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Annotation rule MF_01132 |
Accession | MF_01132 |
Dates | 2-FEB-2004 (Created) 26-AUG-2020 (Last updated, Version 23) |
Name | Spx |
Scope | Bacteria; Firmicutes |
Templates | O31602 (SPX_BACSU); Q2G1U6 (SPX_STAA8): [Recover all] |
Triggered by |
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Protein name |
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Gene name |
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Function | Global transcriptional regulator that plays a key role in stress response and exerts either positive or negative regulation of genes. Acts by interacting with the C-terminal domain of the alpha subunit of the RNA polymerase (RNAP). This interaction can enhance binding of RNAP to the promoter region of target genes and stimulate their transcription, or block interaction of RNAP with activator. |
Subunit | Interacts with the C-terminal domain of the alpha subunit of the RNAP. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the ArsC family. Spx subfamily. |
Pfam | PF03960; ArsC; 1; |
TIGRFAMs | TIGR01617; arsC_related; 1; |
PROSITE | PS51353; ARSC; 1; trigger=PRU01282; |
From: SPX_BACSU (O31602) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DISULFID | 10 | 13 | Redox-active | C-x-x-C |
Size range | 128-160 amino acids |
Related rules | None |
Fusion | None |