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HAMAP rule MF_01355

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General rule information [?]

Accession MF_01355
Dates 8-SEP-2008 (Created)
15-JUN-2023 (Last updated, Version 17)
Scope(s) Bacteria
Template(s) P27372 (NDHL_SYNY3); [ Recover all ]
Triggered by HAMAP; MF_01355 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier NDHL
Protein name RecName: Full=NAD(P)H-quinone oxidoreductase subunit L;
AltName: Full=NAD(P)H dehydrogenase I subunit L;
                 Short=NDH-1 subunit L;
Gene name Name=ndhL;

Comments [?]

FUNCTIONNDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
CATALYTIC ACTIVITY Reaction=a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n H(+)(out) + NAD(+); Xref=Rhea:RHEA:42608, Rhea:RHEA-COMP:9561, Rhea:RHEA-COMP:9562, ChEBI:CHEBI:15378, ChEBI:CHEBI:17757, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:62192;
CATALYTIC ACTIVITY Reaction=a plastoquinone + (n+1) H(+)(in) + NADPH = a plastoquinol + n H(+)(out) + NADP(+); Xref=Rhea:RHEA:42612, Rhea:RHEA-COMP:9561, Rhea:RHEA-COMP:9562, ChEBI:CHEBI:15378, ChEBI:CHEBI:17757, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:62192;
SUBUNITNDH-1 can be composed of about 15 different subunits; different subcomplexes with different compositions have been identified which probably have different functions.
SUBCELLULAR LOCATIONCellular thylakoid membrane; Multi-pass membrane protein.
SIMILARITYBelongs to the complex I NdhL subunit family.

Keywords [?]

Transmembrane helix
<a href="https://www.uniprot.org/keywords/KW-1278">Translocase</a>

Gene Ontology [?]

GO:0016655; Molecular function:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0042651; Cellular component:thylakoid membrane

Cross-references [?]

General Transmembrane; -; 2;

Features [?]

Additional information [?]

Size range 69-89 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments One of a number of subunits unique to cyanobacteria and plastids, it is nuclearly encoded in angiosperms.

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