HAMAP rule MF_01093
General rule information
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Accession | MF_01093 |
Dates | 27-NOV-2003 (Created)
1-JUN-2023 (Last updated, Version 30) |
Name | MtrA |
Scope(s) |
Archaea |
Template(s) | P80184 (MTRA1_METTM); [ Recover all ] |
Triggered by |
HAMAP; MF_01093 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | MTRA |
Protein name | RecName: Full=Tetrahydromethanopterin S-methyltransferase subunit A; EC=2.1.1.86; AltName: Full=N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit A; |
Gene name | Name=mtrA; |
Comments
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FUNCTION | Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. |
CATALYTIC ACTIVITY | Reaction=5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out); Xref=Rhea:RHEA:53492, ChEBI:CHEBI:29101, ChEBI:CHEBI:58103, ChEBI:CHEBI:58116, ChEBI:CHEBI:58286, ChEBI:CHEBI:58319; EC=2.1.1.86; |
COFACTOR | Name=5-hydroxybenzimidazolylcob(I)amide; Xref=ChEBI:CHEBI:60494; Note=Binds 1 5-hydroxybenzimidazolylcobamide group.; |
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> | |
PATHWAY | One-carbon metabolism; methanogenesis from CO(2); methyl- coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step 2/2. |
end case | |
SUBUNIT | The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. |
SUBCELLULAR LOCATION | Cell membrane; Single-pass membrane protein. |
SIMILARITY | Belongs to the MtrA family. |
Keywords
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case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> | |
Methanogenesis | |
end case | |
One-carbon metabolism | |
Transferase | |
Methyltransferase | |
Cobalt | |
Cell membrane | |
Membrane | |
Transmembrane | |
Transmembrane helix |
Gene Ontology
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GO:0030269; Molecular function:tetrahydromethanopterin S-methyltransferase activity | |
GO:0006730; Biological process:one-carbon metabolic process | |
case <OCellular component:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> | |
GO:0015948; Biological process:methanogenesis | |
end case | |
GO:0005886; Cellular component:plasma membrane |
Cross-references
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Pfam | PF04208; MtrA; 1; |
NCBIfam | TIGR01111; MtrA; 1; |
General | Transmembrane; -; 1; |
ADD_TOPO_DOMAIN | Cytoplasmic; -; 1; |
ADD_TOPO_DOMAIN | Extracellular; -; 1; |
Features
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From: MTRA1_METTM (P80184) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 84 | 84 | /ligand="5-hydroxybenzimidazolylcob(I)amide" /ligand_id="ChEBI:CHEBI:60494" /ligand_note="cofactor" |
H |
Additional information
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Size range | 183-262 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |