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HAMAP rule MF_01246

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General rule information [?]

Accession MF_01246
Dates 19-JUN-2003 (Created)
19-NOV-2022 (Last updated, Version 28)
Name COD
Scope
Bacteria
Templates P37794 (CHBG_ECOLI); P59745 (YDJC_ENTFA): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

case <OC:Enterobacterales>
Identifier
CHBG
Protein name
RecName: Full=Chitooligosaccharide deacetylase;
Short=COD;
EC 3.5.1.105;
AltName: Full=Chitin disaccharide deacetylase;
AltName: Full=Chitobiose deacetylase;
AltName: Full=Chitobiose-6P deacetylase;
AltName: Full=Chitotriose deacetylase;
AltName: Full=Chitotriose-6P deacetylase;
Gene name
chbG
else
Identifier
YDJC
Protein name
RecName: Full=Carbohydrate deacetylase;
EC 3.5.1.-;
end case

Comments [?]

case <OC:Enterobacterales>
Function Involved in the degradation of chitin. ChbG is essential for growth on the acetylated chitooligosaccharides chitobiose and chitotriose but is dispensable for growth on cellobiose and chitosan dimer, the deacetylated form of chitobiose. Deacetylation of chitobiose-6-P and chitotriose-6-P is necessary for both the activation of the chb promoter by the regulatory protein ChbR and the hydrolysis of phosphorylated beta-glucosides by the phospho-beta-glucosidase ChbF. Catalyzes the removal of only one acetyl group from chitobiose-6-P to yield monoacetylchitobiose-6-P, the inducer of ChbR and the substrate of ChbF.
Catalytic activity RHEA:27469: H2O + N,N'-diacetylchitobiose = acetate + N-acetyl-beta-D-glucosaminyl-(1->4)-D-glucosamine
EC 3.5.1.105
RHEA:35083: diacetylchitobiose-6'-phosphate + H2O = acetate + N'-monoacetylchitobiose-6'-phosphate
Cofactor Mg(2+)
Pathway Glycan degradation; chitin degradation.
Subunit Homodimer.
Subcellular location Cytoplasm.
Similarity Belongs to the YdjC deacetylase family. ChbG subfamily.
else
Function Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.
Cofactor Mg(2+)
Subunit Homodimer.
Similarity Belongs to the YdjC deacetylase family.
end case

Keywords [?]

Carbohydrate metabolism
case <OC:Enterobacterales>
Chitin degradation
Cytoplasm
Polysaccharide degradation
end case
Hydrolase
Magnesium
Metal-binding

Gene Ontology [?]

case <OC:Enterobacterales>
GO:0036311; Molecular function: chitin disaccharide deacetylase activity.
GO:0052777; Biological process: diacetylchitobiose catabolic process.
GO:0005737; Cellular component: cytoplasm.
GO:0000272; Biological process: polysaccharide catabolic process.
end case
GO:0016811; Molecular function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides.

Cross-references [?]

Pfam PF04794; YdjC; 1;

Features [?]

From: CHBG_ECOLI (P37794)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     61     61       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     H  
BINDING     125     125       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     H  

Additional information [?]

Size range 230-262 amino acids
Related rules None
Fusion None


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