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Annotation rule MF_01162 |
General rule information
[?]
Accession |
MF_01162 |
Dates |
11-APR-2005 (Created) 19-NOV-2019 (Last updated, Version 33) |
Scope |
Bacteria; Enterobacterales |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Protein name |
RecName:
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Full=Bifunctional protein Aas;
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Includes:
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RecName:
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Full=2-acylglycerophosphoethanolamine acyltransferase;
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EC 2.3.1.40;
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AltName:
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Full=2-acyl-GPE acyltransferase;
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AltName:
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Full=Acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase;
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Includes:
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RecName:
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Full=Acyl-[acyl-carrier-protein] synthetase;
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EC 6.2.1.20;
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AltName:
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Full=Acyl-ACP synthetase;
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AltName:
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Full=Long-chain-fatty-acid--[acyl-carrier-protein] ligase;
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Function |
Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1. |
Catalytic activity |
RHEA:10304: a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-[ACP] = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + holo-[ACP]
EC 2.3.1.40
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RHEA:45588: a long-chain fatty acid + ATP + holo-[ACP] = a long-chain fatty acyl-[ACP] + AMP + diphosphate
EC 6.2.1.20
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case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location |
Cell membrane; Multi-pass membrane protein. |
else case <Property:Membrane=2>
Subcellular location |
Cell inner membrane; Multi-pass membrane protein. |
end case
Similarity |
In the N-terminal section; belongs to the 2-acyl-GPE acetyltransferase family. |
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In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family. |
case defined <Property:Membrane> and <Property:Membrane=2>
end case
GO:0008779; Molecular function: acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity.
GO:0008922; Molecular function: long-chain fatty acid [acyl-carrier-protein] ligase activity.
GO:0005886; Cellular component: plasma membrane.
From: AAS_ECOLI (P31119) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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TRANSMEM
|
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258
|
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277
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Helical
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TRANSMEM
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409
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433
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Helical
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REGION
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15
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138
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Acyltransferase
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REGION
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233
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646
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AMP-binding
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ACT_SITE
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36
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36
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H
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Additional information
[?]
Size range |
718-738 amino acids |
Related rules |
None |
Fusion |
None |