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Annotation rule MF_01274 |
General rule information
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Accession |
MF_01274 |
Dates |
21-NOV-2006 (Created) 19-NOV-2019 (Last updated, Version 19) |
Propagated annotation
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Identifier, protein and gene names
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Protein name |
RecName:
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Full=Type III pantothenate kinase;
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EC 2.7.1.33;
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AltName:
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Full=PanK-III;
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AltName:
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Full=Pantothenic acid kinase;
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Function |
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. |
Catalytic activity |
RHEA:16373: (R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)
EC 2.7.1.33
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Cofactor |
NH4(+) K(+) Note: A monovalent cation. Ammonium or potassium. |
Pathway |
Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. |
Subunit |
Homodimer. |
Subcellular location |
Cytoplasm. |
Similarity |
Belongs to the type III pantothenate kinase family. |
case <FT:4>
end case
GO:0005524; Molecular function: ATP binding.
GO:0004594; Molecular function: pantothenate kinase activity.
case <FT:4>
end case
GO:0015937; Biological process: coenzyme A biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
From: COAX_PSEAE (Q9HWC1) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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NP_BIND
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6
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13
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ATP
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REGION
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99
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102
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Substrate binding
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G-x-D-x
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ACT_SITE
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101
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101
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Proton acceptor
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D
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METAL (Optional)
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121
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121
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Monovalent cation
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D
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BINDING (Optional)
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92
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92
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Substrate
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[YF]
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BINDING
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124
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124
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ATP
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[TS]
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BINDING (Optional)
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180
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180
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Substrate
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[TS]
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Additional information
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Size range |
205-295 amino acids |
Related rules |
None |
Fusion |
Nter: <birA>; Cter: None |
Comments |
There are three distinct types of pantothenate kinase, as differenciated by primary sequence analysis and biochemical properties: type I (MF_00215), type II (MF_01273) and type III (MF_01274). |