HAMAP rule MF_01267
General rule information
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| Accession | MF_01267 |
| Dates | 2-MAY-2006 (Created)
3-SEP-2024 (Last updated, Version 21) |
| Name | UlaD |
| Scope(s) |
Bacteria Enterobacterales |
| Template(s) | P39304 (ULAD_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01267 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | ULAD |
| Protein name | RecName: Full=3-keto-L-gulonate-6-phosphate decarboxylase UlaD; EC=4.1.1.85; AltName: Full=3-dehydro-L-gulonate-6-phosphate decarboxylase; AltName: Full=KGPDC; AltName: Full=L-ascorbate utilization protein D; |
| Gene name | Name=ulaD; |
Comments
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| FUNCTION | Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. Is involved in the anaerobic L-ascorbate utilization. |
| CATALYTIC ACTIVITY | Reaction=3-dehydro-L-gulonate 6-phosphate + H(+) = L-xylulose 5- phosphate + CO2; Xref=Rhea:RHEA:14353, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57829, ChEBI:CHEBI:58774; EC=4.1.1.85; |
| case <FTGroup:1> | |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.; |
| end case | |
| PATHWAY | Cofactor degradation; L-ascorbate degradation; D-xylulose 5- phosphate from L-ascorbate: step 2/4. |
| SUBUNIT | Homodimer. |
| INDUCTION | Induced by L-ascorbate. Repressed by UlaR. |
| SIMILARITY | Belongs to the HPS/KGPDC family. KGPDC subfamily. |
Keywords
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| Carbohydrate metabolism | |
| Decarboxylase | |
| Lyase | |
| case <FTGroup:1> | |
| Magnesium | |
| Metal-binding | |
| end case | |
Gene Ontology
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| case <FTGroup:1> | |
| GO:0000287; Molecular function:magnesium ion binding | |
| end case | |
| GO:0016831; Molecular function:carboxy-lyase activity | |
| GO:0019854; Biological process:L-ascorbic acid catabolic process | |
Cross-references
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| Pfam | PF00215; OMPdecase; 1; |
Features
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| From: ULAD_ECOLI (P39304) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 33 | 33 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
E | 1 | |||||||
| BINDING | 62 | 62 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | 1 | |||||||
| BINDING | 11 | 11 | /ligand="substrate" | D | ||||||||
| BINDING | 192 | 192 | /ligand="substrate" | R | ||||||||
| SITE | 64 | 64 | /note="Transition state stabilizer" | |||||||||
| SITE | 67 | 67 | /note="Transition state stabilizer" | |||||||||
Additional information
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| Size range | 216-216 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |