HAMAP logo

HAMAP rule MF_01231

Send feedback

General rule information [?]

Accession MF_01231
Dates 5-FEB-2003 (Created)
17-JAN-2023 (Last updated, Version 23)
Name Haloalk_dehal_type2
Scope(s) Bacteria
Template(s) D4Z2G1 (LINB_SPHIU); P59336 (DHAA_RHOSD); Q9ZER0 (DHAA_MYCSX); P0A3G4 (DHAA_PSEPV); P0A3G2 (DHAA_RHORH); P0A3G3 (DHAA_RHOSO); [ Recover all ]
Triggered by HAMAP; MF_01231 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier DHAA
Protein name RecName: Full=Haloalkane dehalogenase;
Gene name Name=dhaA;

Comments [?]

FUNCTIONCatalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons.
CATALYTIC ACTIVITY Reaction=1-haloalkane + H2O = a halide anion + a primary alcohol + H(+); Xref=Rhea:RHEA:19081, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15734, ChEBI:CHEBI:16042, ChEBI:CHEBI:18060; EC=;
SIMILARITYBelongs to the haloalkane dehalogenase family. Type 2 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0018786; Molecular function:haloalkane dehalogenase activity

Cross-references [?]

Pfam PF00561; Abhydrolase_1; 1;

Features [?]

Key From To Description Tag Condition FTGroup
ACT_SITE 108 108 /note="Nucleophile" D
ACT_SITE 132 132 /note="Proton donor" E
ACT_SITE 272 272 /note="Proton acceptor" H

Additional information [?]

Size range 293-310 amino acids
Related rules MF_01230
Fusion Nter: None Cter: None
Comments We divided the haloalkane dehalogenase family into two subfamilies. Each of which contains a catalytic triad with a different topological arrangement and different amino acids. Moreover, subfamily 1 seems to have a preference for short-chain haloalkanes as substrates, whereas subfamily 2 seems to prefer long-chains.

View rule in raw text format (no links)