HAMAP rule MF_01395
General rule information
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Accession | MF_01395 |
Dates | 27-NOV-2008 (Created)
1-JUN-2023 (Last updated, Version 24) |
Name | AcetylCoA_CT_beta |
Scope(s) |
Bacteria Plastid |
Template(s) | P0A9Q5 (ACCD_ECOLI); Q5HF73 (ACCD_STAAC); Q2MI91 (ACCD_SOLLC); P18823 (ACCD_PEA); [ Recover all ] |
Triggered by |
HAMAP; MF_01395 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | ACCD |
case <OG:Chloroplast> | |
Protein name | RecName: Full=Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic; Short=ACCase subunit beta; Short=Acetyl-CoA carboxylase carboxyltransferase subunit beta; EC=2.1.3.15; |
Gene name | Name=accD; |
else | |
Protein name | RecName: Full=Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta; Short=ACCase subunit beta; Short=Acetyl-CoA carboxylase carboxyltransferase subunit beta; EC=2.1.3.15; |
Gene name | Name=accD; |
end case |
Comments
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FUNCTION | Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. |
CATALYTIC ACTIVITY | Reaction=acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl- CoA + N(6)-biotinyl-L-lysyl-[protein]; Xref=Rhea:RHEA:54728, Rhea:RHEA-COMP:10505, Rhea:RHEA-COMP:10506, ChEBI:CHEBI:57288, ChEBI:CHEBI:57384, ChEBI:CHEBI:83144, ChEBI:CHEBI:83145; EC=2.1.3.15; |
case <FTGroup:1> | |
COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.; |
end case | |
PATHWAY | Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. |
case <OG:Chloroplast> | |
SUBUNIT | Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein, biotin carboxylase and two subunits each of ACCase subunit alpha and ACCase plastid-coded subunit beta (accD). |
else | |
SUBUNIT | Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). |
end case | |
case <OC:Bacteria> | |
SUBCELLULAR LOCATION | Cytoplasm. |
else case <OG:Chloroplast> | |
SUBCELLULAR LOCATION | Plastid, chloroplast stroma. |
end case | |
SIMILARITY | Belongs to the AccD/PCCB family. |
Keywords
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ATP-binding | |
Fatty acid biosynthesis | |
Fatty acid metabolism | |
Lipid biosynthesis | |
Lipid metabolism | |
Nucleotide-binding | |
Transferase | |
case <FTGroup:1> | |
Metal-binding | |
Zinc | |
Zinc-finger | |
end case | |
case <OC:Bacteria> | |
Cytoplasm | |
end case |
Gene Ontology
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GO:0016743; Molecular function:carboxyl- or carbamoyltransferase activity | |
GO:0006633; Biological process:fatty acid biosynthetic process | |
case <OCellular component:Bacteria> | |
GO:0005737; Cellular component:cytoplasm | |
else case <OG:Chloroplast> | |
GO:0009570; Cellular component:chloroplast stroma | |
end case | |
case <FTGroup:1> | |
GO:0008270; Molecular function:zinc ion binding | |
end case |
Cross-references
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PROSITE | PS50980; COA_CT_NTER; 1; |
Pfam | PF01039; Carboxyl_trans; 1; |
PRINTS | PR01070; ACCCTRFRASEB; 1; |
NCBIfam | TIGR00515; AccD; 1; |
Features
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From: ACCD_ECOLI (P0A9Q5) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
case not <OC:Mycobacterium> | ||||||||||||
ZN_FING | 27 | 49 | /note="C4-type" | C-x(1,2)-C-x(12,18)-C-x(1,2)-C | ||||||||
BINDING | 27 | 27 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
BINDING | 30 | 30 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
BINDING | 46 | 46 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
BINDING | 49 | 49 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
end case |
Additional information
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Size range | 288-700 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: MF_00823 (accA) |
Comments | A few Bacillota encode a fusion between AccD and AccA (CLOTE, EUBR3, FRAAA, FRACC, FRASN, NATTJ) as do a few Actinomycetota (SACEN, SALAI and SALTO). Most plants have 2 forms, the so-called prokaryotic form in their plastids and the eukaryotic form in the cytoplasm. The prokaryotic form is longer than the one found in bacteria. The grass family (Poaceae) have only the eukaryotic form in both locations and an occasional fragment of the other form which may or may not be expressed (see rice). The eukaryotic form consists of a single large protein in which are fused all 4 subunits that are separate in prokaryotes. Not all proteins are able to bind the zinc. Mycobacteria do not seem to have this particular protein; they have 6 accD paralogues however. |