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Annotation rule MF_01093
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General rule information [?]

Accession MF_01093
Dates 27-NOV-2003 (Created)
19-NOV-2019 (Last updated, Version 27)
Name MtrA
Scope
Archaea
Template P80184 (MTRA1_METTM)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MTRA
Protein name
RecName: Full=Tetrahydromethanopterin S-methyltransferase subunit A;
EC 2.1.1.86;
AltName: Full=N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit A;
Gene name
mtrA

Comments [?]

Function Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
Catalytic activity RHEA:53492: 5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out)
EC 2.1.1.86
Cofactor 5-hydroxybenzimidazolylcob(I)amide
Note: Binds 1 5-hydroxybenzimidazolylcobamide group.
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
Pathway One-carbon metabolism; methanogenesis from CO(2); methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step 2/2.
end case
Subunit The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.
Subcellular location Cell membrane; Single-pass membrane protein.
Similarity Belongs to the MtrA family.

Keywords [?]

case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
Methanogenesis
end case
One-carbon metabolism
Transferase
Methyltransferase
Cobalt
Cell membrane
Membrane
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0030269; Molecular function: tetrahydromethanopterin S-methyltransferase activity.
GO:0006730; Biological process: one-carbon metabolic process.
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
GO:0015948; Biological process: methanogenesis.
end case
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF04208; MtrA; 1;
TIGRFAMs TIGR01111; MtrA; 1;

Computed features [?]

General Transmembrane; -; 1; trigger=yes;
ADD_TOPO_DOMAIN Cytoplasmic; -; 1; trigger=yes;
Extracellular; -; 1; trigger=yes;

Features [?]

From: MTRA1_METTM (P80184)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     84     84       5'-hydroxybenzimidazolyl-cobamide cofactor     H  

Additional information [?]

Size range 183-262 amino acids
Related rules None
Fusion None


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