HAMAP rule MF_01308
General rule information
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| Accession | MF_01308 |
| Dates | 29-NOV-2002 (Created)
17-OCT-2023 (Last updated, Version 38) |
| Name | CemA_PxcA |
| Scope(s) |
Bacteria Cyanobacteriota Plastid |
| Template(s) | Q37050 (CEMA_CHLRE); [ Recover all ] |
| Triggered by |
case c? <OC:Cyanobacteriota> or <OG:Chloroplast>
HAMAP; MF_01308 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| case <OG:Chloroplast> | |
| Identifier | CEMA |
| Protein name | RecName: Full=Potassium/proton antiporter CemA; AltName: Full=Chloroplast envelope membrane protein A; Short=CemA; |
| Gene name | Name=cemA; |
| else case <OC:Cyanobacteriota> | |
| Identifier | PXCA |
| Protein name | RecName: Full=Proton extrusion protein PxcA; |
| Gene name | Name=pxcA; |
| end case | |
Comments
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| case <OG:Chloroplast> | |
| FUNCTION | Contributes to K(+)/H(+) antiport activity by supporting proton efflux to control proton extrusion and homeostasis in chloroplasts in a light-dependent manner to modulate photosynthesis. Prevents excessive induction of non-photochemical quenching (NPQ) under continuous-light conditions. Indirectly promotes efficient inorganic carbon uptake into chloroplasts. |
| CATALYTIC ACTIVITY | Reaction=H(+)(out) + K(+)(in) = H(+)(in) + K(+)(out); Xref=Rhea:RHEA:29467, ChEBI:CHEBI:15378, ChEBI:CHEBI:29103; |
| SUBCELLULAR LOCATION | Plastid, chloroplast inner membrane; Multi-pass membrane protein. |
| else case <OC:Cyanobacteriota> | |
| FUNCTION | Required for H(+) efflux immediately after light irradiation to form a rapid H(+) concentration gradient across the thylakoid membranes. Together with PxcL, contributes to transient H(+) uptake following dark to light transition. |
| SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
| end case | |
| SIMILARITY | Belongs to the CemA family. |
Keywords
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| Membrane | |
| Transmembrane | |
| case <OG:Chloroplast> | |
| Antiport | |
| Plastid inner membrane | |
| Potassium | |
| Potassium transport | |
| else case <OC:Cyanobacteriota> | |
| Cell membrane | |
| Cell inner membrane | |
| end case | |
| Transport | |
| Ion transport | |
| Hydrogen ion transport | |
| Transmembrane helix | |
Gene Ontology
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| GO:0015078; Molecular function:proton transmembrane transporter activity | |
| GO:1902600; Biological process:proton transmembrane transport | |
| case <OG:Chloroplast> | |
| GO:0006813; Biological process:potassium ion transport | |
| GO:0009706; Cellular component:chloroplast inner membrane | |
| else case <OCellular component:Cyanobacteriota> | |
| GO:0005886; Cellular component:plasma membrane | |
| end case | |
Cross-references
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| Pfam | PF03040; CemA; 1; |
| General | Transmembrane; -; 2-4; |
Features
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Additional information
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| Size range | 226-501 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | The amino-terminus is very variable. |