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HAMAP rule MF_01274

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General rule information [?]

Accession MF_01274
Dates 21-NOV-2006 (Created)
1-JUN-2023 (Last updated, Version 24)
Name Pantothen_kinase_3
Scope(s) Bacteria
Template(s) Q9HWC1 (COAX_PSEAE); P37564 (COAX_BACSU); O25533 (COAX_HELPY); Q9WZY5 (COAX_THEMA); [ Recover all ]
Triggered by HAMAP; MF_01274 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier COAX
Protein name RecName: Full=Type III pantothenate kinase;
AltName: Full=PanK-III;
AltName: Full=Pantothenic acid kinase;
Gene name Name=coaX;

Comments [?]

FUNCTIONCatalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
CATALYTIC ACTIVITY Reaction=(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+); Xref=Rhea:RHEA:16373, ChEBI:CHEBI:10986, ChEBI:CHEBI:15378, ChEBI:CHEBI:29032, ChEBI:CHEBI:30616, ChEBI:CHEBI:456216; EC=;
COFACTOR Name=NH4(+); Xref=ChEBI:CHEBI:28938; Name=K(+); Xref=ChEBI:CHEBI:29103; Note=A monovalent cation. Ammonium or potassium.;
PATHWAYCofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)- pantothenate: step 1/5.
SIMILARITYBelongs to the type III pantothenate kinase family.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0004594; Molecular function:pantothenate kinase activity
case <FT:4>
GO:0043169; Molecular function:cation binding
end case
GO:0015937; Biological process:coenzyme A biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF03309; Pan_kinase; 1;
NCBIfam TIGR00671; Baf; 1;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 6 13 /ligand="ATP"
BINDING 99 102 /ligand="substrate" G-x-D-x
ACT_SITE 101 101 /note="Proton acceptor" D
BINDING 121 121 /ligand="K(+)"
BINDING 92 92 /ligand="substrate" [YF]
BINDING 124 124 /ligand="ATP"
BINDING 180 180 /ligand="substrate" [TS]

Additional information [?]

Size range 205-295 amino acids
Related rules None
Fusion Nter: <birA> Cter: None
Comments There are three distinct types of pantothenate kinase, as differenciated by primary sequence analysis and biochemical properties: type I (MF_00215), type II (MF_01273) and type III (MF_01274).

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