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HAMAP rule MF_01218

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General rule information [?]

Accession MF_01218
Dates 30-JUL-2002 (Created)
1-JUN-2023 (Last updated, Version 34)
Name Upp
Templates P70881 (UPP_BACCL); P0A8F0 (UPP_ECOLI); Q980Q4 (UPP_SACS2); P39149 (UPP_BACSU): [Recover all]
case <OC:Bacteria>
end case

case <OC:Archaea>
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Uracil phosphoribosyltransferase;
AltName: Full=UMP pyrophosphorylase;
AltName: Full=UPRTase;
Gene name

Comments [?]

Function Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
Catalytic activity RHEA:13017: diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil
Cofactor Mg(2+)
Note: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
Activity regulation Allosterically activated by GTP.
Pathway Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.
Similarity Belongs to the UPRTase family.

Keywords [?]

Gene Ontology [?]

GO:0000287; Molecular function: magnesium ion binding.
GO:0004845; Molecular function: uracil phosphoribosyltransferase activity.
GO:0008655; Biological process: pyrimidine-containing compound salvage.

Cross-references [?]

Pfam PF00156; Pribosyltran; 1;
NCBIfam TIGR01091; Upp; 1;

Features [?]

case <OC:Bacteria>
From: UPP_BACCL (P70881)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     131     139       /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017        
BINDING     199     201       /ligand="uracil" /ligand_id="ChEBI:CHEBI:17568     G-x-[AIC]  
BINDING     79     79       /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017     R  
BINDING     104     104       /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017     [RK]  
BINDING     194     194       /ligand="uracil" /ligand_id="ChEBI:CHEBI:17568     [IV]  
BINDING     200     200       /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017     D  
end case
case <OC:Archaea>
From: UPP_SACS2 (Q980Q4)
BINDING (Optional)     30     34       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565     [KR]-x(3)-[RK]  
BINDING     140     148       /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017        
BINDING     208     210       /ligand="uracil" /ligand_id="ChEBI:CHEBI:17568     G-x-[AIC]  
BINDING     80     80       /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017     R  
BINDING     105     105       /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017     [RK]  
BINDING     203     203       /ligand="uracil" /ligand_id="ChEBI:CHEBI:17568     [IV]  
BINDING     209     209       /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017     D  
end case

Additional information [?]

case <OC:Bacteria>
Size range 206-218 amino acids
end case
case <OC:Archaea>
Size range 211-232 amino acids
end case
Related rules None
Fusion Nter: <Unknown>; Cter: None
Comments Divergent PORGI and TREPA; sequences not included in alignment. Possible wrong start in STRCO.