HAMAP rule MF_01205
General rule information
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| Accession | MF_01205 |
| Dates | 11-MAR-2002 (Created)
14-MAY-2022 (Last updated, Version 40) |
| Name | YmdB |
| Scope(s) |
Bacteria Enterobacterales |
| Template(s) | P0A8D6 (YMDB_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01205 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | YMDB |
| Protein name | RecName: Full=O-acetyl-ADP-ribose deacetylase; EC=3.1.1.106; AltName: Full=Regulator of RNase III activity; |
| Gene name | Name=ymdB; |
Comments
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| FUNCTION | Deacetylates O-acetyl-ADP ribose to yield ADP-ribose and free acetate. Down-regulates ribonuclease 3 (RNase III) activity. Acts by interacting directly with the region of the ribonuclease that is required for dimerization/activation. |
| CATALYTIC ACTIVITY | Reaction=3''-O-acetyl-ADP-D-ribose + H2O = acetate + ADP-D-ribose + H(+); Xref=Rhea:RHEA:59244, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:57967, ChEBI:CHEBI:142723; EC=3.1.1.106; |
| CATALYTIC ACTIVITY | Reaction=2''-O-acetyl-ADP-D-ribose + H2O = acetate + ADP-D-ribose + H(+); Xref=Rhea:RHEA:57060, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:57967, ChEBI:CHEBI:83767; EC=3.1.1.106; |
| SUBUNIT | Homodimer. Interacts with RNase III. |
| SIMILARITY | Belongs to the YmdB family. |
Keywords
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Gene Ontology
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| GO:0001883; Molecular function:purine nucleoside binding |
| GO:0008428; Molecular function:ribonuclease inhibitor activity |
| GO:0019213; Molecular function:deacetylase activity |
| GO:0042278; Biological process:purine nucleoside metabolic process |
| GO:0060701; Biological process:negative regulation of ribonuclease activity |
Cross-references
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Features
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| From: YMDB_ECOLI (P0A8D6) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 11 | 12 | /ligand="substrate" | D-I | ||||||||
| BINDING | 33 | 35 | /ligand="substrate" | G-V-D | ||||||||
| BINDING | 122 | 126 | /ligand="substrate" | S-T-G-[IVA]-Y | ||||||||
| ACT_SITE | 35 | 35 | /note="Proton acceptor" | D | ||||||||
| BINDING | 25 | 25 | /ligand="substrate" | N | ||||||||
Additional information
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| Size range | 160-190 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | The family is restricted to Enterobacterales in order to avoid wrong matches. |