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Annotation rule MF_01162
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General rule information [?]

Accession MF_01162
Dates 11-APR-2005 (Created)
19-NOV-2019 (Last updated, Version 33)
Name Aas
Scope
Bacteria; Enterobacterales
Template P31119 (AAS_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
AAS
Protein name
RecName: Full=Bifunctional protein Aas;
Includes:
RecName: Full=2-acylglycerophosphoethanolamine acyltransferase;
EC 2.3.1.40;
AltName: Full=2-acyl-GPE acyltransferase;
AltName: Full=Acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase;
Includes:
RecName: Full=Acyl-[acyl-carrier-protein] synthetase;
EC 6.2.1.20;
AltName: Full=Acyl-ACP synthetase;
AltName: Full=Long-chain-fatty-acid--[acyl-carrier-protein] ligase;
Gene name
aas

Comments [?]

Function Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1.
Catalytic activity RHEA:10304: a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-[ACP] = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + holo-[ACP]
EC 2.3.1.40
RHEA:45588: a long-chain fatty acid + ATP + holo-[ACP] = a long-chain fatty acyl-[ACP] + AMP + diphosphate
EC 6.2.1.20
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Multi-pass membrane protein.
end case
Similarity In the N-terminal section; belongs to the 2-acyl-GPE acetyltransferase family.
In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family.

Keywords [?]

Acyltransferase
ATP-binding
Nucleotide-binding
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Cell membrane
Ligase
Membrane
Multifunctional enzyme
Transferase
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0008779; Molecular function: acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity.
GO:0008922; Molecular function: long-chain fatty acid [acyl-carrier-protein] ligase activity.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF01553; Acyltransferase; 1;
PF00501; AMP-binding; 1;
PRINTS PR00154; AMPBINDING; 1;
PROSITE PS00455; AMP_BINDING; 1;

Features [?]

From: AAS_ECOLI (P31119)
Key     From     To       Description   Tag   Condition   FTGroup
TRANSMEM     258     277       Helical        
TRANSMEM     409     433       Helical        
REGION     15     138       Acyltransferase        
REGION     233     646       AMP-binding        
ACT_SITE     36     36             H  

Additional information [?]

Size range 718-738 amino acids
Related rules None
Fusion None


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