HAMAP rule MF_01279
General rule information
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Accession | MF_01279 |
Dates | 15-AUG-2007 (Created) 19-NOV-2022 (Last updated, Version 15) |
Name | X_Pro_dipeptid |
Scope | Bacteria; Gammaproteobacteria |
Templates | P21165 (PEPQ_ECOLI); Q44238 (PEPQ_ALTSX); P77814 (PEPQ_PSEHA): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Splits dipeptides with a prolyl residue in the C-terminal position. |
Catalytic activity | Reaction=Hydrolysis of Xaa-|-Pro dipeptides. Also acts on aminoacyl-hydroxyproline analogs. No action on Pro-|-Pro.; EC=3.4.13.9; |
Cofactor | Mn(2+) Note: Binds 2 manganese ions per subunit. |
Similarity | Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily. |
Keywords
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Gene Ontology
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GO:0008235; Molecular function: metalloexopeptidase activity.
GO:0016805; Molecular function: dipeptidase activity.
GO:0016805; Molecular function: dipeptidase activity.
Cross-references
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Features
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From: PEPQ_ECOLI (P21165) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 246 | 246 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2 | D | ||||||||
BINDING | 257 | 257 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1 | D | ||||||||
BINDING | 257 | 257 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2 | D | ||||||||
BINDING | 339 | 339 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1 | H | ||||||||
BINDING | 384 | 384 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1 | E | ||||||||
BINDING | 423 | 423 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1 | E | ||||||||
BINDING | 423 | 423 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2 | E |
Additional information
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Size range | 429-452 amino acids |
Related rules | None |
Fusion | None |
Comments | PepQ from Alteromonas sp. and Pseudoalteromonas haloplanktis was also shown to efficiently catalyze the hydrolysis of toxic organophosphorus cholinesterase-inhibiting compounds including insecticide paraoxon and nerve gases such as O-isopropyl methylphosphonofluoridate (sarin) and O-pinacolyl (soman). |