HAMAP rule MF_01274

General rule information [?]

Accession	MF_01274
Dates	21-NOV-2006 (Created) 1-JUN-2023 (Last updated, Version 24)

Name	Pantothen_kinase_3

Scope

Bacteria

Templates

Q9HWC1 (COAX_PSEAE); P37564 (COAX_BACSU); O25533 (COAX_HELPY); Q9WZY5 (COAX_THEMA): [Recover all]

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

COAX

Protein name

RecName:		Full=Type III pantothenate kinase;
		EC 2.7.1.33;
AltName:		Full=PanK-III;
AltName:		Full=Pantothenic acid kinase;

Gene name

coaX

Comments [?]

Function	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
Catalytic activity	RHEA:16373: (R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+) EC 2.7.1.33
Cofactor	NH4(+) K(+) Note: A monovalent cation. Ammonium or potassium.
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.
Subunit	Homodimer.
Subcellular location	Cytoplasm.
Similarity	Belongs to the type III pantothenate kinase family.

Keywords [?]

case <FT:4>

end case

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0004594; Molecular function: pantothenate kinase activity.

case <FT:4>

GO:0043169; Molecular function: cation binding.

end case

GO:0015937; Biological process: coenzyme A biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF03309; Pan_kinase; 1;
NCBIfam	TIGR00671; Baf; 1;

Features [?]

From: COAX_PSEAE (Q9HWC1)

Key From To Description Tag Condition FTGroup

BINDING 6 13 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616

BINDING 99 102 /ligand="substrate G-x-D-x

ACT_SITE 101 101 Proton acceptor D

BINDING (Optional) 121 121 /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103 D

BINDING (Optional) 92 92 /ligand="substrate [YF]

BINDING 124 124 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 [TS]

BINDING (Optional) 180 180 /ligand="substrate [TS]

Additional information [?]

Size range	205-295 amino acids
Related rules	None
Fusion	Nter: <birA>; Cter: None
Comments	There are three distinct types of pantothenate kinase, as differenciated by primary sequence analysis and biochemical properties: type I (MF_00215), type II (MF_01273) and type III (MF_01274).