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HAMAP rule MF_01381

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General rule information [?]

Accession MF_01381
Dates 12-NOV-2007 (Created)
19-NOV-2019 (Last updated, Version 17)
Name EmtA
Scope(s) Bacteria
Template(s) P0C960 (EMTA_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01381 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier EMTA
Protein name RecName: Full=Endo-type membrane-bound lytic murein transglycosylase A;
AltName: Full=Peptidoglycan lytic endotransglycosylase;
                 Flags: Precursor;
Gene name Name=emtA;

Comments [?]

FUNCTIONMurein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Preferentially cleaves at a distance of more than two disaccharide units from the ends of the glycan chain.
CATALYTIC ACTIVITY Reaction=Endolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.; EC=4.2.2.n2;
SUBCELLULAR LOCATIONCell outer membrane; Lipid-anchor.
SIMILARITYBelongs to the transglycosylase Slt family.

Keywords [?]

Gene Ontology [?]

GO:0016837; Molecular function:carbon-oxygen lyase activity, acting on polysaccharides
GO:0016998; Biological process:cell wall macromolecule catabolic process
GO:0009279; Cellular component:cell outer membrane

Cross-references [?]

Pfam PF01464; SLT; 1;

Features [?]

Additional information [?]

Size range 203-219 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Due to a small duplication there is a second copy in SHIFL 301 / Serotype 2a that does not have a lipobox and is annotated as atypical.

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