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Annotation rule MF_01275
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General rule information [?]

Accession MF_01275
Dates 29-NOV-2006 (Created)
19-NOV-2019 (Last updated, Version 17)
Name Aldedh_Prr
Scope
Bacteria; Enterobacterales
Template P77674 (ABDH_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
ABDH
Protein name
RecName: Full=Gamma-aminobutyraldehyde dehydrogenase;
Short=ABALDH;
EC 1.2.1.19;
AltName: Full=1-pyrroline dehydrogenase;
AltName: Full=4-aminobutanal dehydrogenase;
AltName: Full=5-aminopentanal dehydrogenase;
EC 1.2.1.-;
Gene name
patD

Comments [?]

Function Catalyzes the oxidation 4-aminobutanal (gamma-aminobutyraldehyde) to 4-aminobutanoate (gamma-aminobutyrate or GABA). This is the second step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate via 4-aminobutanal. Also functions as a 5-aminopentanal dehydrogenase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
Catalytic activity RHEA:19105: 4-aminobutanal + H2O + NAD(+) = 4-aminobutanoate + 2 H(+) + NADH
EC 1.2.1.19
PhysiologicalDirection=left-to-right (RHEA:19106)
RHEA:61632: 5-aminopentanal + H2O + NAD(+) = 5-aminopentanoate + 2 H(+) + NADH
PhysiologicalDirection=left-to-right (RHEA:61633)
Pathway Amine and polyamine degradation; putrescine degradation; 4-aminobutanoate from 4-aminobutanal: step 1/1.
Amino-acid degradation.
Subunit Homotetramer.
Miscellaneous 4-aminobutanal can spontaneously cyclize to 1-pyrroline, and 5-aminopentanal to 1-piperideine.
Similarity Belongs to the aldehyde dehydrogenase family. Gamma-aminobutyraldehyde dehydrogenase subfamily.

Keywords [?]

NAD
Oxidoreductase

Gene Ontology [?]

GO:0019145; Molecular function: aminobutyraldehyde dehydrogenase activity.
GO:0051287; Molecular function: NAD binding.
GO:0009447; Biological process: putrescine catabolic process.
GO:0019477; Biological process: L-lysine catabolic process.

Cross-references [?]

PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1;
PS00687; ALDEHYDE_DEHYDR_GLU; 1;
Pfam PF00171; Aldedh; 1;
TIGRFAMs TIGR03374; ABALDH; 1;

Features [?]

From: ABDH_ECOLI (P77674)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     146     148       NAD     A-x-W  
NP_BIND     172     175       NAD     K-x-x-E  
NP_BIND     225     228       NAD     S-x-x-T  
ACT_SITE     246     246             E  
ACT_SITE     280     280       Nucleophile     C  
BINDING     209     209       NAD     D  
BINDING     280     280       NAD     C  

Additional information [?]

Size range 465-485 amino acids
Related rules None
Fusion None


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