HAMAP rule MF_01381

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_01381
Accession	MF_01381
Dates	12-NOV-2007 (Created) 19-NOV-2019 (Last updated, Version 18)
Name	EmtA
Scope(s)	Bacteria Enterobacterales
Template(s)	P0C960; [ Recover all ]
Triggered by	HAMAP; MF_01381 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	EMTA
Protein name	RecName: Full=Endo-type membrane-bound lytic murein transglycosylase A; EC=4.2.2.n2; AltName: Full=Peptidoglycan lytic endotransglycosylase; Flags: Precursor;
Gene name	Name=emtA;

Comments [?]

FUNCTION	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Preferentially cleaves at a distance of more than two disaccharide units from the ends of the glycan chain.
CATALYTIC ACTIVITY	Reaction=Endolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.; EC=4.2.2.n2;
SUBCELLULAR LOCATION	Cell outer membrane; Lipid-anchor.
SIMILARITY	Belongs to the transglycosylase Slt family.

Keywords [?]

Cell wall biogenesis/degradation
Lyase
Membrane
Cell outer membrane
Signal
case <Feature:PS51257>
Lipoprotein
Palmitate
end case

Gene Ontology [?]

GO:0016837; Molecular function:carbon-oxygen lyase activity, acting on polysaccharides

GO:0016998; Biological process:cell wall macromolecule catabolic process

GO:0009279; Cellular component:cell outer membrane

Cross-references [?]

Features [?]

Additional information [?]

Size range	203-219 amino acids
Related rules	None
Fusion	Nter: None Cter: None
Comments	Due to a small duplication there is a second copy in SHIFL 301 / Serotype 2a that does not have a lipobox and is annotated as atypical.