Home  |  Contact
Annotation rule MF_01230
Send feedback

General rule information [?]

Accession MF_01230
Dates 5-FEB-2003 (Created)
19-NOV-2019 (Last updated, Version 17)
Name Haloalk_dehal_type1
Scope
Bacteria
Templates P22643 (DHLA_XANAU); Q93K00 (DHMA_MYCAV): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
DHMA
Protein name
RecName: Full=Haloalkane dehalogenase;
EC 3.8.1.5;
Gene name
dhmA

Comments [?]

Function Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons.
Catalytic activity RHEA:19081: 1-haloalkane + H2O = a halide anion + a primary alcohol + H(+)
EC 3.8.1.5
Subunit Monomer.
Similarity Belongs to the haloalkane dehalogenase family. Type 1 subfamily.

Keywords [?]


Gene Ontology [?]

GO:0018786; Molecular function: haloalkane dehalogenase activity.

Cross-references [?]

Pfam PF00561; Abhydrolase_1; 1;
PRINTS PR00412; EPOXHYDRLASE; 1;

Features [?]

From: DHLA_XANAU (P22643)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     124     124       Nucleophile     D  
ACT_SITE     260     260       Proton donor     D  
ACT_SITE     289     289       Proton acceptor     H  

Additional information [?]

Size range 286-310 amino acids
Related rules MF_01231 (DHAA)
Fusion None
Comments We divided the haloalkane dehalogenase family into two subfamilies. Each of which contains a catalytic triad with a different topological arrangement and different amino acids. Moreover, subfamily 1 seems to have a preference for short-chain haloalkanes as substrates, whereas subfamily 2 seems to prefer long-chains.