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HAMAP rule MF_01218

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General rule information [?]

Accession MF_01218
Dates 30-JUL-2002 (Created)
1-JUN-2023 (Last updated, Version 34)
Name Upp
Scope(s) Bacteria
Archaea
Template(s) P70881 (UPP_BACCL); P0A8F0 (UPP_ECOLI); Q980Q4 (UPP_SACS2); P39149 (UPP_BACSU); [ Recover all ]
Triggered by
case c? <OC:Bacteria>
HAMAP; MF_01218_B (Get profile general information and statistics)
end case
case c? <OC:Archaea>
HAMAP; MF_01218_A (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier UPP
Protein name RecName: Full=Uracil phosphoribosyltransferase;
                 EC=2.4.2.9;
AltName: Full=UMP pyrophosphorylase;
AltName: Full=UPRTase;
Gene name Name=upp;

Comments [?]

FUNCTIONCatalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate.
CATALYTIC ACTIVITY Reaction=diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil; Xref=Rhea:RHEA:13017, ChEBI:CHEBI:17568, ChEBI:CHEBI:33019, ChEBI:CHEBI:57865, ChEBI:CHEBI:58017; EC=2.4.2.9;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg- PRPP.;
ACTIVITY REGULATIONAllosterically activated by GTP.
PATHWAYPyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.
SIMILARITYBelongs to the UPRTase family.

Keywords [?]


Gene Ontology [?]

GO:0000287; Molecular function:magnesium ion binding
GO:0004845; Molecular function:uracil phosphoribosyltransferase activity
GO:0008655; Biological process:pyrimidine-containing compound salvage

Cross-references [?]

Pfam PF00156; Pribosyltran; 1;
NCBIfam TIGR01091; Upp; 1;

Features [?]

From: UPP_BACCL (P70881)
Key From To Description Tag Condition FTGroup
case <OC:Bacteria>
BINDING 131 139 /ligand="5-phospho-alpha-D-ribose 1-diphosphate"
/ligand_id="ChEBI:CHEBI:58017"
BINDING 199 201 /ligand="uracil"
/ligand_id="ChEBI:CHEBI:17568"
G-x-[AIC]
BINDING 79 79 /ligand="5-phospho-alpha-D-ribose 1-diphosphate"
/ligand_id="ChEBI:CHEBI:58017"
R
BINDING 104 104 /ligand="5-phospho-alpha-D-ribose 1-diphosphate"
/ligand_id="ChEBI:CHEBI:58017"
[RK]
BINDING 194 194 /ligand="uracil"
/ligand_id="ChEBI:CHEBI:17568"
[IV]
BINDING 200 200 /ligand="5-phospho-alpha-D-ribose 1-diphosphate"
/ligand_id="ChEBI:CHEBI:58017"
D
end case
From: UPP_SACS2 (Q980Q4)
Key From To Description Tag Condition FTGroup
case <OC:Archaea>
BINDING 30 34 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"
[KR]-x(3)-[RK]
BINDING 140 148 /ligand="5-phospho-alpha-D-ribose 1-diphosphate"
/ligand_id="ChEBI:CHEBI:58017"
BINDING 208 210 /ligand="uracil"
/ligand_id="ChEBI:CHEBI:17568"
G-x-[AIC]
BINDING 80 80 /ligand="5-phospho-alpha-D-ribose 1-diphosphate"
/ligand_id="ChEBI:CHEBI:58017"
R
BINDING 105 105 /ligand="5-phospho-alpha-D-ribose 1-diphosphate"
/ligand_id="ChEBI:CHEBI:58017"
[RK]
BINDING 203 203 /ligand="uracil"
/ligand_id="ChEBI:CHEBI:17568"
[IV]
BINDING 209 209 /ligand="5-phospho-alpha-D-ribose 1-diphosphate"
/ligand_id="ChEBI:CHEBI:58017"
D
end case

Additional information [?]

Size range 211-232 amino acids
Related rules None
Fusion Nter: <Unknown> Cter: None
Comments Divergent PORGI and TREPA; sequences not included in alignment. Possible wrong start in STRCO.



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