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Annotation rule MF_01241
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General rule information [?]

Accession MF_01241
Dates 21-MAY-2003 (Created)
19-NOV-2019 (Last updated, Version 25)
Name GlcN6P_deamin
Scope
Bacteria
Templates P0A759 (NAGB_ECOLI); P59686 (NAGB_LYSSH): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
NAGB
Protein name
RecName: Full=Glucosamine-6-phosphate deaminase;
EC 3.5.99.6;
AltName: Full=GlcN6P deaminase;
Short=GNPDA;
AltName: Full=Glucosamine-6-phosphate isomerase;
Gene name
nagB

Comments [?]

Function Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
Catalytic activity RHEA:12172: alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)
EC 3.5.99.6
case <FTGroup:1>
Activity regulation Allosterically activated by N-acetylglucosamine 6-phosphate (GlcNAc6P).
end case
Pathway Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 5/5.
case <OC:Gammaproteobacteria> and <FT:10>
Subunit Homohexamer; trimer of disulfide-linked dimers.
end case
case <OC:Gammaproteobacteria> and not <FT:10>
Subunit Homohexamer.
end case
Similarity Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.

Keywords [?]

case <FT:10>
end case
case <FTGroup:1>
end case

Gene Ontology [?]

GO:0004342; Molecular function: glucosamine-6-phosphate deaminase activity.
GO:0006044; Biological process: N-acetylglucosamine metabolic process.

Cross-references [?]

Pfam PF01182; Glucosamine_iso; 1;
TIGRFAMs TIGR00502; NagB; 1;
PROSITE PS01161; GLC_GALNAC_ISOMERASE; 1;

Features [?]

From: NAGB_ECOLI (P0A759)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     72     72       Proton acceptor; for enolization step     D  
ACT_SITE     141     141       For ring-opening step     [DN]  
ACT_SITE     143     143       Proton acceptor; for ring-opening step     H  
ACT_SITE     148     148       For ring-opening step     E  
SITE (Optional)     151     151       Part of the allosteric site     S   1
SITE (Optional)     158     158       Part of the allosteric site     R   1
SITE (Optional)     160     160       Part of the allosteric site     K   1
SITE (Optional)     161     161       Part of the allosteric site     T   1
SITE (Optional)     254     254       Part of the allosteric site     Y   1
DISULFID (Optional)     219     219       Interchain     C  

Additional information [?]

Size range 233-274 amino acids
Related rules None
Fusion Nter: None; Cter: <Unknown>
Comments Possible second divergent copy in BACTN, which is fused with an unknown C-terminal domain; sequence not included in alignment