HAMAP rule MF_01183
General rule information
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Accession | MF_01183 |
Dates | 1-DEC-2006 (Created) 26-JAN-2023 (Last updated, Version 18) |
Name | Chaperone_SurA |
Scope | Bacteria; Pseudomonadota |
Template | P0ABZ6 (SURA_ECOLI) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. |
Catalytic activity | RHEA:16237: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)
EC 5.2.1.8 |
Subcellular location | Periplasm. Note=Is capable of associating with the outer membrane. |
Domain | The PPIase activity resides only in the second parvulin domain. The N-terminal region and the C-terminal tail are necessary and sufficient for the chaperone activity of SurA. The PPIase activity is dispensable for SurA to function as a chaperone. The N-terminal region and the C-terminal tail are also required for porin recognition. |
Keywords
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Gene Ontology
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GO:0003755; Molecular function: peptidyl-prolyl cis-trans isomerase activity.
GO:0051082; Molecular function: unfolded protein binding.
GO:0006457; Biological process: protein folding.
GO:0042597; Cellular component: periplasmic space.
GO:0051082; Molecular function: unfolded protein binding.
GO:0006457; Biological process: protein folding.
GO:0042597; Cellular component: periplasmic space.
Cross-references
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PROSITE | PS01096; PPIC_PPIASE_1; 2; |
PS50198; PPIC_PPIASE_2; 2; trigger=PRU00278; | |
Pfam | PF00639; Rotamase; 2; |
Computed features
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General | Signal; -; 1; trigger=yes; |
Additional information
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Size range | 417-519 amino acids |
Related rules | None |
Fusion | None |