HAMAP rule MF_01218
General rule information
[?]
| Accession | MF_01218 |
| Dates | 30-JUL-2002 (Created)
3-SEP-2024 (Last updated, Version 36) |
| Name | Upp |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P70881 (UPP_BACCL); P0A8F0 (UPP_ECOLI); Q980Q4 (UPP_SACS2); P39149 (UPP_BACSU); [ Recover all ] |
| Triggered by |
case c? <OC:Bacteria>
HAMAP; MF_01218_B (Get profile general information and statistics) end case
case c? <OC:Archaea>
HAMAP; MF_01218_A (Get profile general information and statistics) end case
|
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | UPP |
| Protein name | RecName: Full=Uracil phosphoribosyltransferase; EC=2.4.2.9; AltName: Full=UMP pyrophosphorylase; AltName: Full=UPRTase; |
| Gene name | Name=upp; |
Comments
[?]
| FUNCTION | Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. |
| CATALYTIC ACTIVITY | Reaction=UMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + uracil; Xref=Rhea:RHEA:13017, ChEBI:CHEBI:17568, ChEBI:CHEBI:33019, ChEBI:CHEBI:57865, ChEBI:CHEBI:58017; EC=2.4.2.9; |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg- PRPP.; |
| ACTIVITY REGULATION | Allosterically activated by GTP. |
| PATHWAY | Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1. |
| SIMILARITY | Belongs to the UPRTase family. |
Keywords
[?]
Gene Ontology
[?]
| GO:0000287; Molecular function:magnesium ion binding |
| GO:0004845; Molecular function:uracil phosphoribosyltransferase activity |
| GO:0044206; Biological process:UMP salvage |
Cross-references
[?]
Features
[?]
| From: UPP_BACCL (P70881) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Bacteria> | ||||||||||||
| BINDING | 131 | 139 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017" |
|||||||||
| BINDING | 199 | 201 | /ligand="uracil" /ligand_id="ChEBI:CHEBI:17568" |
G-x-[AIC] | ||||||||
| BINDING | 79 | 79 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017" |
R | ||||||||
| BINDING | 104 | 104 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017" |
[RK] | ||||||||
| BINDING | 194 | 194 | /ligand="uracil" /ligand_id="ChEBI:CHEBI:17568" |
[IV] | ||||||||
| BINDING | 200 | 200 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017" |
D | ||||||||
| end case | ||||||||||||
| From: UPP_SACS2 (Q980Q4) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Archaea> | ||||||||||||
| BINDING | 30 | 34 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" |
[KR]-x(3)-[RK] | ||||||||
| BINDING | 140 | 148 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017" |
|||||||||
| BINDING | 208 | 210 | /ligand="uracil" /ligand_id="ChEBI:CHEBI:17568" |
G-x-[AIC] | ||||||||
| BINDING | 80 | 80 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017" |
R | ||||||||
| BINDING | 105 | 105 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017" |
[RK] | ||||||||
| BINDING | 203 | 203 | /ligand="uracil" /ligand_id="ChEBI:CHEBI:17568" |
[IV] | ||||||||
| BINDING | 209 | 209 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017" |
D | ||||||||
| end case | ||||||||||||
Additional information
[?]
| Size range | 211-232 amino acids |
| Related rules |
None |
| Fusion | Nter: <Unknown> Cter: None |
| Comments | Divergent PORGI and TREPA; sequences not included in alignment. Possible wrong start in STRCO. |