HAMAP rule MF_01230
General rule information
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Accession |
MF_01230 |
Dates |
5-FEB-2003 (Created) 19-NOV-2019 (Last updated, Version 17) |
Propagated annotation
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Identifier, protein and gene names
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Protein name |
RecName:
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Full=Haloalkane dehalogenase;
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EC 3.8.1.5;
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Function |
Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons. |
Catalytic activity |
RHEA:19081: 1-haloalkane + H2O = a halide anion + a primary alcohol + H(+)
EC 3.8.1.5
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Subunit |
Monomer. |
Similarity |
Belongs to the haloalkane dehalogenase family. Type 1 subfamily. |
GO:0018786; Molecular function: haloalkane dehalogenase activity.
From: DHLA_XANAU (P22643) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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ACT_SITE
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124
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124
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Nucleophile
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D
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ACT_SITE
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260
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260
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Proton donor
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D
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ACT_SITE
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289
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289
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Proton acceptor
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H
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Additional information
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Size range |
286-310 amino acids |
Related rules |
MF_01231 (DHAA) |
Fusion |
None |
Comments |
We divided the haloalkane dehalogenase family into two subfamilies. Each of which contains a catalytic triad with a different topological arrangement and different amino acids. Moreover, subfamily 1 seems to have a preference for short-chain haloalkanes as substrates, whereas subfamily 2 seems to prefer long-chains. |