HAMAP rule MF_01093

General rule information [?]

Accession	MF_01093
Dates	27-NOV-2003 (Created) 1-JUN-2023 (Last updated, Version 30)

Name

MtrA

Scope

Archaea

Template

P80184 (MTRA1_METTM)

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

MTRA

Protein name

RecName:		Full=Tetrahydromethanopterin S-methyltransferase subunit A;
		EC 2.1.1.86;
AltName:		Full=N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit A;

Gene name

mtrA

Comments [?]

Function	Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
Catalytic activity	RHEA:53492: 5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out) EC 2.1.1.86
Cofactor	5-hydroxybenzimidazolylcob(I)amide Note: Binds 1 5-hydroxybenzimidazolylcobamide group.

case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>

Pathway

One-carbon metabolism; methanogenesis from CO(2); methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step 2/2.

end case

Subunit	The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.
Subcellular location	Cell membrane; Single-pass membrane protein.
Similarity	Belongs to the MtrA family.

Keywords [?]

case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>

end case

Gene Ontology [?]

GO:0030269; Molecular function: tetrahydromethanopterin S-methyltransferase activity.
GO:0006730; Biological process: one-carbon metabolic process.

case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>

GO:0015948; Biological process: methanogenesis.

end case

GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam	PF04208; MtrA; 1;
NCBIfam	TIGR01111; MtrA; 1;

Computed features [?]

Features [?]

From: MTRA1_METTM (P80184)

Key From To Description Tag Condition FTGroup

BINDING 84 84 /ligand="5-hydroxybenzimidazolylcob(I)amide" /ligand_id="ChEBI:CHEBI:60494" /ligand_note="cofactor H

Additional information [?]