HAMAP rule MF_01265
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_01265 |
| Accession | MF_01265 |
| Dates | 29-JUL-2005 (Created)
12-JUN-2025 (Last updated, Version 27) |
| Name | NadX |
| Scope(s) |
Bacteria Archaea |
| Template(s) | Q9X1X6; O28440; [ Recover all ] |
| Triggered by |
HAMAP; MF_01265 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | ASPD |
| Protein name | RecName: Full=L-aspartate dehydrogenase; EC=1.4.1.21; |
| Gene name | Name=nadX; |
Comments
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| FUNCTION | Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate. |
| CATALYTIC ACTIVITY | Reaction=L-aspartate + NADP(+) + H2O = oxaloacetate + NH4(+) + NADPH + H(+); Xref=Rhea:RHEA:11784, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16452, ChEBI:CHEBI:28938, ChEBI:CHEBI:29991, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.4.1.21; |
| CATALYTIC ACTIVITY | Reaction=L-aspartate + NAD(+) + H2O = oxaloacetate + NH4(+) + NADH + H(+); Xref=Rhea:RHEA:11788, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16452, ChEBI:CHEBI:28938, ChEBI:CHEBI:29991, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.4.1.21; |
| PATHWAY | Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (dehydrogenase route): step 1/1. |
| MISCELLANEOUS | The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia. |
| SIMILARITY | Belongs to the L-aspartate dehydrogenase family. |
Keywords
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Gene Ontology
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| GO:0016639; Molecular function:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
| GO:0050661; Molecular function:NADP binding |
| GO:0051287; Molecular function:NAD binding |
| GO:0009435; Biological process:NAD+ biosynthetic process |
Cross-references
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| Pfam | PF01958; DUF108; 1; |
| Pfam | PF03447; NAD_binding_3; 1; |
| NCBIfam | TIGR03855; NAD_NadX; 1; |
| PIRSF | PIRSF005227; Asp_dh_NAD_syn; 1; |
Features
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| From: ASPD_THEMA (Q9X1X6) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 193 | 193 | H | |||||||||
| BINDING | 109 | 109 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
A | ||||||||
| BINDING | 164 | 164 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
N | ||||||||
Additional information
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| Size range | 236-280 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |