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| Annotation rule MF_01230 |
General rule information
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| Accession | MF_01230 |
| Dates | 5-FEB-2003 (Created) 19-NOV-2019 (Last updated, Version 17) |
| Name | Haloalk_dehal_type1 |
| Scope | Bacteria |
| Templates | P22643 (DHLA_XANAU); Q93K00 (DHMA_MYCAV): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons. |
| Catalytic activity | RHEA:19081: 1-haloalkane + H2O = a halide anion + a primary alcohol + H(+)
EC 3.8.1.5 |
| Subunit | Monomer. |
| Similarity | Belongs to the haloalkane dehalogenase family. Type 1 subfamily. |
Keywords
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Gene Ontology
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GO:0018786; Molecular function: haloalkane dehalogenase activity.
Cross-references
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Features
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| From: DHLA_XANAU (P22643) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 124 | 124 | Nucleophile | D | ||||||||
| ACT_SITE | 260 | 260 | Proton donor | D | ||||||||
| ACT_SITE | 289 | 289 | Proton acceptor | H | ||||||||
Additional information
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| Size range | 286-310 amino acids |
| Related rules | MF_01231 (DHAA) |
| Fusion | None |
| Comments | We divided the haloalkane dehalogenase family into two subfamilies. Each of which contains a catalytic triad with a different topological arrangement and different amino acids. Moreover, subfamily 1 seems to have a preference for short-chain haloalkanes as substrates, whereas subfamily 2 seems to prefer long-chains. |