HAMAP rule MF_01275

General rule information [?]

Accession	MF_01275
Dates	29-NOV-2006 (Created) 1-JUN-2023 (Last updated, Version 20)

Name	Aldedh_Prr

Scope

Bacteria; Enterobacterales

Template

P77674 (ABDH_ECOLI)

Triggered by

HAMAP; MF_01275 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

ABDH

Protein name

RecName:		Full=Gamma-aminobutyraldehyde dehydrogenase;
		Short=ABALDH;
		EC 1.2.1.19;
AltName:		Full=1-pyrroline dehydrogenase;
AltName:		Full=4-aminobutanal dehydrogenase;
AltName:		Full=5-aminopentanal dehydrogenase;
		EC 1.2.1.-;

Gene name

patD

Comments [?]

Function	Catalyzes the oxidation 4-aminobutanal (gamma-aminobutyraldehyde) to 4-aminobutanoate (gamma-aminobutyrate or GABA). This is the second step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate via 4-aminobutanal. Also functions as a 5-aminopentanal dehydrogenase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
Catalytic activity	RHEA:19105: 4-aminobutanal + H2O + NAD(+) = 4-aminobutanoate + 2 H(+) + NADH EC 1.2.1.19 PhysiologicalDirection=left-to-right (RHEA:19106)
	RHEA:61632: 5-aminopentanal + H2O + NAD(+) = 5-aminopentanoate + 2 H(+) + NADH PhysiologicalDirection=left-to-right (RHEA:61633)
Pathway	Amine and polyamine degradation; putrescine degradation; 4-aminobutanoate from 4-aminobutanal: step 1/1.
	Amino-acid degradation.
Subunit	Homotetramer.
Miscellaneous	4-aminobutanal can spontaneously cyclize to 1-pyrroline, and 5-aminopentanal to 1-piperideine.
Similarity	Belongs to the aldehyde dehydrogenase family. Gamma-aminobutyraldehyde dehydrogenase subfamily.

Keywords [?]

NAD
Oxidoreductase

Gene Ontology [?]

GO:0019145; Molecular function: aminobutyraldehyde dehydrogenase activity.
GO:0051287; Molecular function: NAD binding.
GO:0009447; Biological process: putrescine catabolic process.
GO:0019477; Biological process: L-lysine catabolic process.

Cross-references [?]

PROSITE	PS00070; ALDEHYDE_DEHYDR_CYS; 1;
	PS00687; ALDEHYDE_DEHYDR_GLU; 1;
Pfam	PF00171; Aldedh; 1;
NCBIfam	TIGR03374; ABALDH; 1;

Features [?]

From: ABDH_ECOLI (P77674)

Key From To Description Tag Condition FTGroup

BINDING 146 148 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 A-x-W

BINDING 172 175 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 K-x-x-E

BINDING 225 228 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 S-x-x-T

ACT_SITE 246 246 E

ACT_SITE 280 280 Nucleophile C

BINDING 209 209 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 D

BINDING 280 280 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 C

Additional information [?]

Size range	465-485 amino acids
Related rules	None
Fusion	None

View rule in raw text format (no links)