA1_METTM)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Tetrahydromethanopterin S-methyltransferase subunit A;
AltName: Full=N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit A;
Gene name

Comments [?]

Function Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
Catalytic activity RHEA:53492: 5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out)
Cofactor 5-hydroxybenzimidazolylcob(I)amide
Note: Binds 1 5-hydroxybenzimidazolylcobamide group.
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
Pathway One-carbon metabolism; methanogenesis from CO(2); methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step 2/2.
end case
Subunit The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.
Subcellular location Cell membrane; Single-pass membrane protein.
Similarity Belongs to the MtrA family.

Keywords [?]

case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
end case

Gene Ontology [?]

GO:0030269; Molecular function: tetrahydromethanopterin S-methyltransferase activity.
GO:0006730; Biological process: one-carbon metabolic process.
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
GO:0015948; Biological process: methanogenesis.
end case
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF04208; MtrA; 1;
NCBIfam TIGR01111; MtrA; 1;

Computed features [?]

General Transmembrane; -; 1; trigger=yes;
ADD_TOPO_DOMAIN Cytoplasmic; -; 1; trigger=yes;
Extracellular; -; 1; trigger=yes;

Features [?]

From: MTRA1_METTM (P80184)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     84     84       /ligand="5-hydroxybenzimidazolylcob(I)amide" /ligand_id="ChEBI:CHEBI:60494" /ligand_note="cofactor     H  

Additional information [?]

Size range 183-262 amino acids
Related rules None
Fusion None