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HAMAP rule MF_01275

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General rule information [?]

PURL https://purl.expasy.org/hamap/rule/MF_01275
Accession MF_01275
Dates 29-NOV-2006 (Created)
03-SEP-2024 (Last updated, Version 22)
Name Aldedh_Prr
Scope(s) Bacteria
Enterobacterales
Template(s) P77674; [ Recover all ]
Triggered by HAMAP; MF_01275 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ABDH
Protein name RecName: Full=Gamma-aminobutyraldehyde dehydrogenase;
                 Short=ABALDH;
                 EC=1.2.1.19;
AltName: Full=1-pyrroline dehydrogenase;
AltName: Full=4-aminobutanal dehydrogenase;
AltName: Full=5-aminopentanal dehydrogenase;
                 EC=1.2.1.-;
Gene name Name=patD;

Comments [?]

FUNCTIONCatalyzes the oxidation 4-aminobutanal (gamma- aminobutyraldehyde) to 4-aminobutanoate (gamma-aminobutyrate or GABA). This is the second step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate via 4- aminobutanal. Also functions as a 5-aminopentanal dehydrogenase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
CATALYTIC ACTIVITY Reaction=4-aminobutanal + NAD(+) + H2O = 4-aminobutanoate + NADH + 2 H(+); Xref=Rhea:RHEA:19105, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58264, ChEBI:CHEBI:59888; EC=1.2.1.19; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19106;
CATALYTIC ACTIVITY Reaction=5-aminopentanal + NAD(+) + H2O = 5-aminopentanoate + NADH + 2 H(+); Xref=Rhea:RHEA:61632, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:144896, ChEBI:CHEBI:356010; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61633;
PATHWAYAmine and polyamine degradation; putrescine degradation; 4- aminobutanoate from 4-aminobutanal: step 1/1.
PATHWAYAmino-acid degradation.
SUBUNITHomotetramer.
MISCELLANEOUS4-aminobutanal can spontaneously cyclize to 1-pyrroline, and 5-aminopentanal to 1-piperideine.
SIMILARITYBelongs to the aldehyde dehydrogenase family. Gamma- aminobutyraldehyde dehydrogenase subfamily.

Keywords [?]

NAD
Oxidoreductase

Gene Ontology [?]

GO:0019145; Molecular function:aminobutyraldehyde dehydrogenase (NAD+) activity
GO:0051287; Molecular function:NAD binding
GO:0009447; Biological process:putrescine catabolic process
GO:0019477; Biological process:L-lysine catabolic process

Cross-references [?]

PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1;
PROSITE PS00687; ALDEHYDE_DEHYDR_GLU; 1;
Pfam PF00171; Aldedh; 1;
NCBIfam TIGR03374; ABALDH; 1;

Features [?]

From: ABDH_ECOLI (P77674)
Key From To Description Tag Condition FTGroup
BINDING 146 148 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"		 A-x-W
BINDING 172 175 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"		 K-x-x-E
BINDING 225 228 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"		 S-x-x-T
ACT_SITE 246 246 E
ACT_SITE 280 280 /note="Nucleophile" C
BINDING 209 209 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"		 D
BINDING 280 280 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"		 C

Additional information [?]

Size range 465-485 amino acids
Related rules None
Fusion Nter: None Cter: None



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