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Annotation rule MF_01211 |
Accession | MF_01211 |
Dates | 17-JUN-2002 (Created) 19-NOV-2019 (Last updated, Version 42) |
Name | DHODB_Fe_S_bind |
Scope | Bacteria
Archaea |
Templates | P56968 (PYRK_LACLM); P25983 (PYRK_BACSU); P0DH76 (PYRK_ENTFA): [Recover all] |
Triggered by |
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Protein name |
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Protein name |
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Gene name |
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Function | Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). |
Cofactor | [2Fe-2S] cluster Note: Binds 1 [2Fe-2S] cluster per subunit. |
FAD Note: Binds 1 FAD per subunit. |
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Pathway | Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (NAD(+) route): step 1/1. |
Subunit | Heterotetramer of 2 PyrK and 2 PyrD type B subunits. |
Similarity | Belongs to the PyrK family. |
Pfam | PF10418; DHODB_Fe-S_bind; 1; |
PF00970; FAD_binding_6; 1; | |
PF00175; NAD_binding_1; 1; | |
PIRSF | PIRSF006816; Cyc3_hyd_g; 1; |
PRINTS | PR00409; PHDIOXRDTASE; 1; |
PROSITE | PS00197; 2FE2S_FER_1; 0-1; |
PS51384; FAD_FR; 1; trigger=PRU00716; |
From: PYRK_LACLM (P56968) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
NP_BIND | 53 | 56 | FAD | R-P-x-S | ||||||||
NP_BIND (Optional) | 70 | 72 | FAD | [LIV]-x-[RQ] | ||||||||
NP_BIND | 79 | 80 | FAD | G-T |
METAL | 226 | 226 | Iron-sulfur (2Fe-2S) | C | ||||||||
METAL | 231 | 231 | Iron-sulfur (2Fe-2S) | C | ||||||||
METAL | 234 | 234 | Iron-sulfur (2Fe-2S) | C | ||||||||
METAL | 249 | 249 | Iron-sulfur (2Fe-2S) | C |
Size range | 232-266 amino acids |
Related rules | None |
Fusion | None |
Comments | Divergent THEMA and THEP1, annotated as "atypical" since they are quite divergent from the family profile, but can be thought to be PyrK proteins as the gene is adjacent to pyrD. |