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Annotation rule MF_01292 |
Accession | MF_01292 |
Dates | 3-OCT-2008 (Created) 19-NOV-2019 (Last updated, Version 11) |
Name | HKHD_aldolase |
Scope | Bacteria; Enterobacterales |
Template | Q47098 (HPCH_ECOLX) |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde. |
Catalytic activity | RHEA:25788: 4-hydroxy-2-oxoheptanedioate = pyruvate + succinate semialdehyde
EC 4.1.2.52 |
Cofactor | a divalent metal cation Note: Binds 1 divalent metal cation per subunit. |
Pathway | Aromatic compound metabolism; 4-hydroxyphenylacetate degradation; pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 7/7. |
Subunit | Homohexamer; trimer of dimers. |
Similarity | Belongs to the HpcH/HpaI aldolase family. |
From: HPCH_ECOLX (Q47098) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 45 | 45 | Proton acceptor | H | ||||||||
METAL | 149 | 149 | Divalent metal cation | E | ||||||||
METAL | 175 | 175 | Divalent metal cation | D | ||||||||
BINDING | 147 | 147 | Substrate | Q | ||||||||
BINDING | 174 | 174 | Substrate; via amide nitrogen | A | ||||||||
BINDING | 175 | 175 | Substrate | D | ||||||||
SITE | 70 | 70 | Transition state stabilizer | R | ||||||||
SITE | 84 | 84 | Increases basicity of active site His | D |
Size range | 262-267 amino acids |
Related rules | None |
Fusion | None |