HAMAP rule MF_01241

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_01241
Accession	MF_01241
Dates	28-FEB-2005 (Created) 12-MAR-2024 (Last updated, Version 23)
Name	GlcN6P_deamin
Scope(s)	Bacteria
Template(s)	P0A759; P59686; [ Recover all ]
Triggered by	HAMAP; MF_01241 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	NAGB
Protein name	RecName: Full=Glucosamine-6-phosphate deaminase; EC=3.5.99.6; AltName: Full=GlcN6P deaminase; Short=GNPDA; AltName: Full=Glucosamine-6-phosphate isomerase;
Gene name	Name=nagB;

Comments [?]

FUNCTION	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
CATALYTIC ACTIVITY	Reaction=alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6- phosphate + NH4(+); Xref=Rhea:RHEA:12172, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:57634, ChEBI:CHEBI:75989; EC=3.5.99.6;
case <FTGroup:1>
ACTIVITY REGULATION	Allosterically activated by N-acetylglucosamine 6- phosphate (GlcNAc6P).
end case
PATHWAY	Amino-sugar metabolism; N-acetylneuraminate degradation; D- fructose 6-phosphate from N-acetylneuraminate: step 5/5.
case <OC:Gammaproteobacteria> and <FT:10>
SUBUNIT	Homohexamer; trimer of disulfide-linked dimers.
end case
case <OC:Gammaproteobacteria> and not <FT:10>
SUBUNIT	Homohexamer.
end case
SIMILARITY	Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.

Keywords [?]

Gene Ontology [?]

GO:0004342; Molecular function:glucosamine-6-phosphate deaminase activity

GO:0019262; Biological process:N-acetylneuraminate catabolic process

Cross-references [?]

Features [?]

From: NAGB_ECOLI (P0A759)

Key

From

Description

Tag

Condition

FTGroup

ACT_SITE

/note="Proton acceptor; for enolization step"

ACT_SITE

141

/note="For ring-opening step"

[DN]

ACT_SITE

143

/note="Proton acceptor; for ring-opening step"

ACT_SITE

148

/note="For ring-opening step"

SITE

151