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Annotation rule MF_01183
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General rule information [?]

Accession MF_01183
Dates 1-DEC-2006 (Created)
19-NOV-2019 (Last updated, Version 17)
Name Chaperone_SurA
Scope
Bacteria; Proteobacteria
Template P0ABZ6 (SURA_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
SURA
Protein name
RecName: Full=Chaperone SurA;
AltName: Full=Peptidyl-prolyl cis-trans isomerase SurA;
Short=PPIase SurA;
EC 5.2.1.8;
AltName: Full=Rotamase SurA;
Flags: Precursor;
Gene name
surA

Comments [?]

Function Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation.
Catalytic activity RHEA:16237: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)
EC 5.2.1.8
Subcellular location Periplasm. Note=Is capable of associating with the outer membrane.
Domain The PPIase activity resides only in the second parvulin domain. The N-terminal region and the C-terminal tail are necessary and sufficient for the chaperone activity of SurA. The PPIase activity is dispensable for SurA to function as a chaperone. The N-terminal region and the C-terminal tail are also required for porin recognition.

Keywords [?]


Gene Ontology [?]

GO:0003755; Molecular function: peptidyl-prolyl cis-trans isomerase activity.
GO:0051082; Molecular function: unfolded protein binding.
GO:0006457; Biological process: protein folding.
GO:0042597; Cellular component: periplasmic space.

Cross-references [?]

PROSITE PS01096; PPIC_PPIASE_1; 2;
PS50198; PPIC_PPIASE_2; 2; trigger=PRU00278;
Pfam PF00639; Rotamase; 2;

Computed features [?]

General Signal; -; 1; trigger=yes;

Additional information [?]

Size range 417-519 amino acids
Related rules None
Fusion None