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Annotation rule MF_01231 |
Accession | MF_01231 |
Dates | 5-FEB-2003 (Created) 19-NOV-2019 (Last updated, Version 22) |
Name | Haloalk_dehal_type2 |
Scope | Bacteria |
Templates | D4Z2G1 (LINB_SPHJU); P59336 (DHAA_RHOSD); Q9ZER0 (DHAA_MYCSX); P0A3G4 (DHAA_PSEPV); P0A3G2 (DHAA_RHORH); P0A3G3 (DHAA_RHOSO): [Recover all] |
Triggered by |
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Function | Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons. |
Catalytic activity | RHEA:19081: 1-haloalkane + H2O = a halide anion + a primary alcohol + H(+)
EC 3.8.1.5 |
Subunit | Monomer. |
Similarity | Belongs to the haloalkane dehalogenase family. Type 2 subfamily. |
From: LINB_SPHJU (D4Z2G1) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 108 | 108 | Nucleophile | D | ||||||||
ACT_SITE | 132 | 132 | Proton donor | E | ||||||||
ACT_SITE | 272 | 272 | Proton acceptor | H |
Size range | 293-310 amino acids |
Related rules | MF_01230 (DHMA) |
Fusion | None |
Comments | We divided the haloalkane dehalogenase family into two subfamilies. Each of which contains a catalytic triad with a different topological arrangement and different amino acids. Moreover, subfamily 1 seems to have a preference for short-chain haloalkanes as substrates, whereas subfamily 2 seems to prefer long-chains. |