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HAMAP rule MF_01274

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General rule information [?]

Accession MF_01274
Dates 21-NOV-2006 (Created)
1-JUN-2023 (Last updated, Version 24)
Name Pantothen_kinase_3
Templates Q9HWC1 (COAX_PSEAE); P37564 (COAX_BACSU); O25533 (COAX_HELPY); Q9WZY5 (COAX_THEMA): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Type III pantothenate kinase;
AltName: Full=PanK-III;
AltName: Full=Pantothenic acid kinase;
Gene name

Comments [?]

Function Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
Catalytic activity RHEA:16373: (R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)
Cofactor NH4(+)
Note: A monovalent cation. Ammonium or potassium.
Pathway Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.
Subunit Homodimer.
Subcellular location Cytoplasm.
Similarity Belongs to the type III pantothenate kinase family.

Keywords [?]

case <FT:4>
end case

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0004594; Molecular function: pantothenate kinase activity.
case <FT:4>
GO:0043169; Molecular function: cation binding.
end case
GO:0015937; Biological process: coenzyme A biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF03309; Pan_kinase; 1;
NCBIfam TIGR00671; Baf; 1;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
BINDING     6     13       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616        
BINDING     99     102       /ligand="substrate     G-x-D-x  
ACT_SITE     101     101       Proton acceptor     D  
BINDING (Optional)     121     121       /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103     D  
BINDING (Optional)     92     92       /ligand="substrate     [YF]  
BINDING     124     124       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     [TS]  
BINDING (Optional)     180     180       /ligand="substrate     [TS]  

Additional information [?]

Size range 205-295 amino acids
Related rules None
Fusion Nter: <birA>; Cter: None
Comments There are three distinct types of pantothenate kinase, as differenciated by primary sequence analysis and biochemical properties: type I (MF_00215), type II (MF_01273) and type III (MF_01274).