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HAMAP rule MF_01241

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General rule information [?]

Accession MF_01241
Dates 21-MAY-2003 (Created)
1-JUN-2023 (Last updated, Version 26)
Name GlcN6P_deamin
Scope(s) Bacteria
Template(s) P0A759 (NAGB_ECOLI); P59686 (NAGB_LYSSH); [ Recover all ]
Triggered by HAMAP; MF_01241 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier NAGB
Protein name RecName: Full=Glucosamine-6-phosphate deaminase;
AltName: Full=GlcN6P deaminase;
AltName: Full=Glucosamine-6-phosphate isomerase;
Gene name Name=nagB;

Comments [?]

FUNCTIONCatalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
CATALYTIC ACTIVITY Reaction=alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6- phosphate + NH4(+); Xref=Rhea:RHEA:12172, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:57634, ChEBI:CHEBI:75989; EC=;
case <FTGroup:1>
ACTIVITY REGULATIONAllosterically activated by N-acetylglucosamine 6- phosphate (GlcNAc6P).
end case
PATHWAYAmino-sugar metabolism; N-acetylneuraminate degradation; D- fructose 6-phosphate from N-acetylneuraminate: step 5/5.
case <OC:Gammaproteobacteria> and <FT:10>
SUBUNITHomohexamer; trimer of disulfide-linked dimers.
end case
case <OC:Gammaproteobacteria> and not <FT:10>
end case
SIMILARITYBelongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.

Keywords [?]

Carbohydrate metabolism
case <FT:10>
Disulfide bond
end case
case <FTGroup:1>
Allosteric enzyme
end case

Gene Ontology [?]

GO:0004342; Molecular function:glucosamine-6-phosphate deaminase activity
GO:0006044; Biological process:N-acetylglucosamine metabolic process

Cross-references [?]

Pfam PF01182; Glucosamine_iso; 1;
NCBIfam TIGR00502; NagB; 1;

Features [?]

From: NAGB_ECOLI (P0A759)
Key From To Description Tag Condition FTGroup
ACT_SITE 72 72 /note="Proton acceptor; for enolization step" D
ACT_SITE 141 141 /note="For ring-opening step" [DN]
ACT_SITE 143 143 /note="Proton acceptor; for ring-opening step" H
ACT_SITE 148 148 /note="For ring-opening step" E
SITE 151 151 /note="Part of the allosteric site" S 1
SITE 158 158 /note="Part of the allosteric site" R 1
SITE 160 160 /note="Part of the allosteric site" K 1
SITE 161 161 /note="Part of the allosteric site" T 1
SITE 254 254 /note="Part of the allosteric site" Y 1
DISULFID 219 219 /note="Interchain" C

Additional information [?]

Size range 233-274 amino acids
Related rules None
Fusion Nter: None Cter: <Unknown>
Comments Possible second divergent copy in BACTN, which is fused with an unknown C-terminal domain; sequence not included in alignment

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