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HAMAP rule MF_01201

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General rule information [?]

Accession MF_01201
Dates 6-FEB-2002 (Created)
1-JUN-2023 (Last updated, Version 41)
Name Ala_racemase
Scope(s) Bacteria
Template(s) P10724 (ALR_GEOSE); Q9RER4 (ALR_AQUPY); Q9S5V6 (ALR_PERPY); P10725 (ALR1_BACSU); P0A6B4 (ALR1_ECOLI); P29012 (ALR2_ECOLI); O30746 (ALR2_KLEAE); Q9FCV2 (ALR_LIMRT); G2K4Q7 (ALR_LISM4); Q9L888 (ALR_MYCAV); P94967 (ALR_MYCSM); P9WQA9 (ALR_MYCTU); Q9HUN4 (ALR1_PSEAE); Q9HTQ2 (ALR2_PSEAE); P33162 (ALR_PSEFL); Q9RAE7 (ALR2_RHIJ3); P0A1A3 (ALR1_SALTY); P06191 (ALR2_SALTY); Q932V0 (ALR1_SHIDY); Q93HP9 (ALR1_SHISO); [ Recover all ]
Triggered by HAMAP; MF_01201 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ALR
Protein name RecName: Full=Alanine racemase;

Comments [?]

FUNCTIONCatalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.
CATALYTIC ACTIVITY Reaction=L-alanine = D-alanine; Xref=Rhea:RHEA:20249, ChEBI:CHEBI:57416, ChEBI:CHEBI:57972; EC=;
COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
PATHWAYAmino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1.
SIMILARITYBelongs to the alanine racemase family.

Keywords [?]

Gene Ontology [?]

GO:0008784; Molecular function:alanine racemase activity
GO:0030170; Molecular function:pyridoxal phosphate binding
GO:0006522; Biological process:alanine metabolic process

Cross-references [?]

Pfam PF00842; Ala_racemase_C; 1;
Pfam PF01168; Ala_racemase_N; 1;
NCBIfam TIGR00492; alr; 1;

Features [?]

From: ALR_GEOSE (P10724)
Key From To Description Tag Condition FTGroup
ACT_SITE 39 39 /note="Proton acceptor; specific for D-alanine" K
ACT_SITE 265 265 /note="Proton acceptor; specific for L-alanine" Y
BINDING 136 136 /ligand="substrate" R
BINDING 312 312 /ligand="substrate" M
MOD_RES 39 39 /note="N6-(pyridoxal phosphate)lysine" K

Additional information [?]

Size range 300-470 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Annotated as alanine racemase, but could use other substrates in some organisms. In addition, it is not possible to automatically make a distinction between alr and dadX (or dadB) genes, but if these two genes are found in a genome, note that the catabolic alanine racemase dadX (which only exists in several species) is part of the dad operon (i.e. must be close to dadA gene).

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