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Annotation rule MF_01205
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General rule information [?]

Accession MF_01205
Dates 11-MAR-2002 (Created)
19-NOV-2019 (Last updated, Version 38)
Name YmdB
Scope
Bacteria; Enterobacterales
Template P0A8D6 (YMDB_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
YMDB
Protein name
RecName: Full=O-acetyl-ADP-ribose deacetylase;
EC 3.1.1.106;
AltName: Full=Regulator of RNase III activity;
Gene name
ymdB

Comments [?]

Function Deacetylates O-acetyl-ADP ribose to yield ADP-ribose and free acetate. Down-regulates ribonuclease 3 (RNase III) activity. Acts by interacting directly with the region of the ribonuclease that is required for dimerization/activation.
Catalytic activity RHEA:59244: 3''-O-acetyl-ADP-D-ribose + H2O = acetate + ADP-D-ribose + H(+)
EC 3.1.1.106
RHEA:57060: 2''-O-acetyl-ADP-D-ribose + H2O = acetate + ADP-D-ribose + H(+)
EC 3.1.1.106
Subunit Homodimer. Interacts with RNase III.
Similarity Belongs to the YmdB family.

Keywords [?]


Gene Ontology [?]

GO:0001883; Molecular function: purine nucleoside binding.
GO:0008428; Molecular function: ribonuclease inhibitor activity.
GO:0019213; Molecular function: deacetylase activity.
GO:0042278; Biological process: purine nucleoside metabolic process.
GO:0060701; Biological process: negative regulation of ribonuclease activity.

Cross-references [?]

Pfam PF01661; Macro; 1;
PROSITE PS51154; MACRO; 1; trigger=PRU00490;

Features [?]

From: YMDB_ECOLI (P0A8D6)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     11     12       Substrate binding     D-I  
REGION     33     35       Substrate binding     G-V-D  
REGION     122     126       Substrate binding     S-T-G-[IVA]-Y  
ACT_SITE     35     35       Proton acceptor     D  
BINDING     25     25       Substrate     N  

Additional information [?]

Size range 160-190 amino acids
Related rules None
Fusion None
Comments The family is restricted to Enterobacterales in order to avoid wrong matches.