HAMAP rule MF_01200
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_01200 |
| Accession | MF_01200 |
| Dates | 28-FEB-2005 (Created)
03-SEP-2024 (Last updated, Version 25) |
| Name | OMPdecase_type1 |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P25971; P08244; Q59654; P07691; O26232; O74110; O58462; Q9WYG7; [ Recover all ] |
| Triggered by |
case c? <OC:Bacteria>
HAMAP; MF_01200_B (Get profile general information and statistics) end case
case c? <OC:Archaea>
HAMAP; MF_01200_A (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| Identifier | PYRF |
| Protein name | RecName: Full=Orotidine 5'-phosphate decarboxylase; EC=4.1.1.23; AltName: Full=OMP decarboxylase; Short=OMPDCase; Short=OMPdecase; |
| Gene name | Name=pyrF; |
Comments
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| FUNCTION | Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP). |
| CATALYTIC ACTIVITY | Reaction=orotidine 5'-phosphate + H(+) = UMP + CO2; Xref=Rhea:RHEA:11596, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57538, ChEBI:CHEBI:57865; EC=4.1.1.23; |
| PATHWAY | Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2. |
| SUBUNIT | Homodimer. |
| SIMILARITY | Belongs to the OMP decarboxylase family. Type 1 subfamily. |
Keywords
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Gene Ontology
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| GO:0004590; Molecular function:orotidine-5'-phosphate decarboxylase activity |
| GO:0044205; Biological process:'de novo' UMP biosynthetic process |
Cross-references
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Features
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| From: PYRF_ECOLI (P08244) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Bacteria> | ||||||||||||
| BINDING | 71 | 80 | /ligand="substrate" | D-x-K-x-x-D-x-x-x-x | ||||||||
| ACT_SITE | 73 | 73 | /note="Proton donor" | K | ||||||||
| BINDING | 22 | 22 | /ligand="substrate" | D | ||||||||
| BINDING | 44 | 44 | /ligand="substrate" | K | ||||||||
| BINDING | 131 | 131 | /ligand="substrate" | T | ||||||||
| BINDING | 192 | 192 | /ligand="substrate" | R | ||||||||
| BINDING | 201 | 201 | /ligand="substrate" | Q | ||||||||
| BINDING | 221 | 221 | /ligand="substrate" | G | ||||||||
| BINDING | 222 | 222 | /ligand="substrate" | R | ||||||||
| end case | ||||||||||||
| From: PYRF_METTH (O26232) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Archaea> | ||||||||||||
| BINDING | 70 | 79 | /ligand="substrate" | D-x-K-x-x-D-x-x-x-x | ||||||||
| BINDING | 180 | 190 | /ligand="substrate" | |||||||||
| ACT_SITE | 72 | 72 | /note="Proton donor" | K | ||||||||
| BINDING | 20 | 20 | /ligand="substrate" | D | ||||||||
| BINDING | 42 | 42 | /ligand="substrate" | K | ||||||||
| BINDING | 127 | 127 | /ligand="substrate" | S | ||||||||
| BINDING | 202 | 202 | /ligand="substrate" | G | ||||||||
| BINDING | 203 | 203 | /ligand="substrate" | R | ||||||||
| end case | ||||||||||||
Additional information
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| Size range | 208-244 amino acids |
| Related rules |
MF_01215 |
| Fusion | Nter: None Cter: MF_01208 (pyrE) |
| Comments | Divergent THEMA; sequence not included in alignment and not taken into account in size range |