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Annotation rule MF_01279
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General rule information [?]

Accession MF_01279
Dates 15-AUG-2007 (Created)
19-NOV-2019 (Last updated, Version 13)
Name X_Pro_dipeptid
Scope
Bacteria; Gammaproteobacteria
Templates P21165 (PEPQ_ECOLI); Q44238 (PEPQ_ALTSX); P77814 (PEPQ_PSEHA): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PEPQ
Protein name
RecName: Full=Xaa-Pro dipeptidase;
Short=X-Pro dipeptidase;
EC 3.4.13.9;
AltName: Full=Imidodipeptidase;
AltName: Full=Proline dipeptidase;
Short=Prolidase;
Gene name
pepQ

Comments [?]

Function Splits dipeptides with a prolyl residue in the C-terminal position.
Catalytic activity Reaction=Hydrolysis of Xaa-|-Pro dipeptides. Also acts on aminoacyl-hydroxyproline analogs. No action on Pro-|-Pro.; EC=3.4.13.9;
Cofactor Mn(2+)
Note: Binds 2 manganese ions per subunit.
Similarity Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily.

Keywords [?]


Gene Ontology [?]

GO:0008235; Molecular function: metalloexopeptidase activity.
GO:0016805; Molecular function: dipeptidase activity.

Cross-references [?]

PROSITE PS00491; PROLINE_PEPTIDASE; 1;
Pfam PF00557; Peptidase_M24; 1;

Features [?]

From: PEPQ_ECOLI (P21165)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     246     246       Manganese 2     D  
METAL     257     257       Manganese 1     D  
METAL     257     257       Manganese 2     D  
METAL     339     339       Manganese 1     H  
METAL     384     384       Manganese 1     E  
METAL     423     423       Manganese 1     E  
METAL     423     423       Manganese 2     E  

Additional information [?]

Size range 429-452 amino acids
Related rules None
Fusion None
Comments PepQ from Alteromonas sp. and Pseudoalteromonas haloplanktis was also shown to efficiently catalyze the hydrolysis of toxic organophosphorus cholinesterase-inhibiting compounds including insecticide paraoxon and nerve gases such as O-isopropyl methylphosphonofluoridate (sarin) and O-pinacolyl (soman).