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Annotation rule MF_01132
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General rule information [?]

Accession MF_01132
Dates 2-FEB-2004 (Created)
26-AUG-2020 (Last updated, Version 23)
Name Spx
Scope
Bacteria; Firmicutes
Templates O31602 (SPX_BACSU); Q2G1U6 (SPX_STAA8): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
SPX
Protein name
RecName: Full=Global transcriptional regulator Spx;
Gene name
spx

Comments [?]

Function Global transcriptional regulator that plays a key role in stress response and exerts either positive or negative regulation of genes. Acts by interacting with the C-terminal domain of the alpha subunit of the RNA polymerase (RNAP). This interaction can enhance binding of RNAP to the promoter region of target genes and stimulate their transcription, or block interaction of RNAP with activator.
Subunit Interacts with the C-terminal domain of the alpha subunit of the RNAP.
Subcellular location Cytoplasm.
Similarity Belongs to the ArsC family. Spx subfamily.

Keywords [?]

Cytoplasm
case <FT:1>
Disulfide bond
Redox-active center
end case
Transcription
Transcription regulation

Gene Ontology [?]

GO:0006355; Biological process: regulation of transcription, DNA-templated.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF03960; ArsC; 1;
TIGRFAMs TIGR01617; arsC_related; 1;
PROSITE PS51353; ARSC; 1; trigger=PRU01282;

Features [?]

From: SPX_BACSU (O31602)
Key     From     To       Description   Tag   Condition   FTGroup
DISULFID     10     13       Redox-active     C-x-x-C  

Additional information [?]

Size range 128-160 amino acids
Related rules None
Fusion None


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