HAMAP logo

HAMAP rule MF_01200

Send feedback

General rule information [?]

Accession MF_01200
Dates 15-JAN-2002 (Created)
1-JUN-2023 (Last updated, Version 32)
Name OMPdecase_type1
Scope(s) Bacteria
Template(s) P25971 (PYRF_BACSU); P08244 (PYRF_ECOLI); Q59654 (PYRF_PSEAE); P07691 (PYRF_SALTY); O26232 (PYRF_METTH); O74110 (PYRF_THEAC); O58462 (PYRF_PYRHO); Q9WYG7 (PYRF_THEMA); [ Recover all ]
Triggered by
case c? <OC:Bacteria>
HAMAP; MF_01200_B (Get profile general information and statistics)
end case
case c? <OC:Archaea>
HAMAP; MF_01200_A (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PYRF
RecName: Full=Orotidine 5'-phosphate decarboxylase;<br /> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;EC=<a href="https://enzyme.expasy.org/EC/"></a>;<br /> AltName: Full=OMP decarboxylase;<br /> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Short=OMPDCase;<br /> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Short=OMPdecase;
Gene name Name=pyrF;

Comments [?]

FUNCTIONCatalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
CATALYTIC ACTIVITY Reaction=H(+) + orotidine 5'-phosphate = CO2 + UMP; Xref=Rhea:RHEA:11596, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57538, ChEBI:CHEBI:57865; EC=;
PATHWAYPyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.
SIMILARITYBelongs to the OMP decarboxylase family. Type 1 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0004590; Molecular function:orotidine-5'-phosphate decarboxylase activity
GO:0006221; Biological process:pyrimidine nucleotide biosynthetic process

Cross-references [?]

Pfam PF00215; OMPdecase; 1;
NCBIfam TIGR01740; PyrF; 1;

Features [?]

From: PYRF_ECOLI (P08244)
Key From To Description Tag Condition FTGroup
case <OC:Bacteria>
BINDING 71 80 /ligand="substrate" D-x-K-x-x-D-x-x-x-x
ACT_SITE 73 73 /note="Proton donor" K
BINDING 22 22 /ligand="substrate" D
BINDING 44 44 /ligand="substrate" K
BINDING 131 131 /ligand="substrate" T
BINDING 192 192 /ligand="substrate" R
BINDING 201 201 /ligand="substrate" Q
BINDING 221 221 /ligand="substrate" G
BINDING 222 222 /ligand="substrate" R
end case
From: PYRF_METTH (O26232)
Key From To Description Tag Condition FTGroup
case <OC:Archaea>
BINDING 70 79 /ligand="substrate" D-x-K-x-x-D-x-x-x-x
BINDING 180 190 /ligand="substrate"
ACT_SITE 72 72 /note="Proton donor" K
BINDING 20 20 /ligand="substrate" D
BINDING 42 42 /ligand="substrate" K
BINDING 127 127 /ligand="substrate" S
BINDING 202 202 /ligand="substrate" G
BINDING 203 203 /ligand="substrate" R
end case

Additional information [?]

Size range 208-244 amino acids
Related rules MF_01215
Fusion Nter: None Cter: MF_01208 (pyrE)
Comments Divergent THEMA; sequence not included in alignment and not taken into account in size range

View rule in raw text format (no links)