HAMAP rule MF_01381

General rule information [?]

Accession	MF_01381
Dates	12-NOV-2007 (Created) 19-NOV-2019 (Last updated, Version 17)

Name

EmtA

Scope

Bacteria; Enterobacterales

Template

P0C960 (EMTA_ECOLI)

Triggered by

HAMAP; MF_01381 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

EMTA

Protein name

RecName:		Full=Endo-type membrane-bound lytic murein transglycosylase A;
		EC 4.2.2.n2;
AltName:		Full=Peptidoglycan lytic endotransglycosylase;
Flags:		Precursor;

Gene name

emtA

Comments [?]

Function	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Preferentially cleaves at a distance of more than two disaccharide units from the ends of the glycan chain.
Catalytic activity	Reaction=Endolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.; EC=4.2.2.n2;
Subcellular location	Cell outer membrane; Lipid-anchor.
Similarity	Belongs to the transglycosylase Slt family.

Keywords [?]

Cell wall biogenesis/degradation
Lyase
Membrane
Cell outer membrane
Signal

case <Feature:PS51257>

Lipoprotein
Palmitate

end case

Gene Ontology [?]

GO:0016837; Molecular function: carbon-oxygen lyase activity, acting on polysaccharides.
GO:0016998; Biological process: cell wall macromolecule catabolic process.
GO:0009279; Cellular component: cell outer membrane.

Cross-references [?]

PROSITE	PS51257; PROKAR_LIPOPROTEIN; 1; trigger=PRU00303;
	PS00922; TRANSGLYCOSYLASE; 1;
Pfam	PF01464; SLT; 1;

Additional information [?]

Size range	203-219 amino acids
Related rules	None
Fusion	None
Comments	Due to a small duplication there is a second copy in SHIFL 301 / Serotype 2a that does not have a lipobox and is annotated as atypical.

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