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HAMAP rule MF_01162

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General rule information [?]

Accession MF_01162
Dates 11-APR-2005 (Created)
19-NOV-2019 (Last updated, Version 33)
Name Aas
Scope(s) Bacteria
Template(s) P31119 (AAS_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01162 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier AAS
Protein name RecName: Full=Bifunctional protein Aas;
RecName: Full=2-acylglycerophosphoethanolamine acyltransferase;
AltName: Full=2-acyl-GPE acyltransferase;
AltName: Full=Acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase;
RecName: Full=Acyl-[acyl-carrier-protein] synthetase;
AltName: Full=Acyl-ACP synthetase;
AltName: Full=Long-chain-fatty-acid--[acyl-carrier-protein] ligase;
Gene name Name=aas;

Comments [?]

FUNCTIONPlays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1.
CATALYTIC ACTIVITY Reaction=a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-[ACP] = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + holo-[ACP]; Xref=Rhea:RHEA:10304, Rhea:RHEA-COMP:9685, Rhea:RHEA-COMP:14125, ChEBI:CHEBI:64479, ChEBI:CHEBI:64612, ChEBI:CHEBI:65213, ChEBI:CHEBI:138651; EC=;
CATALYTIC ACTIVITY Reaction=a long-chain fatty acid + ATP + holo-[ACP] = a long-chain fatty acyl-[ACP] + AMP + diphosphate; Xref=Rhea:RHEA:45588, Rhea:RHEA-COMP:9685, Rhea:RHEA-COMP:12682, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57560, ChEBI:CHEBI:64479, ChEBI:CHEBI:133243, ChEBI:CHEBI:456215; EC=;
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATIONCell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein.
end case
SIMILARITYIn the N-terminal section; belongs to the 2-acyl-GPE acetyltransferase family.
SIMILARITYIn the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family.

Keywords [?]

Gene Ontology [?]

GO:0008779; Molecular function:acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity
GO:0008922; Molecular function:long-chain fatty acid [acyl-carrier-protein] ligase activity
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF01553; Acyltransferase; 1;
Pfam PF00501; AMP-binding; 1;

Features [?]

From: AAS_ECOLI (P31119)
Key From To Description Tag Condition FTGroup
TRANSMEM 258 277 /note="Helical"
TRANSMEM 409 433 /note="Helical"
REGION 15 138 /note="Acyltransferase"
REGION 233 646 /note="AMP-binding"
ACT_SITE 36 36 H

Additional information [?]

Size range 718-738 amino acids
Related rules None
Fusion Nter: None Cter: None

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