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HAMAP rule MF_01242

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General rule information [?]

Accession MF_01242
Dates 23-MAY-2003 (Created)
19-NOV-2019 (Last updated, Version 18)
Name Aliphatic_amidase
Scope(s) Bacteria
Template(s) Q9L543 (AMIE_BACSP); Q9RQ17 (AMIE_GEOSE); O25067 (AMIE_HELPY); P11436 (AMIE_PSEAE); Q01360 (AMIE_RHOER); [ Recover all ]
Triggered by HAMAP; MF_01242 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier AMIE
Protein name RecName: Full=Aliphatic amidase;
AltName: Full=Acylamide amidohydrolase;
Gene name Name=amiE;

Comments [?]

FUNCTIONCatalyzes the hydrolysis of short-chain aliphatic amides to their corresponding organic acids with release of ammonia.
FUNCTIONAlso exhibits in vitro acyl transferase activity, transferring the acyl moiety of short-chain amides to hydroxylamine to form hydroxamates.
CATALYTIC ACTIVITY Reaction=a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+); Xref=Rhea:RHEA:12020, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:35757, ChEBI:CHEBI:83628; EC=;
SIMILARITYBelongs to the carbon-nitrogen hydrolase superfamily. Aliphatic amidase family.

Keywords [?]

Gene Ontology [?]

GO:0004040; Molecular function:amidase activity

Cross-references [?]

Pfam PF00795; CN_hydrolase; 1;

Features [?]

From: AMIE_PSEAE (P11436)
Key From To Description Tag Condition FTGroup
ACT_SITE 59 59 /note="Proton acceptor" E
ACT_SITE 134 134 /note="Proton donor" K
ACT_SITE 166 166 /note="Nucleophile" C

Additional information [?]

Size range 339-348 amino acids
Related rules MF_01243
Fusion Nter: None Cter: None

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