HAMAP rule MF_01216
General rule information
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Accession | MF_01216 |
Dates | 24-JUN-2002 (Created) 17-JAN-2023 (Last updated, Version 41) |
Name | Azoreductase_type1 |
Scope | Bacteria |
Templates | P41407 (AZOR_ECOLI); Q9I5F3 (AZOR1_PSEAE); Q9I2E2 (AZOR2_PSEAE); Q9HZ17 (AZOR3_PSEAE); Q831B2 (AZOR_ENTFA): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones. |
Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines. | |
Catalytic activity | RHEA:65952: 2 a quinone + H(+) + NADH = 2 a 1,4-benzosemiquinone + NAD(+) |
RHEA:55872: anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) = 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH
EC 1.7.1.17 |
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Cofactor | FMN Note: Binds 1 FMN per subunit. |
Subunit | Homodimer. |
Similarity | Belongs to the azoreductase type 1 family. |
Keywords
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Gene Ontology
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GO:0009055; Molecular function: electron transfer activity.
GO:0010181; Molecular function: FMN binding.
GO:0016652; Molecular function: oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor.
GO:0010181; Molecular function: FMN binding.
GO:0016652; Molecular function: oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor.
Cross-references
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Features
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From: AZOR1_PSEAE (Q9I5F3) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 16 | 18 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210 | S-x-S | ||||||||
BINDING | 97 | 100 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210 | M-[YW]-N-[FL] | ||||||||
BINDING | 145 | 148 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210 | [ST]-x-G-G | ||||||||
BINDING | 10 | 10 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210 | S |
Additional information
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Size range | 186-240 amino acids |
Related rules | None |
Fusion | None |
Comments | Divergent STRCO and first copy in CLOAB and CLOPE; sequences not included in alignment and not taken into account in size range. In some species there are many duplicates. |