HAMAP rule MF_01231
General rule information
[?]
| Accession |
MF_01231 |
| Dates |
5-FEB-2003 (Created)
17-JAN-2023 (Last updated, Version 23) |
Propagated annotation
[?]
Identifier, protein and gene names
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| Protein name |
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RecName:
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Full=Haloalkane dehalogenase;
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EC 3.8.1.5;
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| Function |
Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons. |
| Catalytic activity |
RHEA:19081: 1-haloalkane + H2O = a halide anion + a primary alcohol + H(+)
EC 3.8.1.5
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| Subunit |
Monomer. |
| Similarity |
Belongs to the haloalkane dehalogenase family. Type 2 subfamily. |
GO:0018786; Molecular function: haloalkane dehalogenase activity.
| From: LINB_SPHIU (D4Z2G1) |
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Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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ACT_SITE
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108
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108
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Nucleophile
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D
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ACT_SITE
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132
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132
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Proton donor
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E
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ACT_SITE
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272
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272
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Proton acceptor
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H
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Additional information
[?]
| Size range |
293-310 amino acids |
| Related rules |
MF_01230 (DHMA) |
| Fusion |
None |
| Comments |
We divided the haloalkane dehalogenase family into two subfamilies. Each of which contains a catalytic triad with a different topological arrangement and different amino acids. Moreover, subfamily 1 seems to have a preference for short-chain haloalkanes as substrates, whereas subfamily 2 seems to prefer long-chains. |
