HAMAP rule MF_01230
General rule information
[?]
| PURL | https://purl.expasy.org/hamap/rule/MF_01230 |
| Accession | MF_01230 |
| Dates | 28-FEB-2005 (Created)
19-NOV-2019 (Last updated, Version 13) |
| Name | Haloalk_dehal_type1 |
| Scope(s) |
Bacteria |
| Template(s) | P22643; Q93K00; [ Recover all ] |
| Triggered by |
HAMAP; MF_01230 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | DHMA |
| Protein name | RecName: Full=Haloalkane dehalogenase; EC=3.8.1.5; |
| Gene name | Name=dhmA; |
Comments
[?]
| FUNCTION | Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons. |
| CATALYTIC ACTIVITY | Reaction=1-haloalkane + H2O = a halide anion + a primary alcohol + H(+); Xref=Rhea:RHEA:19081, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15734, ChEBI:CHEBI:16042, ChEBI:CHEBI:18060; EC=3.8.1.5; |
| SUBUNIT | Monomer. |
| SIMILARITY | Belongs to the haloalkane dehalogenase family. Type 1 subfamily. |
Keywords
[?]
Gene Ontology
[?]
| GO:0018786; Molecular function:haloalkane dehalogenase activity |
Cross-references
[?]
Features
[?]
| From: DHLA_XANAU (P22643) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 124 | 124 | /note="Nucleophile" | D | ||||||||
| ACT_SITE | 260 | 260 | /note="Proton donor" | D | ||||||||
| ACT_SITE | 289 | 289 | /note="Proton acceptor" | H | ||||||||
Additional information
[?]
| Size range | 286-310 amino acids |
| Related rules |
MF_01231 |
| Fusion | Nter: None Cter: None |
| Comments | We divided the haloalkane dehalogenase family into two subfamilies. Each of which contains a catalytic triad with a different topological arrangement and different amino acids. Moreover, subfamily 1 seems to have a preference for short-chain haloalkanes as substrates, whereas subfamily 2 seems to prefer long-chains. |