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HAMAP rule MF_01274
General rule information
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| Accession | MF_01274 |
| Dates | 21-NOV-2006 (Created)
1-JUN-2023 (Last updated, Version 24) |
| Name | Pantothen_kinase_3 |
| Scope(s) |
Bacteria |
| Template(s) | Q9HWC1 (COAX_PSEAE); P37564 (COAX_BACSU); O25533 (COAX_HELPY); Q9WZY5 (COAX_THEMA); [ Recover all ] |
| Triggered by |
HAMAP; MF_01274 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | COAX |
| Protein name | RecName: Full=Type III pantothenate kinase; EC=2.7.1.33; AltName: Full=PanK-III; AltName: Full=Pantothenic acid kinase; |
| Gene name | Name=coaX; |
Comments
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| FUNCTION | Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. |
| CATALYTIC ACTIVITY | Reaction=(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+); Xref=Rhea:RHEA:16373, ChEBI:CHEBI:10986, ChEBI:CHEBI:15378, ChEBI:CHEBI:29032, ChEBI:CHEBI:30616, ChEBI:CHEBI:456216; EC=2.7.1.33; |
| COFACTOR | Name=NH4(+); Xref=ChEBI:CHEBI:28938; Name=K(+); Xref=ChEBI:CHEBI:29103; Note=A monovalent cation. Ammonium or potassium.; |
| PATHWAY | Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)- pantothenate: step 1/5. |
| SUBUNIT | Homodimer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the type III pantothenate kinase family. |
Keywords
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| Cytoplasm | |
| ATP-binding | |
| Coenzyme A biosynthesis | |
| Kinase | |
| case <FT:4> | |
| Metal-binding | |
| end case | |
| Nucleotide-binding | |
| Transferase | |
| Potassium | |
Gene Ontology
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| GO:0005524; Molecular function:ATP binding | |
| GO:0004594; Molecular function:pantothenate kinase activity | |
| case <FT:4> | |
| GO:0043169; Molecular function:cation binding | |
| end case | |
| GO:0015937; Biological process:coenzyme A biosynthetic process | |
| GO:0005737; Cellular component:cytoplasm | |
Cross-references
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Features
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| From: COAX_PSEAE (Q9HWC1) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 6 | 13 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
|||||||||
| BINDING | 99 | 102 | /ligand="substrate" | G-x-D-x | ||||||||
| ACT_SITE | 101 | 101 | /note="Proton acceptor" | D | ||||||||
| BINDING | 121 | 121 | /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103" |
D | ||||||||
| BINDING | 92 | 92 | /ligand="substrate" | [YF] | ||||||||
| BINDING | 124 | 124 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[TS] | ||||||||
| BINDING | 180 | 180 | /ligand="substrate" | [TS] | ||||||||
Additional information
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| Size range | 205-295 amino acids |
| Related rules |
None |
| Fusion | Nter: <birA> Cter: None |
| Comments | There are three distinct types of pantothenate kinase, as differenciated by primary sequence analysis and biochemical properties: type I (MF_00215), type II (MF_01273) and type III (MF_01274). |