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HAMAP rule MF_01267

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General rule information [?]

Accession MF_01267
Dates 2-MAY-2006 (Created)
19-NOV-2022 (Last updated, Version 20)
Name UlaD
Scope(s) Bacteria
Enterobacterales
Template(s) P39304 (ULAD_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01267 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ULAD
Protein name RecName: Full=3-keto-L-gulonate-6-phosphate decarboxylase UlaD;
                 EC=4.1.1.85;
AltName: Full=3-dehydro-L-gulonate-6-phosphate decarboxylase;
AltName: Full=KGPDC;
AltName: Full=L-ascorbate utilization protein D;
Gene name Name=ulaD;

Comments [?]

FUNCTIONCatalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. Is involved in the anaerobic L-ascorbate utilization.
CATALYTIC ACTIVITY Reaction=3-dehydro-L-gulonate 6-phosphate + H(+) = CO2 + L-xylulose 5- phosphate; Xref=Rhea:RHEA:14353, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57829, ChEBI:CHEBI:58774; EC=4.1.1.85;
case <FTGroup:1>
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.;
end case
PATHWAYCofactor degradation; L-ascorbate degradation; D-xylulose 5- phosphate from L-ascorbate: step 2/4.
SUBUNITHomodimer.
INDUCTIONInduced by L-ascorbate. Repressed by UlaR.
SIMILARITYBelongs to the HPS/KGPDC family. KGPDC subfamily.

Keywords [?]


Gene Ontology [?]

case <FTGroup:1>
GO:0000287; Molecular function:magnesium ion binding
end case
GO:0016831; Molecular function:carboxy-lyase activity
GO:0019854; Biological process:L-ascorbic acid catabolic process

Cross-references [?]

Pfam PF00215; OMPdecase; 1;

Features [?]

From: ULAD_ECOLI (P39304)
Key From To Description Tag Condition FTGroup
BINDING 33 33 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
E 1
BINDING 62 62 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
D 1
BINDING 11 11 /ligand="substrate" D
BINDING 192 192 /ligand="substrate" R
SITE 64 64 /note="Transition state stabilizer"
SITE 67 67 /note="Transition state stabilizer"

Additional information [?]

Size range 216-216 amino acids
Related rules None
Fusion Nter: None Cter: None



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