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Annotation rule MF_01241 |
General rule information
[?]
Accession |
MF_01241 |
Dates |
21-MAY-2003 (Created) 19-NOV-2019 (Last updated, Version 25) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Protein name |
RecName:
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Full=Glucosamine-6-phosphate deaminase;
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EC 3.5.99.6;
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AltName:
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Full=GlcN6P deaminase;
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Short=GNPDA;
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AltName:
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Full=Glucosamine-6-phosphate isomerase;
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Function |
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. |
Catalytic activity |
RHEA:12172: alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)
EC 3.5.99.6
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case <FTGroup:1>
Activity regulation |
Allosterically activated by N-acetylglucosamine 6-phosphate (GlcNAc6P). |
end case
Pathway |
Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 5/5. |
case <OC:Gammaproteobacteria> and <FT:10>
Subunit |
Homohexamer; trimer of disulfide-linked dimers. |
end case
case <OC:Gammaproteobacteria> and not <FT:10>
end case
Similarity |
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily. |
case <FT:10>
end case
case <FTGroup:1>
end case
GO:0004342; Molecular function: glucosamine-6-phosphate deaminase activity.
GO:0006044; Biological process: N-acetylglucosamine metabolic process.
From: NAGB_ECOLI (P0A759) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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ACT_SITE
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72
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72
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Proton acceptor; for enolization step
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D
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ACT_SITE
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141
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141
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For ring-opening step
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[DN]
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ACT_SITE
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143
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143
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Proton acceptor; for ring-opening step
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H
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ACT_SITE
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148
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148
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For ring-opening step
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E
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SITE (Optional)
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151
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151
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Part of the allosteric site
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S
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1
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SITE (Optional)
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158
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158
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Part of the allosteric site
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R
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1
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SITE (Optional)
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160
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160
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Part of the allosteric site
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K
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1
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SITE (Optional)
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161
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161
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Part of the allosteric site
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T
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1
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SITE (Optional)
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254
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254
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Part of the allosteric site
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Y
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1
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DISULFID (Optional)
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219
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219
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Interchain
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C
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Additional information
[?]
Size range |
233-274 amino acids |
Related rules |
None |
Fusion |
Nter: None; Cter: <Unknown> |
Comments |
Possible second divergent copy in BACTN, which is fused with an unknown C-terminal domain; sequence not included in alignment |