HAMAP rule MF_01381
General rule information
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| Accession | MF_01381 |
| Dates | 12-NOV-2007 (Created)
19-NOV-2019 (Last updated, Version 17) |
| Name | EmtA |
| Scope(s) |
Bacteria Enterobacterales |
| Template(s) | P0C960 (EMTA_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01381 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | EMTA |
| Protein name | RecName: Full=Endo-type membrane-bound lytic murein transglycosylase A; EC=4.2.2.n2; AltName: Full=Peptidoglycan lytic endotransglycosylase; Flags: Precursor; |
| Gene name | Name=emtA; |
Comments
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| FUNCTION | Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Preferentially cleaves at a distance of more than two disaccharide units from the ends of the glycan chain. |
| CATALYTIC ACTIVITY | Reaction=Endolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.; EC=4.2.2.n2; |
| SUBCELLULAR LOCATION | Cell outer membrane; Lipid-anchor. |
| SIMILARITY | Belongs to the transglycosylase Slt family. |
Keywords
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| Cell wall biogenesis/degradation | |
| Lyase | |
| Membrane | |
| Cell outer membrane | |
| Signal | |
| case <Feature:PS51257> | |
| Lipoprotein | |
| Palmitate | |
| end case | |
Gene Ontology
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| GO:0016837; Molecular function:carbon-oxygen lyase activity, acting on polysaccharides |
| GO:0016998; Biological process:cell wall macromolecule catabolic process |
| GO:0009279; Cellular component:cell outer membrane |
Cross-references
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Features
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Additional information
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| Size range | 203-219 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Due to a small duplication there is a second copy in SHIFL 301 / Serotype 2a that does not have a lipobox and is annotated as atypical. |