HAMAP rule MF_01172
General rule information
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| Accession | MF_01172 |
| Dates | 3-NOV-2006 (Created)
1-JUN-2023 (Last updated, Version 22) |
| Name | AstB |
| Scope(s) |
Bacteria Pseudomonadota |
| Template(s) | P76216 (ASTB_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01172 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | ASTB |
| Protein name | RecName: Full=N-succinylarginine dihydrolase; EC=3.5.3.23; |
| Gene name | Name=astB; |
Comments
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| FUNCTION | Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)- succinylornithine, ammonia and CO(2). |
| CATALYTIC ACTIVITY | Reaction=2 H(+) + 2 H2O + N(2)-succinyl-L-arginine = CO2 + N(2)- succinyl-L-ornithine + 2 NH4(+); Xref=Rhea:RHEA:19533, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:28938, ChEBI:CHEBI:58241, ChEBI:CHEBI:58514; EC=3.5.3.23; |
| PATHWAY | Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 2/5. |
| SUBUNIT | Homodimer. |
| SIMILARITY | Belongs to the succinylarginine dihydrolase family. |
Keywords
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Gene Ontology
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| GO:0009015; Molecular function:N-succinylarginine dihydrolase activity |
| GO:0019544; Biological process:arginine catabolic process to glutamate |
Cross-references
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Features
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| From: ASTB_ECOLI (P76216) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 19 | 28 | /ligand="substrate" | |||||||||
| BINDING | 137 | 138 | /ligand="substrate" | |||||||||
| ACT_SITE | 174 | 174 | E | |||||||||
| ACT_SITE | 248 | 248 | H | |||||||||
| ACT_SITE | 365 | 365 | /note="Nucleophile" | C | ||||||||
| BINDING | 110 | 110 | /ligand="substrate" | N | ||||||||
| BINDING | 212 | 212 | /ligand="substrate" | R | ||||||||
| BINDING | 250 | 250 | /ligand="substrate" | D | ||||||||
| BINDING | 359 | 359 | /ligand="substrate" | N | ||||||||
Additional information
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| Size range | 415-449 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |