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| Annotation rule MF_01168 |
General rule information
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| Accession | MF_01168 |
| Dates | 8-DEC-2005 (Created) 19-NOV-2019 (Last updated, Version 13) |
| Name | AGOG |
| Scope | Archaea |
| Template | Q8ZVK6 (AGOG_PYRAE) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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Comments
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| Function | DNA repair enzyme that is part of the base excision repair (BER) pathway; protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine (GO), from single- and double-stranded DNA substrates. |
| Catalytic activity | Reaction=The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.; EC=4.2.99.18; |
| Domain | Contains two alpha-helical subdomains, with the 8-oxoguanine binding site located in a cleft at their interface. Contains a helix-hairpin-helix (HhH) structural motif and a Gly/Pro-rich sequence followed by a conserved Asp (HhH-GPD motif). |
| Similarity | Belongs to the archaeal N-glycosylase/DNA lyase (AGOG) family. |
Keywords
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Gene Ontology
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GO:0003906; Molecular function: DNA-(apurinic or apyrimidinic site) endonuclease activity.
GO:0000702; Molecular function: oxidized base lesion DNA N-glycosylase activity.
GO:0006284; Biological process: base-excision repair.
GO:0006281; Biological process: DNA repair.
GO:0000702; Molecular function: oxidized base lesion DNA N-glycosylase activity.
GO:0006284; Biological process: base-excision repair.
GO:0006281; Biological process: DNA repair.
Cross-references
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| Pfam | PF09171; DUF1886; 1; |
| PIRSF | PIRSF008955; AGOG; 1; |
Features
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| From: AGOG_PYRAE (Q8ZVK6) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 140 | 140 | Schiff-base intermediate with DNA | K | ||||||||
| ACT_SITE | 172 | 172 | D | |||||||||
| BINDING | 31 | 31 | 8-oxoguanine | Q | ||||||||
| BINDING | 58 | 58 | 8-oxoguanine; via carbonyl oxygen | S | ||||||||
| BINDING | 69 | 69 | 8-oxoguanine | W | ||||||||
| BINDING | 144 | 144 | 8-oxoguanine | F | ||||||||
| BINDING | 170 | 170 | 8-oxoguanine; via carbonyl oxygen | P | ||||||||
| BINDING | 218 | 218 | 8-oxoguanine | D | ||||||||
| BINDING | 222 | 222 | 8-oxoguanine | W | ||||||||
| REGION | 125 | 184 | Helix-hairpin-helix | |||||||||
Additional information
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| Size range | 216-291 amino acids |
| Related rules | None |
| Fusion | None |