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HAMAP rule MF_01254
General rule information
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| Accession | MF_01254 |
| Dates | 16-DEC-2004 (Created)
1-JUN-2023 (Last updated, Version 27) |
| Name | Fucose_iso |
| Scope(s) |
Bacteria |
| Template(s) | P69922 (FUCI_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01254 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | FUCI |
| Protein name | RecName: Full=L-fucose isomerase; Short=FucIase; EC=5.3.1.25; AltName: Full=6-deoxy-L-galactose isomerase; |
| Gene name | Name=fucI; |
Comments
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| FUNCTION | Converts the aldose L-fucose into the corresponding ketose L- fuculose. |
| CATALYTIC ACTIVITY | Reaction=L-fucose = L-fuculose; Xref=Rhea:RHEA:17233, ChEBI:CHEBI:2181, ChEBI:CHEBI:17617; EC=5.3.1.25; |
| COFACTOR | Name=Mn(2+); Xref=ChEBI:CHEBI:29035; |
| PATHWAY | Carbohydrate degradation; L-fucose degradation; L-lactaldehyde and glycerone phosphate from L-fucose: step 1/3. |
| case <OC:Enterobacterales> | |
| SUBUNIT | Homohexamer. |
| end case | |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the L-fucose isomerase family. |
Keywords
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| Cytoplasm | |
| Carbohydrate metabolism | |
| Fucose metabolism | |
| Isomerase | |
| case <FT:3> and <FT:4> and <FT:5> | |
| Manganese | |
| Metal-binding | |
| end case | |
Gene Ontology
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| GO:0008736; Molecular function:L-fucose isomerase activity | |
| case <FT:3> and <FT:4> and <FT:5> | |
| GO:0030145; Molecular function:manganese ion binding | |
| end case | |
| GO:0042355; Biological process:L-fucose catabolic process | |
| GO:0005737; Cellular component:cytoplasm | |
Cross-references
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Features
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| From: FUCI_ECOLI (P69922) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 337 | 337 | /note="Proton acceptor" | E | ||||||||
| ACT_SITE | 361 | 361 | /note="Proton acceptor" | D | ||||||||
| BINDING | 337 | 337 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" |
E | ||||||||
| BINDING | 361 | 361 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" |
D | ||||||||
| BINDING | 528 | 528 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" |
H | ||||||||
Additional information
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| Size range | 560-620 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |