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HAMAP rule MF_01205

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General rule information [?]

Accession MF_01205
Dates 11-MAR-2002 (Created)
14-MAY-2022 (Last updated, Version 40)
Name YmdB
Scope(s) Bacteria
Template(s) P0A8D6 (YMDB_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01205 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier YMDB
Protein name RecName: Full=O-acetyl-ADP-ribose deacetylase;
AltName: Full=Regulator of RNase III activity;
Gene name Name=ymdB;

Comments [?]

FUNCTIONDeacetylates O-acetyl-ADP ribose to yield ADP-ribose and free acetate. Down-regulates ribonuclease 3 (RNase III) activity. Acts by interacting directly with the region of the ribonuclease that is required for dimerization/activation.
CATALYTIC ACTIVITY Reaction=3''-O-acetyl-ADP-D-ribose + H2O = acetate + ADP-D-ribose + H(+); Xref=Rhea:RHEA:59244, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:57967, ChEBI:CHEBI:142723; EC=;
CATALYTIC ACTIVITY Reaction=2''-O-acetyl-ADP-D-ribose + H2O = acetate + ADP-D-ribose + H(+); Xref=Rhea:RHEA:57060, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:57967, ChEBI:CHEBI:83767; EC=;
SUBUNITHomodimer. Interacts with RNase III.
SIMILARITYBelongs to the YmdB family.

Keywords [?]

Gene Ontology [?]

GO:0001883; Molecular function:purine nucleoside binding
GO:0008428; Molecular function:ribonuclease inhibitor activity
GO:0019213; Molecular function:deacetylase activity
GO:0042278; Biological process:purine nucleoside metabolic process
GO:0060701; Biological process:negative regulation of ribonuclease activity

Cross-references [?]

Pfam PF01661; Macro; 1;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 11 12 /ligand="substrate" D-I
BINDING 33 35 /ligand="substrate" G-V-D
BINDING 122 126 /ligand="substrate" S-T-G-[IVA]-Y
ACT_SITE 35 35 /note="Proton acceptor" D
BINDING 25 25 /ligand="substrate" N

Additional information [?]

Size range 160-190 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments The family is restricted to Enterobacterales in order to avoid wrong matches.

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