HAMAP rule MF_01109
General rule information
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Accession | MF_01109 |
Dates | 11-JUL-2003 (Created) 1-JUN-2023 (Last updated, Version 40) |
Name | OTCase |
Scope | Bacteria
Archaea |
Templates | P04391 (OTC1_ECOLI); P9WIT9 (OTC_MYCTU); Q8DCF5 (OTC_VIBVU): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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case defined <Property:ARGININE_BS> and not <Property:ARGININE_BS>
Identifier |
|
Protein name |
|
else
Identifier |
|
Protein name |
|
end case
case <Property:ARGININE_BS> and <OC:Enterobacterales>
Gene name |
|
end case
case <Property:ARGININE_BS> and not <OC:Enterobacterales>
Gene name |
|
end case
case not <Property:ARGININE_BS>
Gene name |
|
end case
Comments
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Catalytic activity | RHEA:19513: carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate
EC 2.1.3.3 |
case <Property:ARGININE_BS>
Pathway | Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3. |
end case
case not <Property:ARGININE_BS>
Pathway | Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. |
end case
Subcellular location | Cytoplasm. |
Similarity | Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. |
Keywords
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case <Property:ARGININE_BS>
end case
case not <Property:ARGININE_BS>
end case
Gene Ontology
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GO:0004585; Molecular function: ornithine carbamoyltransferase activity.
case <Property:ARGININE_BS>
GO:0006526; Biological process: arginine biosynthetic process.
end case
case not <Property:ARGININE_BS>
GO:0019546; Biological process: arginine deiminase pathway.
end case
GO:0005737; Cellular component: cytoplasm.
Cross-references
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Pfam | PF00185; OTCace; 1; |
PF02729; OTCace_N; 1; | |
PRINTS | PR00100; AOTCASE; 1; |
NCBIfam | TIGR00658; Orni_carb_tr; 1; |
PROSITE | PS00097; CARBAMOYLTRANSFERASE; 1; |
Features
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From: OTC1_ECOLI (P04391) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 56 | 59 | /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228 | S-[TS]-R-T | ||||||||
BINDING | 134 | 137 | /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228 | H-x(2)-Q | ||||||||
BINDING | 236 | 237 | /ligand="L-ornithine" /ligand_id="ChEBI:CHEBI:46911 | S-[MIL] | ||||||||
BINDING | 274 | 275 | /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228 | C-L | ||||||||
BINDING | 83 | 83 | /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228 | [QN] | ||||||||
BINDING | 107 | 107 | /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228 | R | ||||||||
BINDING | 168 | 168 | /ligand="L-ornithine" /ligand_id="ChEBI:CHEBI:46911 | N | ||||||||
BINDING | 232 | 232 | /ligand="L-ornithine" /ligand_id="ChEBI:CHEBI:46911 | D | ||||||||
BINDING | 320 | 320 | /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228 | [RK] |
Additional information
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Size range | 295-354 amino acids |
Related rules | MF_02102 (PTC supersedes the current rule) |
Fusion | None |
Comments | OTCases can be involved in the biosynthesis of arginine and in its catabolism, by the arginine deiminase pathway. Some bacteria possess two distinct OTCases; some do not degrade arginine using this pathway and others do not synthesize arginine. As it is impossible to distinguish between anabolic and catabolic OTCases based on sequence similarity alone, if paralogs are found in a given genome, then one is probably the anabolic enzyme and the other the catabolic one, named arcB, which is usually located in the arcABC operon. E.coli K-12 carries two genes for anabolic OTCase, argF and argI; their products interact to form a family of four trimeric isoenzymes. Only argI can be found in E.coli B, E.coli W or in other enterobacteria. |