HAMAP rule MF_01107
General rule information
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| Accession | MF_01107 |
| Dates | 11-FEB-2003 (Created)
1-JUN-2023 (Last updated, Version 55) |
| Name | ArgD_aminotrans_3 |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P18335 (ARGD_ECOLI); P40732 (ARGD_SALTY); O66442 (ARGD_AQUAE); [ Recover all ] |
| Triggered by |
HAMAP; MF_01107 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | ARGD |
| case <OC:Enterobacterales> | |
| Protein name | RecName: Full=Acetylornithine/succinyldiaminopimelate aminotransferase; Short=ACOAT; Short=DapATase; Short=Succinyldiaminopimelate transferase; EC=2.6.1.11; EC=2.6.1.17; |
| Gene name | Name=argD; Synonyms=dapC; |
| else | |
| Protein name | RecName: Full=Acetylornithine aminotransferase; Short=ACOAT; EC=2.6.1.11; |
| Gene name | Name=argD; |
| end case | |
Comments
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| case <OC:Enterobacterales> | |
| FUNCTION | Involved in both the arginine and lysine biosynthetic pathways. |
| end case | |
| CATALYTIC ACTIVITY | Reaction=2-oxoglutarate + N(2)-acetyl-L-ornithine = L-glutamate + N- acetyl-L-glutamate 5-semialdehyde; Xref=Rhea:RHEA:18049, ChEBI:CHEBI:16810, ChEBI:CHEBI:29123, ChEBI:CHEBI:29985, ChEBI:CHEBI:57805; EC=2.6.1.11; |
| case <OC:Enterobacterales> | |
| CATALYTIC ACTIVITY | Reaction=2-oxoglutarate + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate = (S)-2-succinylamino-6-oxoheptanedioate + L-glutamate; Xref=Rhea:RHEA:11960, ChEBI:CHEBI:15685, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:58087; EC=2.6.1.17; |
| end case | |
| COFACTOR | Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Note=Binds 1 pyridoxal phosphate per subunit.; |
| PATHWAY | Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl- L-ornithine from L-glutamate: step 4/4. |
| case <OC:Enterobacterales> | |
| PATHWAY | Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 2/3. |
| end case | |
| SUBUNIT | Homodimer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| case not <OC:Enterobacterales> | |
| MISCELLANEOUS | May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis. |
| end case | |
| SIMILARITY | Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. |
Keywords
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| Cytoplasm | |
| Amino-acid biosynthesis | |
| Arginine biosynthesis | |
| case <OC:Enterobacterales> | |
| Lysine biosynthesis | |
| end case | |
| Transferase | |
| Aminotransferase | |
| Pyridoxal phosphate | |
Gene Ontology
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| GO:0003992; Molecular function:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity | |
| case <OCellular component:Enterobacterales> | |
| GO:0009016; Molecular function:succinyldiaminopimelate transaminase activity | |
| GO:0009085; Biological process:lysine biosynthetic process | |
| end case | |
| GO:0006526; Biological process:arginine biosynthetic process | |
| GO:0005737; Cellular component:cytoplasm | |
Cross-references
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Features
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| From: ARGD_ECOLI (P18335) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 108 | 109 | /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326" |
G-[TA] | ||||||||
| BINDING | 226 | 229 | /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326" |
D-E-[IV]-Q | ||||||||
| BINDING | 141 | 141 | /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326" |
F | ||||||||
| BINDING | 144 | 144 | /ligand="N(2)-acetyl-L-ornithine" /ligand_id="ChEBI:CHEBI:57805" |
R | ||||||||
| BINDING | 283 | 283 | /ligand="N(2)-acetyl-L-ornithine" /ligand_id="ChEBI:CHEBI:57805" |
[ST] | ||||||||
| BINDING | 284 | 284 | /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326" |
T | ||||||||
| MOD_RES | 255 | 255 | /note="N6-(pyridoxal phosphate)lysine" | K | ||||||||
Additional information
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| Size range | 360-480 amino acids |
| Related rules |
MF_01173 |
| Fusion | Nter: None Cter: None |