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Annotation rule MF_01275 |
Accession | MF_01275 |
Dates | 29-NOV-2006 (Created) 19-NOV-2019 (Last updated, Version 17) |
Name | Aldedh_Prr |
Scope | Bacteria; Enterobacterales |
Template | P77674 (ABDH_ECOLI) |
Triggered by |
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Protein name |
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Gene name |
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Function | Catalyzes the oxidation 4-aminobutanal (gamma-aminobutyraldehyde) to 4-aminobutanoate (gamma-aminobutyrate or GABA). This is the second step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate via 4-aminobutanal. Also functions as a 5-aminopentanal dehydrogenase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. |
Catalytic activity | RHEA:19105: 4-aminobutanal + H2O + NAD(+) = 4-aminobutanoate + 2 H(+) + NADH
EC 1.2.1.19 PhysiologicalDirection=left-to-right (RHEA:19106) |
RHEA:61632: 5-aminopentanal + H2O + NAD(+) = 5-aminopentanoate + 2 H(+) + NADH
PhysiologicalDirection=left-to-right (RHEA:61633) |
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Pathway | Amine and polyamine degradation; putrescine degradation; 4-aminobutanoate from 4-aminobutanal: step 1/1. |
Amino-acid degradation. | |
Subunit | Homotetramer. |
Miscellaneous | 4-aminobutanal can spontaneously cyclize to 1-pyrroline, and 5-aminopentanal to 1-piperideine. |
Similarity | Belongs to the aldehyde dehydrogenase family. Gamma-aminobutyraldehyde dehydrogenase subfamily. |
PROSITE | PS00070; ALDEHYDE_DEHYDR_CYS; 1; |
PS00687; ALDEHYDE_DEHYDR_GLU; 1; | |
Pfam | PF00171; Aldedh; 1; |
TIGRFAMs | TIGR03374; ABALDH; 1; |
From: ABDH_ECOLI (P77674) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
NP_BIND | 146 | 148 | NAD | A-x-W | ||||||||
NP_BIND | 172 | 175 | NAD | K-x-x-E | ||||||||
NP_BIND | 225 | 228 | NAD | S-x-x-T | ||||||||
ACT_SITE | 246 | 246 | E | |||||||||
ACT_SITE | 280 | 280 | Nucleophile | C | ||||||||
BINDING | 209 | 209 | NAD | D | ||||||||
BINDING | 280 | 280 | NAD | C |
Size range | 465-485 amino acids |
Related rules | None |
Fusion | None |