HAMAP logo

HAMAP rule MF_01205

Send feedback

General rule information [?]

Accession MF_01205
Dates 11-MAR-2002 (Created)
14-MAY-2022 (Last updated, Version 40)
Name YmdB
Bacteria; Enterobacterales
Template P0A8D6 (YMDB_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=O-acetyl-ADP-ribose deacetylase;
AltName: Full=Regulator of RNase III activity;
Gene name

Comments [?]

Function Deacetylates O-acetyl-ADP ribose to yield ADP-ribose and free acetate. Down-regulates ribonuclease 3 (RNase III) activity. Acts by interacting directly with the region of the ribonuclease that is required for dimerization/activation.
Catalytic activity RHEA:59244: 3''-O-acetyl-ADP-D-ribose + H2O = acetate + ADP-D-ribose + H(+)
RHEA:57060: 2''-O-acetyl-ADP-D-ribose + H2O = acetate + ADP-D-ribose + H(+)
Subunit Homodimer. Interacts with RNase III.
Similarity Belongs to the YmdB family.

Keywords [?]

Gene Ontology [?]

GO:0001883; Molecular function: purine nucleoside binding.
GO:0008428; Molecular function: ribonuclease inhibitor activity.
GO:0019213; Molecular function: deacetylase activity.
GO:0042278; Biological process: purine nucleoside metabolic process.
GO:0060701; Biological process: negative regulation of ribonuclease activity.

Cross-references [?]

Pfam PF01661; Macro; 1;
PROSITE PS51154; MACRO; 1; trigger=PRU00490;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
BINDING     11     12       /ligand="substrate     D-I  
BINDING     33     35       /ligand="substrate     G-V-D  
BINDING     122     126       /ligand="substrate     S-T-G-[IVA]-Y  
ACT_SITE     35     35       Proton acceptor     D  
BINDING     25     25       /ligand="substrate     N  

Additional information [?]

Size range 160-190 amino acids
Related rules None
Fusion None
Comments The family is restricted to Enterobacterales in order to avoid wrong matches.