HAMAP rule MF_01312

General rule information [?]

Accession	MF_01312
Dates	20-MAR-2003 (Created) 19-NOV-2022 (Last updated, Version 38)

Name

NorV

Scope

Bacteria; Aeromonas

Bacteria; Aliivibrio

Bacteria; Citrobacter

Bacteria; Escherichia

Bacteria; Enterobacter

Bacteria; Klebsiella

Bacteria; Pectobacterium

Bacteria; Salmonella

Bacteria; Serratia

Bacteria; Shigella

Bacteria; Vibrio

Template

Q46877 (NORV_ECOLI)

Triggered by

HAMAP; MF_01312 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

NORV

Protein name

RecName:		Full=Anaerobic nitric oxide reductase flavorubredoxin;
		Short=FlRd;
		Short=FlavoRb;

Gene name

norV, flrD

Comments [?]

Function

Anaerobic nitric oxide reductase; uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center; electrons enter from the NorW at rubredoxin and are transferred sequentially to the FMN center and the di-iron center. Also able to function as an aerobic oxygen reductase.

case <FTGroup:1> and <FTGroup:2>

Cofactor

Fe cation
Note: Binds 3 Fe cations per monomer.

end case

case <Feature:PS50902>

Cofactor

FMN
Note: Binds 1 FMN per monomer.

end case

Pathway	Nitrogen metabolism; nitric oxide reduction.
Subunit	Homotetramer.
Subcellular location	Cytoplasm.

case <FT:1>

Similarity

In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

end case

Keywords [?]

Cytoplasm
Transport
Electron transport
Oxidoreductase

case <Feature:PS50902>

Flavoprotein
FMN

end case

case <FTGroup:1> or <FTGroup:2>

Metal-binding
Iron

end case

Gene Ontology [?]

GO:0009055; Molecular function: electron transfer activity.
GO:0016491; Molecular function: oxidoreductase activity.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF00258; Flavodoxin_1; 1;
	PF00753; Lactamase_B; 1;
	PF00301; Rubredoxin; 1;
	PF00070; Pyr_redox; 1;
PIRSF	PIRSF005243; ROO; 1;
PRINTS	PR00163; RUBREDOXIN; 1;
PROSITE	PS50902; FLAVODOXIN_LIKE; 1; trigger=PRU00088;
	PS50903; RUBREDOXIN_LIKE; 1;

Features [?]

From: NORV_ECOLI (Q46877)

Key From To Description Tag Condition FTGroup

DOMAIN 423 474 Rubredoxin-like

REGION 30 210 Zinc metallo-hydrolase

BINDING 79 79 /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1 H 1

BINDING 81 81 /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1 E 1

BINDING 83 83 /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2 D 1

BINDING 147 147 /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1 H 1

BINDING 166 166 /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1 D 1

BINDING 166 166 /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2 D 1

BINDING 227 227 /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2 H 1

BINDING 428 428 /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="3 C 2

BINDING 431 431 /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="3 C 2

BINDING 461 461 /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="3 C 2

BINDING 464 464 /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="3 C 2

Additional information [?]

Size range	479-521 amino acids
Related rules	None
Fusion	None
Comments	ECO57 lacks the flavodoxin-like domain and is not used in alignment. Restricted to lineages where there is norR upstream and norW downstream.

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