HAMAP rule MF_01231
General rule information
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| Accession | MF_01231 |
| Dates | 5-FEB-2003 (Created)
17-JAN-2023 (Last updated, Version 23) |
| Name | Haloalk_dehal_type2 |
| Scope(s) |
Bacteria |
| Template(s) | D4Z2G1 (LINB_SPHIU); P59336 (DHAA_RHOSD); Q9ZER0 (DHAA_MYCSX); P0A3G4 (DHAA_PSEPV); P0A3G2 (DHAA_RHORH); P0A3G3 (DHAA_RHOSO); [ Recover all ] |
| Triggered by |
HAMAP; MF_01231 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | DHAA |
| Protein name | RecName: Full=Haloalkane dehalogenase; EC=3.8.1.5; |
| Gene name | Name=dhaA; |
Comments
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| FUNCTION | Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons. |
| CATALYTIC ACTIVITY | Reaction=1-haloalkane + H2O = a halide anion + a primary alcohol + H(+); Xref=Rhea:RHEA:19081, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15734, ChEBI:CHEBI:16042, ChEBI:CHEBI:18060; EC=3.8.1.5; |
| SUBUNIT | Monomer. |
| SIMILARITY | Belongs to the haloalkane dehalogenase family. Type 2 subfamily. |
Keywords
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Gene Ontology
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| GO:0018786; Molecular function:haloalkane dehalogenase activity |
Cross-references
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Features
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| From: LINB_SPHIU (D4Z2G1) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 108 | 108 | /note="Nucleophile" | D | ||||||||
| ACT_SITE | 132 | 132 | /note="Proton donor" | E | ||||||||
| ACT_SITE | 272 | 272 | /note="Proton acceptor" | H | ||||||||
Additional information
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| Size range | 293-310 amino acids |
| Related rules |
MF_01230 |
| Fusion | Nter: None Cter: None |
| Comments | We divided the haloalkane dehalogenase family into two subfamilies. Each of which contains a catalytic triad with a different topological arrangement and different amino acids. Moreover, subfamily 1 seems to have a preference for short-chain haloalkanes as substrates, whereas subfamily 2 seems to prefer long-chains. |