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HAMAP rule MF_01275

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General rule information [?]

Accession MF_01275
Dates 29-NOV-2006 (Created)
1-JUN-2023 (Last updated, Version 20)
Name Aldedh_Prr
Scope(s) Bacteria
Template(s) P77674 (ABDH_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01275 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ABDH
Protein name RecName: Full=Gamma-aminobutyraldehyde dehydrogenase;
AltName: Full=1-pyrroline dehydrogenase;
AltName: Full=4-aminobutanal dehydrogenase;
AltName: Full=5-aminopentanal dehydrogenase;
Gene name Name=patD;

Comments [?]

FUNCTIONCatalyzes the oxidation 4-aminobutanal (gamma- aminobutyraldehyde) to 4-aminobutanoate (gamma-aminobutyrate or GABA). This is the second step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate via 4- aminobutanal. Also functions as a 5-aminopentanal dehydrogenase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
CATALYTIC ACTIVITY Reaction=4-aminobutanal + H2O + NAD(+) = 4-aminobutanoate + 2 H(+) + NADH; Xref=Rhea:RHEA:19105, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58264, ChEBI:CHEBI:59888; EC=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19106;
CATALYTIC ACTIVITY Reaction=5-aminopentanal + H2O + NAD(+) = 5-aminopentanoate + 2 H(+) + NADH; Xref=Rhea:RHEA:61632, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:144896, ChEBI:CHEBI:356010; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61633;
PATHWAYAmine and polyamine degradation; putrescine degradation; 4- aminobutanoate from 4-aminobutanal: step 1/1.
PATHWAYAmino-acid degradation.
MISCELLANEOUS4-aminobutanal can spontaneously cyclize to 1-pyrroline, and 5-aminopentanal to 1-piperideine.
SIMILARITYBelongs to the aldehyde dehydrogenase family. Gamma- aminobutyraldehyde dehydrogenase subfamily.

Keywords [?]

Gene Ontology [?]

GO:0019145; Molecular function:aminobutyraldehyde dehydrogenase activity
GO:0051287; Molecular function:NAD binding
GO:0009447; Biological process:putrescine catabolic process
GO:0019477; Biological process:L-lysine catabolic process

Cross-references [?]

Pfam PF00171; Aldedh; 1;
NCBIfam TIGR03374; ABALDH; 1;

Features [?]

From: ABDH_ECOLI (P77674)
Key From To Description Tag Condition FTGroup
BINDING 146 148 /ligand="NAD(+)"
BINDING 172 175 /ligand="NAD(+)"
BINDING 225 228 /ligand="NAD(+)"
ACT_SITE 246 246 E
ACT_SITE 280 280 /note="Nucleophile" C
BINDING 209 209 /ligand="NAD(+)"
BINDING 280 280 /ligand="NAD(+)"

Additional information [?]

Size range 465-485 amino acids
Related rules None
Fusion Nter: None Cter: None

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