HAMAP rule MF_01318
General rule information
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| Accession | MF_01318 |
| Dates | 22-JUL-2003 (Created)
22-SEP-2023 (Last updated, Version 35) |
| Name | Ribosomal_uL1 |
| Scope(s) |
Bacteria Archaea Plastid |
| Template(s) | P0A7L0 (RL1_ECOLI); Q5SLP7 (RL1_THET8); P27150 (RL1_THETH); P54050 (RL1_METJA); O52704 (RL1_METTL); P35024 (RL1_SULAC); [ Recover all ] |
| Triggered by |
case c? <OC:Bacteria> or <OG:Chloroplast>
HAMAP; MF_01318_B (Get profile general information and statistics) end case
case c? <OC:Archaea>
HAMAP; MF_01318_A (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| case <OC:Bacteria> and not <OC:Cyanobacteriota> | |
| Identifier | RL1 |
| Protein name | RecName: Full=Large ribosomal subunit protein uL1; |
| Gene name | Name=rplA; |
| else case <OC:Cyanobacteriota> | |
| Identifier | RL1 |
| Protein name | RecName: Full=Large ribosomal subunit protein uL1; |
| Gene name | Name=rplA; Synonyms=rpl1; |
| else case <OC:Archaea> | |
| Identifier | RL1 |
| Protein name | RecName: Full=Large ribosomal subunit protein uL1; |
| Gene name | Name=rpl1; |
| else case <OG:Chloroplast> | |
| Identifier | RK1 |
| Protein name | RecName: Full=Large ribosomal subunit protein uL1c; |
| Gene name | Name=rpl1; |
| end case | |
Comments
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| case <OC:Bacteria> | |
| FUNCTION | Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. |
| FUNCTION | Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA. |
| else case <OC:Archaea> | |
| FUNCTION | Binds directly to 23S rRNA. Probably involved in E site tRNA release. |
| FUNCTION | Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA. |
| end case | |
| SUBUNIT | Part of the 50S ribosomal subunit. |
| case <OG:Chloroplast> | |
| FUNCTION | Binds directly to 23S rRNA. Might be involved in E site tRNA release. |
| SUBCELLULAR LOCATION | Plastid, chloroplast. |
| end case | |
| SIMILARITY | Belongs to the universal ribosomal protein uL1 family. |
Keywords
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| Ribonucleoprotein | |
| Ribosomal protein | |
| RNA-binding | |
| rRNA-binding | |
| case not <OG:Chloroplast> | |
| Repressor | |
| Translation regulation | |
| tRNA-binding | |
| end case | |
Gene Ontology
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| GO:0019843; Molecular function:rRNA binding | |
| GO:0006412; Biological process:translation | |
| case <OG:Chloroplast> | |
| GO:0009507; Cellular component:chloroplast | |
| end case | |
Cross-references
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Features
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Additional information
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| Size range | 209-253 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: <Unknown> |
| Comments | C-terminal fusion in MALP2, quite atypical in NEOSM. Some of the Rickettsiales are about 15 residues shorter at the N-terminus. L1 proteins from thermophilic organisms have an approximately 10-fold higher affinity for their binding sites on both 23S rRNA and mRNA than do their mesophilic counterparts, maybe helping to explain the ribosome's greater stability in thermophiles. See: PubMed=9746351; Kohrer C., Mayer C., Neumair O., Grobner P., Piendl W.; "Interaction of ribosomal L1 proteins from mesophilic and thermophilic Archaea and Bacteria with specific L1-binding sites on 23S rRNA and mRNA."; Eur. J. Biochem. 256:97-105(1998). |