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Annotation rule MF_01292
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General rule information [?]

Accession MF_01292
Dates 3-OCT-2008 (Created)
19-NOV-2019 (Last updated, Version 11)
Name HKHD_aldolase
Bacteria; Enterobacterales
Template Q47098 (HPCH_ECOLX)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=4-hydroxy-2-oxo-heptane-1,7-dioate aldolase;
AltName: Full=2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase;
Short=HHED aldolase;
AltName: Full=4-hydroxy-2-ketoheptane-1,7-dioate aldolase;
Short=HKHD aldolase;
Gene name
hpcH, hpaI

Comments [?]

Function Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.
Catalytic activity RHEA:25788: 4-hydroxy-2-oxoheptanedioate = pyruvate + succinate semialdehyde
Cofactor a divalent metal cation
Note: Binds 1 divalent metal cation per subunit.
Pathway Aromatic compound metabolism; 4-hydroxyphenylacetate degradation; pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 7/7.
Subunit Homohexamer; trimer of dimers.
Similarity Belongs to the HpcH/HpaI aldolase family.

Keywords [?]

Gene Ontology [?]

GO:0016832; Molecular function: aldehyde-lyase activity.
GO:0046872; Molecular function: metal ion binding.
GO:0019439; Biological process: aromatic compound catabolic process.

Cross-references [?]

Pfam PF03328; HpcH_HpaI; 1;
TIGRFAMs TIGR02311; HpaI; 1;

Features [?]

From: HPCH_ECOLX (Q47098)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     45     45       Proton acceptor     H  
METAL     149     149       Divalent metal cation     E  
METAL     175     175       Divalent metal cation     D  
BINDING     147     147       Substrate     Q  
BINDING     174     174       Substrate; via amide nitrogen     A  
BINDING     175     175       Substrate     D  
SITE     70     70       Transition state stabilizer     R  
SITE     84     84       Increases basicity of active site His     D  

Additional information [?]

Size range 262-267 amino acids
Related rules None
Fusion None