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HAMAP rule MF_01230

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General rule information [?]

Accession MF_01230
Dates 5-FEB-2003 (Created)
19-NOV-2019 (Last updated, Version 17)
Name Haloalk_dehal_type1
Scope(s) Bacteria
Template(s) P22643 (DHLA_XANAU); Q93K00 (DHMA_MYCAV); [ Recover all ]
Triggered by HAMAP; MF_01230 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier DHMA
Protein name RecName: Full=Haloalkane dehalogenase;
Gene name Name=dhmA;

Comments [?]

FUNCTIONCatalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons.
CATALYTIC ACTIVITY Reaction=1-haloalkane + H2O = a halide anion + a primary alcohol + H(+); Xref=Rhea:RHEA:19081, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15734, ChEBI:CHEBI:16042, ChEBI:CHEBI:18060; EC=;
SIMILARITYBelongs to the haloalkane dehalogenase family. Type 1 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0018786; Molecular function:haloalkane dehalogenase activity

Cross-references [?]

Pfam PF00561; Abhydrolase_1; 1;

Features [?]

From: DHLA_XANAU (P22643)
Key From To Description Tag Condition FTGroup
ACT_SITE 124 124 /note="Nucleophile" D
ACT_SITE 260 260 /note="Proton donor" D
ACT_SITE 289 289 /note="Proton acceptor" H

Additional information [?]

Size range 286-310 amino acids
Related rules MF_01231
Fusion Nter: None Cter: None
Comments We divided the haloalkane dehalogenase family into two subfamilies. Each of which contains a catalytic triad with a different topological arrangement and different amino acids. Moreover, subfamily 1 seems to have a preference for short-chain haloalkanes as substrates, whereas subfamily 2 seems to prefer long-chains.

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