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Annotation rule MF_01210 |
Accession | MF_01210 |
Dates | 19-JUL-2002 (Created) 19-NOV-2019 (Last updated, Version 44) |
Name | CPSase_L_chain |
Scope | Bacteria
Archaea |
Templates | P00968 (CARB_ECOLI); O50302 (CARB_GEOSE); Q9ZB63 (CARY_GEOSE); O32771 (CARB_LACLM); P77886 (CARB_LACPL); Q9RLS9 (CARY_LACPL): [Recover all] |
Triggered by |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Catalytic activity | RHEA:18633: 2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate
EC 6.3.5.5 |
Pathway | Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1. |
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3. | |
Subunit | Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. |
Similarity | Belongs to the CarB family. |
Pfam | PF00289; CPSase_L_chain; 1; |
PF02142; MGS; 1; | |
PF02786; CPSase_L_D2; 1; | |
PF02787; CPSase_L_D3; 1; | |
PRINTS | PR00098; CPSASE; 1; |
PROSITE | PS00866; CPSASE_1; 1; |
PS00867; CPSASE_2; 1; | |
PS50975; ATP_GRASP; 1-2; trigger=PRU00409; | |
PS51855; MGS; 1; trigger=PRU01202; | |
TIGRFAMs | TIGR01369; CPSaseII_lrg; 1; |
From: CARB_ECOLI (P00968) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
REGION | Nter | 403 | Carboxyphosphate synthetic domain | |||||||||
REGION | 404 | 553 | Oligomerization domain | |||||||||
REGION | 554 | 936 | Carbamoyl phosphate synthetic domain | |||||||||
REGION | 937 | Cter | Allosteric domain |
From: CARB_SULTO (Q970U7) | ||||||||||||
REGION | Nter | 399 | Carboxyphosphate synthetic domain | |||||||||
REGION | 400 | 548 | Oligomerization domain | |||||||||
REGION | 549 | 930 | Carbamoyl phosphate synthetic domain | |||||||||
REGION | 931 | Cter | Allosteric domain |
Size range | 1020-1167 amino acids |
Size range | 1024-1076 amino acids |
Related rules | None |
Fusion | None |
Comments | Bacillaceae, Geobacillus and lactobacillaceae seem to posess two members of this family: one specific for arginine biosynthesis (called CARY_ in ID, and CARB in GN) and the other specific for pyrimidine synthesis (called CARB_ in ID, and PYRAB in GN). Sequence of carB is split into two genes in AQUAE, METJA and METKA. Weird insertion in NOSS1, THEMA and ZYMMO (sequences not shown in alignment). |