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HAMAP rule MF_01180

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General rule information [?]

Accession MF_01180
Dates 15-OCT-2008 (Created)
19-NOV-2019 (Last updated, Version 12)
Name FliT
Scope(s) Bacteria
Template(s) P0A1N2 (FLIT_SALTY); [ Recover all ]
Triggered by HAMAP; MF_01180 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier FLIT
Protein name RecName: Full=Flagellar protein FliT;
Gene name Name=fliT;

Comments [?]

FUNCTIONDual-function protein that regulates the transcription of class 2 flagellar operons and that also acts as an export chaperone for the filament-capping protein FliD. As a transcriptional regulator, acts as an anti-FlhDC factor; it directly binds FlhC, thus inhibiting the binding of the FlhC/FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus.
SUBUNITHomodimer. Interacts with FliD and FlhC.
SIMILARITYBelongs to the FliT family.

Keywords [?]

Gene Ontology [?]

GO:0005737; Cellular component:cytoplasm
GO:1902209; Biological process:negative regulation of bacterial-type flagellum assembly
GO:0006457; Biological process:protein folding

Cross-references [?]

Pfam PF05400; FliT; 1;

Features [?]

Key From To Description Tag Condition FTGroup
REGION 1 50 /note="Required for homodimerization"
REGION 60 98 /note="FliD binding"

Additional information [?]

Size range 120-126 amino acids
Related rules None
Fusion Nter: None Cter: None

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