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Annotation rule MF_01093 |
General rule information
[?]
Accession |
MF_01093 |
Dates |
27-NOV-2003 (Created) 19-NOV-2019 (Last updated, Version 27) |
Propagated annotation
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Identifier, protein and gene names
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Protein name |
RecName:
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Full=Tetrahydromethanopterin S-methyltransferase subunit A;
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EC 2.1.1.86;
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AltName:
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Full=N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit A;
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Function |
Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. |
Catalytic activity |
RHEA:53492: 5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out)
EC 2.1.1.86
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Cofactor |
5-hydroxybenzimidazolylcob(I)amide Note: Binds 1 5-hydroxybenzimidazolylcobamide group. |
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
Pathway |
One-carbon metabolism; methanogenesis from CO(2); methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step 2/2. |
end case
Subunit |
The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. |
Subcellular location |
Cell membrane; Single-pass membrane protein. |
Similarity |
Belongs to the MtrA family. |
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
end case
GO:0030269; Molecular function: tetrahydromethanopterin S-methyltransferase activity.
GO:0006730; Biological process: one-carbon metabolic process.
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
end case
General |
Transmembrane; -; 1; trigger=yes; |
ADD_TOPO_DOMAIN |
Cytoplasmic; -; 1; trigger=yes; |
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Extracellular; -; 1; trigger=yes; |
From: MTRA1_METTM (P80184) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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BINDING
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84
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84
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5'-hydroxybenzimidazolyl-cobamide cofactor
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H
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Additional information
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Size range |
183-262 amino acids |
Related rules |
None |
Fusion |
None |