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Annotation rule MF_01200 |
Accession | MF_01200 |
Dates | 15-JAN-2002 (Created) 19-NOV-2019 (Last updated, Version 29) |
Name | OMPdecase_type1 |
Scope | Bacteria
Archaea |
Templates | P25971 (PYRF_BACSU); P08244 (PYRF_ECOLI); Q59654 (PYRF_PSEAE); P07691 (PYRF_SALTY); O26232 (PYRF_METTH); O74110 (PYRF_THEAC); O58462 (PYRF_PYRHO); Q9WYG7 (PYRF_THEMA): [Recover all] |
Triggered by |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP). |
Catalytic activity | RHEA:11596: H(+) + orotidine 5'-phosphate = CO2 + UMP
EC 4.1.1.23 |
Pathway | Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2. |
Subunit | Homodimer. |
Similarity | Belongs to the OMP decarboxylase family. Type 1 subfamily. |
From: PYRF_ECOLI (P08244) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
REGION | 71 | 80 | Substrate binding | D-x-K-x-x-D-x-x-x-x | ||||||||
ACT_SITE | 73 | 73 | Proton donor | K | ||||||||
BINDING | 22 | 22 | Substrate | D | ||||||||
BINDING | 44 | 44 | Substrate | K | ||||||||
BINDING | 131 | 131 | Substrate | T | ||||||||
BINDING | 192 | 192 | Substrate | R | ||||||||
BINDING | 201 | 201 | Substrate | Q | ||||||||
BINDING (Optional) | 221 | 221 | Substrate; via amide nitrogen | G | ||||||||
BINDING | 222 | 222 | Substrate | R |
From: PYRF_METTH (O26232) | ||||||||||||
REGION | 70 | 79 | Substrate binding | D-x-K-x-x-D-x-x-x-x | ||||||||
REGION | 180 | 190 | Substrate binding | |||||||||
ACT_SITE | 72 | 72 | Proton donor | K | ||||||||
BINDING | 20 | 20 | Substrate | D | ||||||||
BINDING | 42 | 42 | Substrate | K | ||||||||
BINDING | 127 | 127 | Substrate | S | ||||||||
BINDING | 202 | 202 | Substrate; via amide nitrogen | G | ||||||||
BINDING | 203 | 203 | Substrate | R |
Size range | 224-279 amino acids |
Size range | 208-244 amino acids |
Related rules | MF_01215 (PYRF) |
Fusion | Nter: None; Cter: MF_01208 (pyrE) |
Comments | Divergent THEMA; sequence not included in alignment and not taken into account in size range |