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HAMAP rule MF_01107

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General rule information [?]

Accession MF_01107
Dates 11-FEB-2003 (Created)
1-JUN-2023 (Last updated, Version 55)
Name ArgD_aminotrans_3
Scope(s) Bacteria
Template(s) P18335 (ARGD_ECOLI); P40732 (ARGD_SALTY); O66442 (ARGD_AQUAE); [ Recover all ]
Triggered by HAMAP; MF_01107 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ARGD
case <OC:Enterobacterales>
Protein name RecName: Full=Acetylornithine/succinyldiaminopimelate aminotransferase;
                 Short=Succinyldiaminopimelate transferase;
Gene name Name=argD; Synonyms=dapC;
Protein name RecName: Full=Acetylornithine aminotransferase;
Gene name Name=argD;
end case

Comments [?]

case <OC:Enterobacterales>
FUNCTIONInvolved in both the arginine and lysine biosynthetic pathways.
end case
CATALYTIC ACTIVITY Reaction=2-oxoglutarate + N(2)-acetyl-L-ornithine = L-glutamate + N- acetyl-L-glutamate 5-semialdehyde; Xref=Rhea:RHEA:18049, ChEBI:CHEBI:16810, ChEBI:CHEBI:29123, ChEBI:CHEBI:29985, ChEBI:CHEBI:57805; EC=;
case <OC:Enterobacterales>
CATALYTIC ACTIVITY Reaction=2-oxoglutarate + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate = (S)-2-succinylamino-6-oxoheptanedioate + L-glutamate; Xref=Rhea:RHEA:11960, ChEBI:CHEBI:15685, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:58087; EC=;
end case
COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Note=Binds 1 pyridoxal phosphate per subunit.;
PATHWAYAmino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl- L-ornithine from L-glutamate: step 4/4.
case <OC:Enterobacterales>
PATHWAYAmino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 2/3.
end case
case not <OC:Enterobacterales>
MISCELLANEOUSMay also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.
end case
SIMILARITYBelongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.

Keywords [?]

Gene Ontology [?]

GO:0003992; Molecular function:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
case <OCellular component:Enterobacterales>
GO:0009016; Molecular function:succinyldiaminopimelate transaminase activity
GO:0009085; Biological process:lysine biosynthetic process
end case
GO:0006526; Biological process:arginine biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00202; Aminotran_3; 1;
NCBIfam TIGR00707; ArgD; 1;

Features [?]

From: ARGD_ECOLI (P18335)
Key From To Description Tag Condition FTGroup
BINDING 108 109 /ligand="pyridoxal 5'-phosphate"
BINDING 226 229 /ligand="pyridoxal 5'-phosphate"
BINDING 141 141 /ligand="pyridoxal 5'-phosphate"
BINDING 144 144 /ligand="N(2)-acetyl-L-ornithine"
BINDING 283 283 /ligand="N(2)-acetyl-L-ornithine"
BINDING 284 284 /ligand="pyridoxal 5'-phosphate"
MOD_RES 255 255 /note="N6-(pyridoxal phosphate)lysine" K

Additional information [?]

Size range 360-480 amino acids
Related rules MF_01173
Fusion Nter: None Cter: None

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