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HAMAP rule MF_01308

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General rule information [?]

Accession MF_01308
Dates 29-NOV-2002 (Created)
17-OCT-2023 (Last updated, Version 38)
Name CemA_PxcA
Scope(s) Bacteria
Template(s) Q37050 (CEMA_CHLRE); [ Recover all ]
Triggered by
case c? <OC:Cyanobacteriota> or <OG:Chloroplast>
HAMAP; MF_01308 (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OG:Chloroplast>
Identifier CEMA
Protein name RecName: Full=Potassium/proton antiporter CemA;
AltName: Full=Chloroplast envelope membrane protein A;
Gene name Name=cemA;
else case <OC:Cyanobacteriota>
Identifier PXCA
Protein name RecName: Full=Proton extrusion protein PxcA;
Gene name Name=pxcA;
end case

Comments [?]

case <OG:Chloroplast>
FUNCTIONContributes to K(+)/H(+) antiport activity by supporting proton efflux to control proton extrusion and homeostasis in chloroplasts in a light-dependent manner to modulate photosynthesis. Prevents excessive induction of non-photochemical quenching (NPQ) under continuous-light conditions. Indirectly promotes efficient inorganic carbon uptake into chloroplasts.
CATALYTIC ACTIVITY Reaction=H(+)(out) + K(+)(in) = H(+)(in) + K(+)(out); Xref=Rhea:RHEA:29467, ChEBI:CHEBI:15378, ChEBI:CHEBI:29103;
SUBCELLULAR LOCATIONPlastid, chloroplast inner membrane; Multi-pass membrane protein.
else case <OC:Cyanobacteriota>
FUNCTIONRequired for H(+) efflux immediately after light irradiation to form a rapid H(+) concentration gradient across the thylakoid membranes. Together with PxcL, contributes to transient H(+) uptake following dark to light transition.
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein.
end case
SIMILARITYBelongs to the CemA family.

Keywords [?]

Gene Ontology [?]

GO:0015078; Molecular function:proton transmembrane transporter activity
GO:1902600; Biological process:proton transmembrane transport
case <OG:Chloroplast>
GO:0006813; Biological process:potassium ion transport
GO:0009706; Cellular component:chloroplast inner membrane
else case <OCellular component:Cyanobacteriota>
GO:0005886; Cellular component:plasma membrane
end case

Cross-references [?]

Pfam PF03040; CemA; 1;
General Transmembrane; -; 2-4;

Features [?]

Additional information [?]

Size range 226-501 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments The amino-terminus is very variable.

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