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HAMAP rule MF_01107

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General rule information [?]

Accession MF_01107
Dates 11-FEB-2003 (Created)
1-JUN-2023 (Last updated, Version 55)
Name ArgD_aminotrans_3
Scope
Bacteria
Archaea
Templates P18335 (ARGD_ECOLI); P40732 (ARGD_SALTY); O66442 (ARGD_AQUAE): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
ARGD
case <OC:Enterobacterales>
Protein name
RecName: Full=Acetylornithine/succinyldiaminopimelate aminotransferase;
Short=ACOAT;
Short=DapATase;
Short=Succinyldiaminopimelate transferase;
EC 2.6.1.11;
EC 2.6.1.17;
Gene name
argD, dapC
else
Protein name
RecName: Full=Acetylornithine aminotransferase;
Short=ACOAT;
EC 2.6.1.11;
Gene name
argD
end case

Comments [?]

case <OC:Enterobacterales>
Function Involved in both the arginine and lysine biosynthetic pathways.
end case
Catalytic activity RHEA:18049: 2-oxoglutarate + N(2)-acetyl-L-ornithine = L-glutamate + N-acetyl-L-glutamate 5-semialdehyde
EC 2.6.1.11
case <OC:Enterobacterales>
Catalytic activity RHEA:11960: 2-oxoglutarate + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate = (S)-2-succinylamino-6-oxoheptanedioate + L-glutamate
EC 2.6.1.17
end case
Cofactor pyridoxal 5'-phosphate
Note: Binds 1 pyridoxal phosphate per subunit.
Pathway Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.
case <OC:Enterobacterales>
Pathway Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 2/3.
end case
Subunit Homodimer.
Subcellular location Cytoplasm.
case not <OC:Enterobacterales>
Miscellaneous May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.
end case
Similarity Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.

Keywords [?]

Cytoplasm
Amino-acid biosynthesis
Arginine biosynthesis
case <OC:Enterobacterales>
Lysine biosynthesis
end case
Transferase
Aminotransferase
Pyridoxal phosphate

Gene Ontology [?]

GO:0003992; Molecular function: N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity.
case <OC:Enterobacterales>
GO:0009016; Molecular function: succinyldiaminopimelate transaminase activity.
GO:0009085; Biological process: lysine biosynthetic process.
end case
GO:0006526; Biological process: arginine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00202; Aminotran_3; 1;
NCBIfam TIGR00707; ArgD; 1;
PROSITE PS00600; AA_TRANSFER_CLASS_3; 1;

Features [?]

From: ARGD_ECOLI (P18335)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING (Optional)     108     109       /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326     G-[TA]  
BINDING (Optional)     226     229       /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326     D-E-[IV]-Q  
BINDING (Optional)     141     141       /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326     F  
BINDING (Optional)     144     144       /ligand="N(2)-acetyl-L-ornithine" /ligand_id="ChEBI:CHEBI:57805     R  
BINDING (Optional)     283     283       /ligand="N(2)-acetyl-L-ornithine" /ligand_id="ChEBI:CHEBI:57805     [ST]  
BINDING (Optional)     284     284       /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326     T  
MOD_RES     255     255       N6-(pyridoxal phosphate)lysine     K  

Additional information [?]

Size range 360-480 amino acids
Related rules MF_01173 (ASTC supersedes the current rule)
Fusion None


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