HAMAP rule MF_01185
General rule information
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Accession |
MF_01185 |
Dates |
14-DEC-2006 (Created) 19-NOV-2019 (Last updated, Version 23) |
Propagated annotation
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Identifier, protein and gene names
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Protein name |
RecName:
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Full=Flagellar assembly factor FliW;
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Function |
Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum. |
Subunit |
Interacts with translational regulator CsrA and flagellin(s). |
Subcellular location |
Cytoplasm. |
Similarity |
Belongs to the FliW family. |
GO:0044780; Biological process: bacterial-type flagellum assembly.
GO:0005737; Cellular component: cytoplasm.
Additional information
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Size range |
126-175 amino acids |
Related rules |
None |
Fusion |
None |
Comments |
The ancestral operon is thought to be Fliw-CsrA, where CsrA is dedicated to controlling flagellar assembly and motility. Rounds of gene loss and re-acquisition in Gammaproteobacteria (which only rarely encode FliW) have lead to CsrA being repurposed for a larger role in translation control. See PubMed:25833324, Vakulskas et al., Microbiol. Mol. Biol. Rev. 79:193-224(2015) for a review. |