HAMAP rule MF_01267
General rule information
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Accession | MF_01267 |
Dates | 2-MAY-2006 (Created)
19-NOV-2022 (Last updated, Version 20) |
Name | UlaD |
Scope(s) |
Bacteria Enterobacterales |
Template(s) | P39304 (ULAD_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_01267 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | ULAD |
Protein name | RecName: Full=3-keto-L-gulonate-6-phosphate decarboxylase UlaD; EC=4.1.1.85; AltName: Full=3-dehydro-L-gulonate-6-phosphate decarboxylase; AltName: Full=KGPDC; AltName: Full=L-ascorbate utilization protein D; |
Gene name | Name=ulaD; |
Comments
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FUNCTION | Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. Is involved in the anaerobic L-ascorbate utilization. |
CATALYTIC ACTIVITY | Reaction=3-dehydro-L-gulonate 6-phosphate + H(+) = CO2 + L-xylulose 5- phosphate; Xref=Rhea:RHEA:14353, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57829, ChEBI:CHEBI:58774; EC=4.1.1.85; |
case <FTGroup:1> | |
COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.; |
end case | |
PATHWAY | Cofactor degradation; L-ascorbate degradation; D-xylulose 5- phosphate from L-ascorbate: step 2/4. |
SUBUNIT | Homodimer. |
INDUCTION | Induced by L-ascorbate. Repressed by UlaR. |
SIMILARITY | Belongs to the HPS/KGPDC family. KGPDC subfamily. |
Keywords
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Carbohydrate metabolism | |
Decarboxylase | |
Lyase | |
case <FTGroup:1> | |
Magnesium | |
Metal-binding | |
end case |
Gene Ontology
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case <FTGroup:1> | |
GO:0000287; Molecular function:magnesium ion binding | |
end case | |
GO:0016831; Molecular function:carboxy-lyase activity | |
GO:0019854; Biological process:L-ascorbic acid catabolic process |
Cross-references
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Pfam | PF00215; OMPdecase; 1; |
Features
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From: ULAD_ECOLI (P39304) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 33 | 33 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
E | 1 | |||||||
BINDING | 62 | 62 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | 1 | |||||||
BINDING | 11 | 11 | /ligand="substrate" | D | ||||||||
BINDING | 192 | 192 | /ligand="substrate" | R | ||||||||
SITE | 64 | 64 | /note="Transition state stabilizer" | |||||||||
SITE | 67 | 67 | /note="Transition state stabilizer" |
Additional information
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Size range | 216-216 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |