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Annotation rule MF_01319
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General rule information [?]

Accession MF_01319
Dates 27-AUG-2003 (Created)
19-NOV-2019 (Last updated, Version 29)
Name ResA
Scope
Bacteria; Bacillaceae
Template P35160 (RESA_BACSU)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
RESA
Protein name
RecName: Full=Thiol-disulfide oxidoreductase ResA;
Gene name
resA

Comments [?]

Function Thiol-disulfide oxidoreductase which is required in disulfide reduction during c-type cytochrome synthesis. May accept reducing equivalents from CcdA, leading to breakage of disulfide bonds in apocytochrome c; following this reduction heme can be covalently attached.
Pathway Protein modification; cytochrome c assembly.
Subcellular location Cell membrane; Single-pass type II membrane protein. Note=The thioredoxin-like motif is exposed on the outside of the membrane.
Similarity Belongs to the thioredoxin family. ResA subfamily.

Keywords [?]

Cell membrane
Cytochrome c-type biogenesis
case <FT:2>
Disulfide bond
end case
Membrane
Oxidoreductase
Redox-active center
Signal-anchor
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0015036; Molecular function: disulfide oxidoreductase activity.
GO:0017004; Biological process: cytochrome complex assembly.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF00578; AhpC-TSA; 1;
PROSITE PS00194; THIOREDOXIN_1; 1;
PS51352; THIOREDOXIN_2; 1; trigger=PRU00691;

Features [?]

From: RESA_BACSU (P35160)
Key     From     To       Description   Tag   Condition   FTGroup
TRANSMEM     11     30       Helical; Signal-anchor for type II membrane protein        
DISULFID     74     77       Redox-active     C-x-P-C  

Additional information [?]

Size range 173-192 amino acids
Related rules None
Fusion None


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