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HAMAP rule MF_01185

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General rule information [?]

Accession MF_01185
Dates 14-DEC-2006 (Created)
19-NOV-2019 (Last updated, Version 23)
Name FliW
Templates O83664 (FLIW_TREPA); P96503 (FLIW_BACSU); Q0P9H9 (FLIW_CAMJE); Q0P9F1 (CSRA_CAMJE): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Flagellar assembly factor FliW;
Gene name

Comments [?]

Function Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.
Subunit Interacts with translational regulator CsrA and flagellin(s).
Subcellular location Cytoplasm.
Similarity Belongs to the FliW family.

Keywords [?]

Gene Ontology [?]

GO:0044780; Biological process: bacterial-type flagellum assembly.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF02623; FliW; 1;

Additional information [?]

Size range 126-175 amino acids
Related rules None
Fusion None
Comments The ancestral operon is thought to be Fliw-CsrA, where CsrA is dedicated to controlling flagellar assembly and motility. Rounds of gene loss and re-acquisition in Gammaproteobacteria (which only rarely encode FliW) have lead to CsrA being repurposed for a larger role in translation control. See PubMed:25833324, Vakulskas et al., Microbiol. Mol. Biol. Rev. 79:193-224(2015) for a review.