HAMAP rule MF_01270
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_01270 |
| Accession | MF_01270 |
| Dates | 31-AUG-2006 (Created)
3-SEP-2024 (Last updated, Version 20) |
| Name | AnhMurNAc_kinase |
| Scope(s) |
Bacteria |
| Template(s) | P77570 (ANMK_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01270 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | ANMK |
| Protein name | RecName: Full=Anhydro-N-acetylmuramic acid kinase; EC=2.7.1.170; AltName: Full=AnhMurNAc kinase; |
| Gene name | Name=anmK; |
Comments
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| FUNCTION | Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. |
| CATALYTIC ACTIVITY | Reaction=1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O = N-acetyl-D- muramate 6-phosphate + ADP + H(+); Xref=Rhea:RHEA:24952, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:58690, ChEBI:CHEBI:58722, ChEBI:CHEBI:456216; EC=2.7.1.170; |
| PATHWAY | Amino-sugar metabolism; 1,6-anhydro-N-acetylmuramate degradation. |
| PATHWAY | Cell wall biogenesis; peptidoglycan recycling. |
| SIMILARITY | Belongs to the anhydro-N-acetylmuramic acid kinase family. |
Keywords
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Gene Ontology
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| GO:0005524; Molecular function:ATP binding |
| GO:0016773; Molecular function:phosphotransferase activity, alcohol group as acceptor |
| GO:0097175; Biological process:1,6-anhydro-N-acetyl-beta-muramic acid catabolic process |
| GO:0009254; Biological process:peptidoglycan turnover |
Cross-references
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| Pfam | PF03702; UPF0075; 1; |
Features
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| From: ANMK_ECOLI (P77570) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 12 | 19 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
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Additional information
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| Size range | 355-436 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |