HAMAP rule MF_01205
General rule information
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Accession | MF_01205 |
Dates | 11-MAR-2002 (Created) 14-MAY-2022 (Last updated, Version 40) |
Name | YmdB |
Scope | Bacteria; Enterobacterales |
Template | P0A8D6 (YMDB_ECOLI) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Deacetylates O-acetyl-ADP ribose to yield ADP-ribose and free acetate. Down-regulates ribonuclease 3 (RNase III) activity. Acts by interacting directly with the region of the ribonuclease that is required for dimerization/activation. |
Catalytic activity | RHEA:59244: 3''-O-acetyl-ADP-D-ribose + H2O = acetate + ADP-D-ribose + H(+)
EC 3.1.1.106 |
RHEA:57060: 2''-O-acetyl-ADP-D-ribose + H2O = acetate + ADP-D-ribose + H(+)
EC 3.1.1.106 |
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Subunit | Homodimer. Interacts with RNase III. |
Similarity | Belongs to the YmdB family. |
Keywords
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Gene Ontology
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GO:0001883; Molecular function: purine nucleoside binding.
GO:0008428; Molecular function: ribonuclease inhibitor activity.
GO:0019213; Molecular function: deacetylase activity.
GO:0042278; Biological process: purine nucleoside metabolic process.
GO:0060701; Biological process: negative regulation of ribonuclease activity.
GO:0008428; Molecular function: ribonuclease inhibitor activity.
GO:0019213; Molecular function: deacetylase activity.
GO:0042278; Biological process: purine nucleoside metabolic process.
GO:0060701; Biological process: negative regulation of ribonuclease activity.
Cross-references
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Features
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From: YMDB_ECOLI (P0A8D6) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 11 | 12 | /ligand="substrate | D-I | ||||||||
BINDING | 33 | 35 | /ligand="substrate | G-V-D | ||||||||
BINDING | 122 | 126 | /ligand="substrate | S-T-G-[IVA]-Y | ||||||||
ACT_SITE | 35 | 35 | Proton acceptor | D | ||||||||
BINDING | 25 | 25 | /ligand="substrate | N |
Additional information
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Size range | 160-190 amino acids |
Related rules | None |
Fusion | None |
Comments | The family is restricted to Enterobacterales in order to avoid wrong matches. |