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HAMAP rule MF_01201
General rule information
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| Accession | MF_01201 |
| Dates | 6-FEB-2002 (Created)
7-MAY-2024 (Last updated, Version 42) |
| Name | Ala_racemase |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P10724 (ALR_GEOSE); Q9RER4 (ALR_AQUPY); Q9S5V6 (ALR_PERPY); P10725 (ALR1_BACSU); P0A6B4 (ALR1_ECOLI); P29012 (ALR2_ECOLI); O30746 (ALR2_KLEAE); Q9FCV2 (ALR_LIMRT); G2K4Q7 (ALR_LISM4); Q9L888 (ALR_MYCAV); P94967 (ALR_MYCSM); P9WQA9 (ALR_MYCTU); Q9HUN4 (ALR1_PSEAE); Q9HTQ2 (ALR2_PSEAE); P33162 (ALR_PSEFL); Q9RAE7 (ALR2_RHIJ3); P0A1A3 (ALR1_SALTY); P06191 (ALR2_SALTY); Q932V0 (ALR1_SHIDY); Q93HP9 (ALR1_SHISO); [ Recover all ] |
| Triggered by |
HAMAP; MF_01201 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | ALR |
| Protein name | RecName: Full=Alanine racemase; EC=5.1.1.1; |
Comments
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| FUNCTION | Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids. |
| CATALYTIC ACTIVITY | Reaction=L-alanine = D-alanine; Xref=Rhea:RHEA:20249, ChEBI:CHEBI:57416, ChEBI:CHEBI:57972; EC=5.1.1.1; |
| COFACTOR | Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; |
| PATHWAY | Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. |
| SIMILARITY | Belongs to the alanine racemase family. |
Keywords
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Gene Ontology
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| GO:0008784; Molecular function:alanine racemase activity |
| GO:0030170; Molecular function:pyridoxal phosphate binding |
| GO:0030632; Biological process:D-alanine biosynthetic process |
Cross-references
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| Pfam | PF00842; Ala_racemase_C; 1; |
| Pfam | PF01168; Ala_racemase_N; 1; |
| PRINTS | PR00992; ALARACEMASE; 1; |
| NCBIfam | TIGR00492; alr; 1; |
| PROSITE | PS00395; ALANINE_RACEMASE; 1; |
Features
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| From: ALR_GEOSE (P10724) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 39 | 39 | /note="Proton acceptor; specific for D-alanine" | K | ||||||||
| ACT_SITE | 265 | 265 | /note="Proton acceptor; specific for L-alanine" | Y | ||||||||
| BINDING | 136 | 136 | /ligand="substrate" | R | ||||||||
| BINDING | 312 | 312 | /ligand="substrate" | M | ||||||||
| MOD_RES | 39 | 39 | /note="N6-(pyridoxal phosphate)lysine" | K | ||||||||
Additional information
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| Size range | 300-470 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Annotated as alanine racemase, but could use other substrates in some organisms. In addition, it is not possible to automatically make a distinction between alr and dadX (or dadB) genes, but if these two genes are found in a genome, note that the catabolic alanine racemase dadX (which only exists in several species) is part of the dad operon (i.e. must be close to dadA gene). |