HAMAP rule MF_01381
General rule information
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Accession | MF_01381 |
Dates | 12-NOV-2007 (Created)
19-NOV-2019 (Last updated, Version 17) |
Name | EmtA |
Scope(s) |
Bacteria Enterobacterales |
Template(s) | P0C960 (EMTA_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_01381 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | EMTA |
Protein name | RecName: Full=Endo-type membrane-bound lytic murein transglycosylase A; EC=4.2.2.n2; AltName: Full=Peptidoglycan lytic endotransglycosylase; Flags: Precursor; |
Gene name | Name=emtA; |
Comments
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FUNCTION | Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Preferentially cleaves at a distance of more than two disaccharide units from the ends of the glycan chain. |
CATALYTIC ACTIVITY | Reaction=Endolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.; EC=4.2.2.n2; |
SUBCELLULAR LOCATION | Cell outer membrane; Lipid-anchor. |
SIMILARITY | Belongs to the transglycosylase Slt family. |
Keywords
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Cell wall biogenesis/degradation | |
Lyase | |
Membrane | |
Cell outer membrane | |
Signal | |
case <Feature:PS51257> | |
Lipoprotein | |
Palmitate | |
end case |
Gene Ontology
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GO:0016837; Molecular function:carbon-oxygen lyase activity, acting on polysaccharides |
GO:0016998; Biological process:cell wall macromolecule catabolic process |
GO:0009279; Cellular component:cell outer membrane |
Cross-references
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Features
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Additional information
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Size range | 203-219 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |
Comments | Due to a small duplication there is a second copy in SHIFL 301 / Serotype 2a that does not have a lipobox and is annotated as atypical. |