Home  |  Contact
Annotation rule MF_01133
Send feedback

General rule information [?]

Accession MF_01133
Dates 25-SEP-2003 (Created)
19-NOV-2019 (Last updated, Version 31)
Name RuBisCO_L_type3
Scope
Archaea
Templates O93627 (RBL_THEKO); Q58632 (RBL_METJA); O28635 (RBL_ARCFU); Q8THG2 (RBL_METAC): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
RBL
Protein name
RecName: Full=Ribulose bisphosphate carboxylase;
Short=RuBisCO;
EC 4.1.1.39;
Gene name
rbcL

Comments [?]

Function Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
Catalytic activity RHEA:23124: 2 (2R)-3-phosphoglycerate + 2 H(+) = CO2 + D-ribulose 1,5-bisphosphate + H2O
EC 4.1.1.39
RHEA:36631: D-ribulose 1,5-bisphosphate + O2 = (2R)-3-phosphoglycerate + 2-phosphoglycolate + 2 H(+)
case <FTGroup:1>
Cofactor Mg(2+)
Note: Binds 1 Mg(2+) ion per subunit.
end case
Subunit Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.
Miscellaneous Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
Similarity Belongs to the RuBisCO large chain family. Type III subfamily.

Keywords [?]

Carbon dioxide fixation
Lyase
Oxidoreductase
case <FTGroup:1>
Magnesium
Metal-binding
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0000287; Molecular function: magnesium ion binding.
end case
GO:0016984; Molecular function: ribulose-bisphosphate carboxylase activity.
GO:0006196; Biological process: AMP catabolic process.

Cross-references [?]

Pfam PF00016; RuBisCO_large; 1;
PF02788; RuBisCO_large_N; 1;
TIGRFAMs TIGR03326; rubisco_III; 1;

Features [?]

From: RBL_THEKO (O93627)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     367     369       Substrate binding     S-x-G  
REGION     389     392       Substrate binding     Q-x-G-G  
ACT_SITE     163     163       Proton acceptor     K  
ACT_SITE     281     281       Proton acceptor     H  
METAL     189     189       Magnesium; via carbamate group     K   1
METAL     191     191       Magnesium     D   1
METAL     192     192       Magnesium     E   1
BINDING     165     165       Substrate     K  
BINDING     282     282       Substrate     R  
BINDING     314     314       Substrate     H  
SITE     322     322       Transition state stabilizer     K  
MOD_RES     189     189       N6-carboxylysine     K  

Additional information [?]

Size range 410-450 amino acids
Related rules MF_01338 (RBL); MF_01339 (RBL2)
Fusion None


View rule in raw text format (no links)