HAMAP rule MF_01299
General rule information
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| Accession | MF_01299 |
| Dates | 20-JAN-2009 (Created)
3-SEP-2024 (Last updated, Version 17) |
| Name | OadC |
| Scope(s) |
Bacteria Pseudomonadota |
| Template(s) | Q9HUU1 (OADC_PSEAE); [ Recover all ] |
| Triggered by |
HAMAP; MF_01299 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | OADC |
| Protein name | RecName: Full=Oxaloacetate decarboxylase; EC=4.1.1.112; |
Comments
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| FUNCTION | Catalyzes the decarboxylation of oxaloacetate into pyruvate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate. |
| CATALYTIC ACTIVITY | Reaction=oxaloacetate + H(+) = pyruvate + CO2; Xref=Rhea:RHEA:15641, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378, ChEBI:CHEBI:16452, ChEBI:CHEBI:16526; EC=4.1.1.112; |
| case <FT:1> | |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.; |
| end case | |
| SUBUNIT | Homotetramer; dimer of dimers. |
| SIMILARITY | Belongs to the isocitrate lyase family. Oxaloacetate decarboxylase subfamily. |
Keywords
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| Decarboxylase | |
| Lyase | |
| case <FT:1> | |
| Magnesium | |
| Metal-binding | |
| end case | |
Gene Ontology
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| case <FT:1> | |
| GO:0000287; Molecular function:magnesium ion binding | |
| end case | |
| GO:0008948; Molecular function:oxaloacetate decarboxylase activity | |
| GO:0006107; Biological process:oxaloacetate metabolic process | |
| GO:0042866; Biological process:pyruvate biosynthetic process | |
Cross-references
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Features
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| From: OADC_PSEAE (Q9HUU1) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 88 | 88 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | ||||||||
| BINDING | 50 | 50 | /ligand="substrate" | S | ||||||||
| BINDING | 159 | 159 | /ligand="substrate" | R | ||||||||
| BINDING | 235 | 235 | /ligand="substrate" | H | ||||||||
Additional information
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| Size range | 287-302 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |