HAMAP rule MF_01205

General rule information [?]

Accession	MF_01205
Dates	11-MAR-2002 (Created) 14-MAY-2022 (Last updated, Version 40)

Name

YmdB

Scope

Bacteria; Enterobacterales

Template

P0A8D6 (YMDB_ECOLI)

Triggered by

HAMAP; MF_01205 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

YMDB

Protein name

RecName:		Full=O-acetyl-ADP-ribose deacetylase;
		EC 3.1.1.106;
AltName:		Full=Regulator of RNase III activity;

Gene name

ymdB

Comments [?]

Function	Deacetylates O-acetyl-ADP ribose to yield ADP-ribose and free acetate. Down-regulates ribonuclease 3 (RNase III) activity. Acts by interacting directly with the region of the ribonuclease that is required for dimerization/activation.
Catalytic activity	RHEA:59244: 3''-O-acetyl-ADP-D-ribose + H2O = acetate + ADP-D-ribose + H(+) EC 3.1.1.106
	RHEA:57060: 2''-O-acetyl-ADP-D-ribose + H2O = acetate + ADP-D-ribose + H(+) EC 3.1.1.106
Subunit	Homodimer. Interacts with RNase III.
Similarity	Belongs to the YmdB family.

Keywords [?]

Hydrolase

Gene Ontology [?]

GO:0001883; Molecular function: purine nucleoside binding.
GO:0008428; Molecular function: ribonuclease inhibitor activity.
GO:0019213; Molecular function: deacetylase activity.
GO:0042278; Biological process: purine nucleoside metabolic process.
GO:0060701; Biological process: negative regulation of ribonuclease activity.

Cross-references [?]

Pfam	PF01661; Macro; 1;
PROSITE	PS51154; MACRO; 1; trigger=PRU00490;

Features [?]

From: YMDB_ECOLI (P0A8D6)

Key From To Description Tag Condition FTGroup

BINDING 11 12 /ligand="substrate D-I

BINDING 33 35 /ligand="substrate G-V-D

BINDING 122 126 /ligand="substrate S-T-G-[IVA]-Y

ACT_SITE 35 35 Proton acceptor D

BINDING 25 25 /ligand="substrate N

Additional information [?]

Size range	160-190 amino acids
Related rules	None
Fusion	None
Comments	The family is restricted to Enterobacterales in order to avoid wrong matches.

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