HAMAP rule MF_01319

General rule information [?]

Accession	MF_01319
Dates	27-AUG-2003 (Created) 15-FEB-2022 (Last updated, Version 30)

Name

ResA

Scope

Bacteria; Bacillaceae

Template

P35160 (RESA_BACSU)

Triggered by

HAMAP; MF_01319 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

RESA

Protein name

RecName:

Full=Thiol-disulfide oxidoreductase ResA;

Gene name

resA

Comments [?]

Function	Thiol-disulfide oxidoreductase which is required in disulfide reduction during c-type cytochrome synthesis. May accept reducing equivalents from CcdA, leading to breakage of disulfide bonds in apocytochrome c; following this reduction heme can be covalently attached.
Pathway	Protein modification; cytochrome c assembly.
Subcellular location	Cell membrane; Single-pass type II membrane protein. Note=The thioredoxin-like motif is exposed on the outside of the membrane.
Similarity	Belongs to the thioredoxin family. ResA subfamily.

Keywords [?]

Cell membrane
Cytochrome c-type biogenesis

case <FT:2>

Disulfide bond

end case

Membrane
Oxidoreductase
Redox-active center
Signal-anchor
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0015036; Molecular function: disulfide oxidoreductase activity.
GO:0017004; Biological process: cytochrome complex assembly.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam	PF00578; AhpC-TSA; 1;
PROSITE	PS00194; THIOREDOXIN_1; 1;
	PS51352; THIOREDOXIN_2; 1; trigger=PRU00691;

Features [?]

From: RESA_BACSU (P35160)

Key From To Description Tag Condition FTGroup

TRANSMEM 11 30 Helical; Signal-anchor for type II membrane protein

DISULFID 74 77 Redox-active C-x-P-C

Additional information [?]

Size range	173-192 amino acids
Related rules	None
Fusion	None

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