HAMAP rule MF_01351

General rule information [?]

Accession	MF_01351
Dates	23-JUN-2006 (Created) 28-JUN-2024 (Last updated, Version 51)
Name	NDH1_NuoI
Scope(s)	Bacteria Plastid
Template(s)	Q56224 (NQO9_THET8); P0AFD6 (NUOI_ECOLI); [ Recover all ]
Triggered by	HAMAP; MF_01351 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OG:Chloroplast>
Identifier	NDHI
Protein name	RecName: Full=NAD(P)H-quinone oxidoreductase subunit I, chloroplastic; EC=7.1.1.-; AltName: Full=NAD(P)H dehydrogenase subunit I; Short=NDH subunit I; AltName: Full=NADH-plastoquinone oxidoreductase subunit I;
Gene name	Name=ndhI;
else case <OC:Cyanobacteriota>
Identifier	NDHI
Protein name	RecName: Full=NAD(P)H-quinone oxidoreductase subunit I; EC=7.1.1.-; AltName: Full=NAD(P)H dehydrogenase I subunit I; AltName: Full=NDH-1 subunit I; Short=NDH-I;
Gene name	Name=ndhI;
else
Identifier	NUOI
Protein name	RecName: Full=NADH-quinone oxidoreductase subunit I; EC=7.1.1.-; AltName: Full=NADH dehydrogenase I subunit I; AltName: Full=NDH-1 subunit I;
Gene name	Name=nuoI;
end case

Comments [?]

case <OG:Chloroplast>
FUNCTION	NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
else case <OC:Cyanobacteriota>
FUNCTION	NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
else case <OC:Mycobacterium> or <OC:Rhodothermus>
FUNCTION	NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
else
FUNCTION	NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
end case
case <OG:Chloroplast> or <OC:Cyanobacteriota>
CATALYTIC ACTIVITY	Reaction=a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n H(+)(out) + NAD(+); Xref=Rhea:RHEA:42608, Rhea:RHEA-COMP:9561, Rhea:RHEA-COMP:9562, ChEBI:CHEBI:15378, ChEBI:CHEBI:17757, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:62192;
CATALYTIC ACTIVITY	Reaction=a plastoquinone + (n+1) H(+)(in) + NADPH = a plastoquinol + n H(+)(out) + NADP(+); Xref=Rhea:RHEA:42612, Rhea:RHEA-COMP:9561, Rhea:RHEA-COMP:9562, ChEBI:CHEBI:15378, ChEBI:CHEBI:17757, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:62192;
else
CATALYTIC ACTIVITY	Reaction=a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+); Xref=Rhea:RHEA:57888, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:132124;
end case
COFACTOR	Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 2 [4Fe-4S] clusters per subunit.;
case <OG:Chloroplast>
SUBUNIT	NDH is composed of at least 16 different subunits, 5 of which are encoded in the nucleus.
else case <OC:Cyanobacteriota>
SUBUNIT	NDH-1 is composed of at least 11 different subunits.
else case <OC:Enterobacterales> or <OC:Shewanellaceae> or <OC:Pseudomonadaceae>
SUBUNIT	NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
else case <OC:Deinococci>
SUBUNIT	NDH-1 is composed of 15 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
else
SUBUNIT	NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
end case
case <OG:Chloroplast>
SUBCELLULAR LOCATION	Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
else case <OC:Cyanobacteriota> and not <OC:Gloeobacter>
SUBCELLULAR LOCATION	Cellular thylakoid membrane; Peripheral membrane protein.
else case <OC:Gloeobacter>
SUBCELLULAR LOCATION	Cell inner membrane; Peripheral membrane protein.
else case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATION	Cell membrane; Peripheral membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATION	Cell inner membrane; Peripheral membrane protein.
end case
SIMILARITY	Belongs to the complex I 23 kDa subunit family.

Keywords [?]

NAD
Quinone
4Fe-4S
Iron
Iron-sulfur
Metal-binding
Membrane
case <OG:Chloroplast> or <OC:Cyanobacteriota> and not <OC:Gloeobacter>
Thylakoid
else case <OC:Gloeobacter>
Cell membrane
Cell inner membrane
else case not defined <Property:Membrane> or <Property:Membrane=1>
Cell membrane
else case <Property:Membrane=2>
Cell membrane
Cell inner membrane
end case
case <OG:Chloroplast> or <OC:Cyanobacteriota>
Plastoquinone
NADP
else case not <OC:Mycobacterium> and not <OC:Rhodothermus> and not <OC:Archaea>
Ubiquinone
end case
<a href="https://www.uniprot.org/keywords/KW-1278">Translocase</a>

Gene Ontology [?]

GO:0005506; Molecular function:iron ion binding
case <OG:Chloroplast> or <OCellular component:Cyanobacteriota>
GO:0016655; Molecular function:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0019684; Biological process:photosynthesis, light reaction
else; https://www.ebi.ac.uk/QuickGO/term/else
GO:0050136; Molecular function:NADH:ubiquinone reductase (non-electrogenic) activity
end case
case <OCellular component:Cyanobacteriota> and not <OC:Gloeobacter>
GO:0042651; Cellular component:thylakoid membrane
else case <OG:Chloroplast>
GO:0009535; Cellular component:chloroplast thylakoid membrane
else; https://www.ebi.ac.uk/QuickGO/term/else
GO:0005886; Cellular component:plasma membrane
end case

Cross-references [?]

Pfam	PF00037; Fer4; 2;
PRINTS	PR00353; 4FE4SFRDOXIN; 1;
PROSITE	PS00198; 4FE4S_FER_1; 2;
PROSITE	PS51379; 4FE4S_FER_2; 2;
NCBIfam	TIGR00403; ndhI; 0-1;
NCBIfam	TIGR01971; NuoI; 1;

Features [?]

From: NQO9_THET8 (Q56224)
Key	From	To	Description	Tag	Condition	FTGroup
BINDING	53	53	/ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="1"		C	1
BINDING	56	56	/ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="1"		C	1
BINDING	59	59	/ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="1"		C	1
BINDING	63	63	/ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="2"		C	2
BINDING	98	98	/ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="2"		C	2
BINDING	101	101	/ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="2"		C	2
BINDING	104	104	/ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="2"		C	2
BINDING	108	108	/ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="1"		C	1

Additional information [?]

Size range	131-264 amino acids
Related rules	None
Fusion	Nter: MF_01350 (nuoH) Cter: None
Comments	In NOCFA is N-terminally fused with nuoH, another subunit of the same complex. See also comments on subunit composition in family MF_01350 (nuoH/ndhA). THET8 and PARDE are annotated with another nomenclature.

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