HAMAP rule MF_01180
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_01180 |
| Accession | MF_01180 |
| Dates | 15-OCT-2008 (Created)
19-NOV-2019 (Last updated, Version 13) |
| Name | FliT |
| Scope(s) |
Bacteria Enterobacterales |
| Template(s) | P0A1N2; [ Recover all ] |
| Triggered by |
HAMAP; MF_01180 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | FLIT |
| Protein name | RecName: Full=Flagellar protein FliT; |
| Gene name | Name=fliT; |
Comments
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| FUNCTION | Dual-function protein that regulates the transcription of class 2 flagellar operons and that also acts as an export chaperone for the filament-capping protein FliD. As a transcriptional regulator, acts as an anti-FlhDC factor; it directly binds FlhC, thus inhibiting the binding of the FlhC/FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus. |
| SUBUNIT | Homodimer. Interacts with FliD and FlhC. |
| SUBCELLULAR LOCATION | Cytoplasm, cytosol. |
| SIMILARITY | Belongs to the FliT family. |
Keywords
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Gene Ontology
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| GO:0005737; Cellular component:cytoplasm |
| GO:1902209; Biological process:negative regulation of bacterial-type flagellum assembly |
| GO:0006457; Biological process:protein folding |
Cross-references
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| Pfam | PF05400; FliT; 1; |
Features
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| From: FLIT_SALTY (P0A1N2) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REGION | 1 | 50 | /note="Required for homodimerization" | |||||||||
| REGION | 60 | 98 | /note="FliD binding" | |||||||||
Additional information
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| Size range | 120-126 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |