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Annotation rule MF_01200
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General rule information [?]

Accession MF_01200
Dates 15-JAN-2002 (Created)
19-NOV-2019 (Last updated, Version 29)
Name OMPdecase_type1
Scope
Bacteria
Archaea
Templates P25971 (PYRF_BACSU); P08244 (PYRF_ECOLI); Q59654 (PYRF_PSEAE); P07691 (PYRF_SALTY); O26232 (PYRF_METTH); O74110 (PYRF_THEAC); O58462 (PYRF_PYRHO); Q9WYG7 (PYRF_THEMA): [Recover all]
case <OC:Bacteria>
Triggered by
end case

case <OC:Archaea>
Triggered by
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PYRF
Protein name
RecName: Full=Orotidine 5'-phosphate decarboxylase;
EC 4.1.1.23;
AltName: Full=OMP decarboxylase;
Short=OMPDCase;
Short=OMPdecase;
Gene name
pyrF

Comments [?]

Function Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
Catalytic activity RHEA:11596: H(+) + orotidine 5'-phosphate = CO2 + UMP
EC 4.1.1.23
Pathway Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.
Subunit Homodimer.
Similarity Belongs to the OMP decarboxylase family. Type 1 subfamily.

Keywords [?]

Lyase
Decarboxylase
Pyrimidine biosynthesis

Gene Ontology [?]

GO:0004590; Molecular function: orotidine-5'-phosphate decarboxylase activity.
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process.

Cross-references [?]

PROSITE PS00156; OMPDECASE; 1;
Pfam PF00215; OMPdecase; 1;
TIGRFAMs TIGR01740; PyrF; 1;

Features [?]

case <OC:Bacteria>
From: PYRF_ECOLI (P08244)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     71     80       Substrate binding     D-x-K-x-x-D-x-x-x-x  
ACT_SITE     73     73       Proton donor     K  
BINDING     22     22       Substrate     D  
BINDING     44     44       Substrate     K  
BINDING     131     131       Substrate     T  
BINDING     192     192       Substrate     R  
BINDING     201     201       Substrate     Q  
BINDING (Optional)     221     221       Substrate; via amide nitrogen     G  
BINDING     222     222       Substrate     R  
end case
case <OC:Archaea>
From: PYRF_METTH (O26232)
REGION     70     79       Substrate binding     D-x-K-x-x-D-x-x-x-x  
REGION     180     190       Substrate binding        
ACT_SITE     72     72       Proton donor     K  
BINDING     20     20       Substrate     D  
BINDING     42     42       Substrate     K  
BINDING     127     127       Substrate     S  
BINDING     202     202       Substrate; via amide nitrogen     G  
BINDING     203     203       Substrate     R  
end case

Additional information [?]

case <OC:Bacteria>
Size range 224-279 amino acids
end case
case <OC:Archaea>
Size range 208-244 amino acids
end case
Related rules MF_01215 (PYRF)
Fusion Nter: None; Cter: MF_01208 (pyrE)
Comments Divergent THEMA; sequence not included in alignment and not taken into account in size range


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