HAMAP rule MF_01288
General rule information
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Accession | MF_01288 |
Dates | 19-SEP-2008 (Created) 26-JAN-2023 (Last updated, Version 14) |
Name | Rhamnon_dehydrat |
Scope | Bacteria; Actinomycetota
Bacteria; Pseudomonadota
Archaea |
Templates | Q8ZNF9 (RHMD_SALTY); P77215 (RHMD_ECOLI); Q12DF1 (RHMD_POLSJ): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
|
case <OC:Bacteria>
Protein name |
|
end case
case <OC:Archaea>
Protein name |
|
end case
Gene name |
|
Comments
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Function | Catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy-L-rhamnonate (KDR). |
Catalytic activity | RHEA:23080: L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H2O
EC 4.2.1.90 |
case <FTGroup:1>
Cofactor | Mg(2+) Note: Binds 1 Mg(2+) ion per subunit. |
end case
case <OC:Pseudomonadota>
Subunit | Homooctamer; tetramer of dimers. |
end case
Miscellaneous | Reaction proceeds via a syn dehydration. |
Similarity | Belongs to the mandelate racemase/muconate lactonizing enzyme family. RhamD subfamily. |
Keywords
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case <FTGroup:1>
end case
Gene Ontology
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case <FTGroup:1>
GO:0000287; Molecular function: magnesium ion binding.
end case
GO:0050032; Molecular function: L-rhamnonate dehydratase activity.
Cross-references
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Features
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From: RHMD_SALTY (Q8ZNF9) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 329 | 329 | Proton acceptor | H | ||||||||
BINDING | 226 | 226 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | D | 1 | |||||||
BINDING | 252 | 252 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | E | 1 | |||||||
BINDING | 280 | 280 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | E | 1 | |||||||
BINDING | 33 | 33 | /ligand="substrate | H | ||||||||
BINDING | 59 | 59 | /ligand="substrate | R | ||||||||
BINDING | 349 | 349 | /ligand="substrate | E | ||||||||
SITE | 302 | 302 | Increases basicity of active site His | D | ||||||||
SITE | 349 | 349 | Transition state stabilizer | E |
Additional information
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Size range | 390-428 amino acids |
Related rules | None |
Fusion | None |