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Annotation rule MF_01231
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General rule information [?]

Accession MF_01231
Dates 5-FEB-2003 (Created)
19-NOV-2019 (Last updated, Version 22)
Name Haloalk_dehal_type2
Scope
Bacteria
Templates D4Z2G1 (LINB_SPHJU); P59336 (DHAA_RHOSD); Q9ZER0 (DHAA_MYCSX); P0A3G4 (DHAA_PSEPV); P0A3G2 (DHAA_RHORH); P0A3G3 (DHAA_RHOSO): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
DHAA
Protein name
RecName: Full=Haloalkane dehalogenase;
EC 3.8.1.5;
Gene name
dhaA

Comments [?]

Function Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons.
Catalytic activity RHEA:19081: 1-haloalkane + H2O = a halide anion + a primary alcohol + H(+)
EC 3.8.1.5
Subunit Monomer.
Similarity Belongs to the haloalkane dehalogenase family. Type 2 subfamily.

Keywords [?]

Hydrolase

Gene Ontology [?]

GO:0018786; Molecular function: haloalkane dehalogenase activity.

Cross-references [?]

Pfam PF00561; Abhydrolase_1; 1;
PRINTS PR00412; EPOXHYDRLASE; 1;

Features [?]

From: LINB_SPHJU (D4Z2G1)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     108     108       Nucleophile     D  
ACT_SITE     132     132       Proton donor     E  
ACT_SITE     272     272       Proton acceptor     H  

Additional information [?]

Size range 293-310 amino acids
Related rules MF_01230 (DHMA)
Fusion None
Comments We divided the haloalkane dehalogenase family into two subfamilies. Each of which contains a catalytic triad with a different topological arrangement and different amino acids. Moreover, subfamily 1 seems to have a preference for short-chain haloalkanes as substrates, whereas subfamily 2 seems to prefer long-chains.


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