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Annotation rule MF_01291 |
Accession | MF_01291 |
Dates | 3-OCT-2008 (Created) 19-NOV-2019 (Last updated, Version 14) |
Name | KDGluc_aldolase |
Scope | Bacteria; Gammaproteobacteria |
Template | P23522 (GARL_ECOLI) |
Triggered by |
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Protein name |
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Gene name |
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Function | Catalyzes the reversible retro-aldol cleavage of both 5-keto-4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdehyde. |
Catalytic activity | RHEA:27726: 5-dehydro-4-deoxy-D-glucarate = 2-hydroxy-3-oxopropanoate + pyruvate |
RHEA:10268: 2-dehydro-3-deoxy-D-glucarate = 2-hydroxy-3-oxopropanoate + pyruvate
EC 4.1.2.20 |
Cofactor | Mg(2+) Note: Binds 1 Mg(2+) ion per subunit. |
Pathway | Carbohydrate acid metabolism; galactarate degradation; D-glycerate from galactarate: step 2/3. |
Subunit | Homohexamer; trimer of dimers. |
Similarity | Belongs to the HpcH/HpaI aldolase family. KDGluc aldolase subfamily. |
From: GARL_ECOLI (P23522) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 50 | 50 | Proton acceptor | H | ||||||||
METAL | 153 | 153 | Magnesium | E | 1 | |||||||
METAL | 179 | 179 | Magnesium | D | 1 | |||||||
BINDING | 151 | 151 | Substrate | Q | ||||||||
BINDING | 178 | 178 | Substrate; via amide nitrogen | S | ||||||||
BINDING | 179 | 179 | Substrate | D | ||||||||
SITE | 75 | 75 | Transition state stabilizer | R | ||||||||
SITE | 89 | 89 | Increases basicity of active site His | D |
Size range | 250-282 amino acids |
Related rules | None |
Fusion | None |