HAMAP rule MF_01185

General rule information [?]

Accession	MF_01185
Dates	14-DEC-2006 (Created) 19-NOV-2019 (Last updated, Version 23)

Name

FliW

Scope

Bacteria

Templates

O83664 (FLIW_TREPA); P96503 (FLIW_BACSU); Q0P9H9 (FLIW_CAMJE); Q0P9F1 (CSRA_CAMJE): [Recover all]

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

FLIW

Protein name

RecName:

Full=Flagellar assembly factor FliW;

Gene name

fliW

Comments [?]

Function	Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.
Subunit	Interacts with translational regulator CsrA and flagellin(s).
Subcellular location	Cytoplasm.
Similarity	Belongs to the FliW family.

Keywords [?]

Gene Ontology [?]

GO:0044780; Biological process: bacterial-type flagellum assembly.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF02623; FliW; 1;

Additional information [?]

Size range	126-175 amino acids
Related rules	None
Fusion	None
Comments	The ancestral operon is thought to be Fliw-CsrA, where CsrA is dedicated to controlling flagellar assembly and motility. Rounds of gene loss and re-acquisition in Gammaproteobacteria (which only rarely encode FliW) have lead to CsrA being repurposed for a larger role in translation control. See PubMed:25833324, Vakulskas et al., Microbiol. Mol. Biol. Rev. 79:193-224(2015) for a review.