HAMAP logo

HAMAP rule MF_01292

Send feedback

General rule information [?]

Accession MF_01292
Dates 3-OCT-2008 (Created)
1-JUN-2023 (Last updated, Version 14)
Name HKHD_aldolase
Scope(s) Bacteria
Template(s) Q47098 (HPCH_ECOLX); [ Recover all ]
Triggered by HAMAP; MF_01292 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier HPCH
Protein name RecName: Full=4-hydroxy-2-oxo-heptane-1,7-dioate aldolase;
AltName: Full=2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase;
                 Short=HHED aldolase;
AltName: Full=4-hydroxy-2-ketoheptane-1,7-dioate aldolase;
                 Short=HKHD aldolase;
Gene name Name=hpcH; Synonyms=hpaI;

Comments [?]

FUNCTIONCatalyzes the reversible retro-aldol cleavage of 4-hydroxy-2- ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.
CATALYTIC ACTIVITY Reaction=4-hydroxy-2-oxoheptanedioate = pyruvate + succinate semialdehyde; Xref=Rhea:RHEA:25788, ChEBI:CHEBI:15361, ChEBI:CHEBI:57706, ChEBI:CHEBI:73036; EC=;
COFACTOR Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Note=Binds 1 divalent metal cation per subunit.;
PATHWAYAromatic compound metabolism; 4-hydroxyphenylacetate degradation; pyruvate and succinate semialdehyde from 4- hydroxyphenylacetate: step 7/7.
SUBUNITHomohexamer; trimer of dimers.
SIMILARITYBelongs to the HpcH/HpaI aldolase family.

Keywords [?]

Gene Ontology [?]

GO:0016832; Molecular function:aldehyde-lyase activity
GO:0046872; Molecular function:metal ion binding
GO:0019439; Biological process:aromatic compound catabolic process

Cross-references [?]

Pfam PF03328; HpcH_HpaI; 1;
NCBIfam TIGR02311; HpaI; 1;

Features [?]

From: HPCH_ECOLX (Q47098)
Key From To Description Tag Condition FTGroup
ACT_SITE 45 45 /note="Proton acceptor" H
BINDING 149 149 /ligand="a divalent metal cation"
BINDING 175 175 /ligand="a divalent metal cation"
BINDING 147 147 /ligand="substrate" Q
BINDING 174 174 /ligand="substrate" A
BINDING 175 175 /ligand="substrate" D
SITE 70 70 /note="Transition state stabilizer" R
SITE 84 84 /note="Increases basicity of active site His" D

Additional information [?]

Size range 262-267 amino acids
Related rules None
Fusion Nter: None Cter: None

View rule in raw text format (no links)