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| Annotation rule MF_01201 |
General rule information
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| Accession | MF_01201 |
| Dates | 6-FEB-2002 (Created) 19-NOV-2019 (Last updated, Version 39) |
| Name | Ala_racemase |
| Scope | Bacteria
Archaea |
| Templates | P10724 (ALR_GEOSE); Q9RER4 (ALR_AQUPY); Q9S5V6 (ALR_PERPY); P10725 (ALR1_BACSU); P0A6B4 (ALR1_ECOLI); P29012 (ALR2_ECOLI); O30746 (ALR2_KLEAE); Q9FCV2 (ALR_LACRE); G2K4Q7 (ALR_LISM4); Q9L888 (ALR_MYCAV); P94967 (ALR_MYCSM); P9WQA9 (ALR_MYCTU); Q9HUN4 (ALR1_PSEAE); Q9HTQ2 (ALR2_PSEAE); P33162 (ALR_PSEFL); Q9RAE7 (ALR2_RHIL3); P0A1A3 (ALR1_SALTY); P06191 (ALR2_SALTY); Q932V0 (ALR1_SHIDY); Q93HP9 (ALR1_SHISO): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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Comments
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| Function | Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids. |
| Catalytic activity | RHEA:20249: L-alanine = D-alanine
EC 5.1.1.1 |
| Cofactor | pyridoxal 5'-phosphate |
| Pathway | Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. |
| Similarity | Belongs to the alanine racemase family. |
Keywords
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Gene Ontology
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GO:0008784; Molecular function: alanine racemase activity.
GO:0030170; Molecular function: pyridoxal phosphate binding.
GO:0006522; Biological process: alanine metabolic process.
GO:0030170; Molecular function: pyridoxal phosphate binding.
GO:0006522; Biological process: alanine metabolic process.
Cross-references
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| Pfam | PF00842; Ala_racemase_C; 1; |
| PF01168; Ala_racemase_N; 1; | |
| PRINTS | PR00992; ALARACEMASE; 1; |
| TIGRFAMs | TIGR00492; alr; 1; |
| PROSITE | PS00395; ALANINE_RACEMASE; 1; |
Features
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| From: ALR_GEOSE (P10724) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 39 | 39 | Proton acceptor; specific for D-alanine | K | ||||||||
| ACT_SITE | 265 | 265 | Proton acceptor; specific for L-alanine | Y | ||||||||
| BINDING (Optional) | 136 | 136 | Substrate | R | ||||||||
| BINDING (Optional) | 312 | 312 | Substrate; via amide nitrogen | M | ||||||||
| MOD_RES | 39 | 39 | N6-(pyridoxal phosphate)lysine | K | ||||||||
Additional information
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| Size range | 300-470 amino acids |
| Related rules | None |
| Fusion | None |
| Comments | Annotated as alanine racemase, but could use other substrates in some organisms. In addition, it is not possible to automatically make a distinction between alr and dadX (or dadB) genes, but if these two genes are found in a genome, note that the catabolic alanine racemase dadX (which only exists in several species) is part of the dad operon (i.e. must be close to dadA gene). |